US4906378A
Expired / Lapsed
US
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Composite chromatographic article
Assignee: 3M Co
•
Filing: 1988-11-22
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Granted: 1990-03-06
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Expires: 2008-11-22
Abstract
Abstract A composite chromatographic article comprising: (a) a polytetrafluoroethylene fibril matrix, and (b) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable sorptive particles to polytetrafluoroethylene being in the range of 19:1 to 4:1 by weight, said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter.
Inventors
- 👤 Donald F. Hagen
- 👤 Steven J. St. Mary
- 👤 Louise A. Errede
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 00:47
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/28; B01J20/28014; B01J20/28028; B01J20/28033
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
116 words
A method of chromatographic separation comprising the steps of: (a) spotting a solution containing separable components in a circular configuration onto a rotatable chromatographic sheet-like article wherein said chromatographic sheet-like article is a composite article comprising: (1) a polytetra fluoroethylene fibril matrix, and (2) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable particles to PTFE being in the range of 19:1 to 4:1 by weight, said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter, (b) wicking solvent onto said chromatographic sheet-like article, just inside said spotted circular configuration, while said article is continuously rotating, to effect differential migration of said components and their separation.
Claim 2
Independent Claim
116 words
A method of chromatographic separation comprising the steps of: (a) spotting a solution containing separable components in a circular configuration onto a rotatable chromatographic sheet-like article wherein said chromatographic sheet-like article is a composite article comprising: (1) a polytetra fluoroethylene fibril matrix, and (2) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable particles to PTFE being in the range of 19:1 to 4:1 by weight, said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter, (b) wicking solvent onto said chromatographic sheet-like article, just inside said spotted circular configuration, while said article is continuously rotating, to effect differential migration of said components and their separation.
Claim 3
Dependent Claim
17 words
The method according to claim 1 further comprising the step of individually collecting said resulting separated components.
Claim 4
Dependent Claim
32 words
The method according to claim 1 wherein said matrix further comprises in the range of more than zero and up to 28.99 parts per part of PTFE of non-swellable property modifying particles.
Claim 5
Dependent Claim
41 words
The method according to claim 3 wherein said consisting of calcium carbonate, ammonium carbonate, kaolin, sugar, polyethylenes, polypropylenes, polyesters, polyamides, polyurethanes, polycarbonates, zeolites, chitosan, glass beads, vermiculite, clay, ceramics, coloring or fluorescing particles, pH modifiers, and particles coated with these substances.
Claim 6
Dependent Claim
24 words
The method according to claim 1 further comprising water-swellable property modifying particles in an amount up to 30 weight percent of the total particles.
Claim 7
Dependent Claim
35 words
The method according to claim 5 wherein said water-swellable property modifying particles are selected from the group consisting of starch, modified starch, agarose, polyacrylamides, ion exchange and chelating particles, cellulosics, polymethacrylates, styrene-divinylbenzene copolymers, and chitosan.
Claim 8
Dependent Claim
13 words
The method according to claim 1 wherein said non-swellable particles are inorganic oxide.
Claim 9
Dependent Claim
14 words
The method according to claim 1 wherein said non-swellable particles are an organic compound.
Claim 10
Dependent Claim
13 words
The method according to claim 1 wherein said non-swellable particles are a polymer.
Claim 11
Dependent Claim
18 words
The method according to claim 1 wherein said non-swellable particles are at least one of silica and zirconia.
Claim 12
Dependent Claim
12 words
The method according to claim 1 wherein said non-swellable particles are silica.
Claim 13
Dependent Claim
16 words
The method according to claim 1 wherein said non-swellable particles are chelating or ion exchange particles.
Claim 14
Dependent Claim
18 words
The method according to claim 1 wherein said particles further comprise a layer of covalently bonded organic coating.
Claim 15
Dependent Claim
16 words
The method according to claim 1 wherein said particles further comprise a coating of non-swellable polymer.
Claim 16
Dependent Claim
17 words
The method according to claim 1 wherein said chromatographic article has been subjected to electron beam treatment.
