US4906237A
Expired / Lapsed
US
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Method of forming an improved hydrophilic coating on a polymer surface
Assignee: Astra Tech AB
•
Filing: 1988-08-24
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Granted: 1990-03-06
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Expires: 2008-08-24
Abstract
Abstract A method of forming an improved hydrophilic coating by applying on a non-reactive hydrophilic polymer surface layer an osmolality-increasing compound to produce a more stable hydrophilic surface and to produce a more slippery surface in wet condition. The polymer surface layer is treated with a solution having above 2% (weight/volume) of an osmolality increasing compound and then the solvent of the solution is evaporated. Osmolality increasing compounds are nontoxic organic or unorganic salts other than trihalogenids, mono- or di- saccharides or sugar alcohols. Preferred compounds are glucose, sorbitol, sodium chloride, sodium citrate, sodium bensoate, calcium chloride, potassium chloride, potassium iodide, potassium nitrate. The solution of the osmolality increasing compound contains preferably a polymer. Medical articles treated with the solution of osmolality increasing compounds according to the method above also relate to the invention.
Inventors
- 👤 Eva G. Johansson
- 👤 Jan M. R. Utas-Sjoberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:43
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; A61L29/14
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
79 words
A method of forming an improved hydrophilic coating on a substrate, comprising: (a) applying a non-reactive hydrophilic polymer layer to the substrate; (b) applying to the non-reactive hydrophilic polymer layer a solution comprising a solvent and at least 2% (weight per volume) of an osmolality-increasing compound selected from the group consisting of mono and disaccharides, sugar alcohols, and non-toxic organic and inorganic salts, with the proviso that the osmolality-increasing compound is not a trihalogenide; and (c) evaporating the solvent.
Claim 2
Independent Claim
79 words
A method of forming an improved hydrophilic coating on a substrate, comprising: (a) applying a non-reactive hydrophilic polymer layer to the substrate; (b) applying to the non-reactive hydrophilic polymer layer a solution comprising a solvent and at least 2% (weight per volume) of an osmolality-increasing compound selected from the group consisting of mono and disaccharides, sugar alcohols, and non-toxic organic and inorganic salts, with the proviso that the osmolality-increasing compound is not a trihalogenide; and (c) evaporating the solvent.
Claim 3
Dependent Claim
34 words
A method according to claim 1 wherein the osmolality-increasing compounds is selected from the group consisting of glucose, sorbitol, sodium chloride, sodium citrate, sodium benzoate, calcium chloride, potassium chloride, potassium iodide and potassium nitrate.
Claim 4
Dependent Claim
33 words
A method according to claim 1