Claim 17
Dependent Claim
12 words
The method according to claim 1 wherein said non-swellable particles are hydroxylapatite.
Claim 18
Independent Claim
122 words
A method of chromatographic separation comprising the steps of: (a) depositing a solution containing separable components in a circular configuration onto a rotatable chromatographic sheet-like article to provide a circular zone of deposited solution, wherein said chromatographic sheet-like article is a composite article comprising: (1) a polytetrafluoroethylene fibril matrix, and (2) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable particles to PTFE being in the range of 19:1 to 4:1 by weight, said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter, (b) wicking solvent onto said chromatographic sheet-like article, just inside said circular zone, while said article is continuously rotating, to effect differential migration of said components and their separation.
Claim 19
Independent Claim
122 words
A method of chromatographic separation comprising the steps of: (a) depositing a solution containing separable components in a circular configuration onto a rotatable chromatographic sheet-like article to provide a circular zone of deposited solution, wherein said chromatographic sheet-like article is a composite article comprising: (1) a polytetrafluoroethylene fibril matrix, and (2) non-swellable sorptive particles enmeshed in said matrix, the ratio of non-swellable particles to PTFE being in the range of 19:1 to 4:1 by weight, said composite article having a net surface energy in the range of 20 to 300 milliNewtons per meter, (b) wicking solvent onto said chromatographic sheet-like article, just inside said circular zone, while said article is continuously rotating, to effect differential migration of said components and their separation.
Claim 20
Dependent Claim
17 words
The method according to claim 17 further comprising the step of individually collecting said resulting separated components.
Claim 21
Dependent Claim
33 words
The method according to claim 17 wherein said matrix further comprises in the range of more than zero and up to b 28.99 parts per part of PTFE of non-swellable property modifying particles.
Claim 22
Dependent Claim
49 words
The method according to claim 19, wherein said property modifying particles are selected from the group consisting of calcium carbonate, ammonium carbonate, kaolin, sugar, polyethylenes, polypropylenes, polyesters, polyamides, polyurethanes, polycarbonates, zeolites, chitosan, glass beads, vermiculite, clay, ceramics, coloring or fluorescing particles, pH modifiers, and particles coated with these substances.
Claim 23
Dependent Claim
24 words
The method according to claim 17 further comprising water-swellable property modifying particles in an amount up to 30 weight percent of the total particles.
Claim 24
Dependent Claim
35 words
The method according to claim 21 wherein said water-swellable property modifying particles are selected from the group consisting of starch, modified starch, agarose, polyacrylamides, ion exchange and chelating particles, cellulosics, polymethacrylates, styrene-divinylbenzene copolymers, and chitosan.
Claim 25
Dependent Claim
13 words
The method according to claim 17 wherein said non-swellable particles are inorganic oxide.
Claim 26
Dependent Claim
14 words
The method according to claim 17 wherein said non-swellable particles are an organic compound.
Claim 27
Dependent Claim
13 words
The method according to claim 17 wherein said non-swellable particles are a polymer.
Claim 28
Dependent Claim
18 words
The method according to claim 17 wherein said non-swellable particles are at least one of silica and zirconia.
Claim 29
Dependent Claim
12 words
The method according to claim 17 wherein said non-swellable particles are silica.
Claim 30
Dependent Claim
16 words
The method according to claim 17 wherein said non-swellable particles are chelating or ion exchange particles.
Claim 31
Dependent Claim
18 words
The method according to claim 17 wherein said particles further comprise a layer of covalently bonded organic coating.
Claim 32
Dependent Claim
16 words
The method according to claim 17 wherein said particles further comprise a coating of non-swellable polymer.
Claim 33
Dependent Claim
17 words
The method according to claim 17 where said chromatographic article has been subjected to electron beam treatment.
Claim 34
Dependent Claim
12 words
The method according to claim 17, wherein said non-swellable particles are hydroxylapatite.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-05 | 1993-09-04 | 1994-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-05 | 1997-09-04 | 1998-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-05 | 2001-09-04 | 2002-03-06 | $7700.00 | Window Closed / Lapsed |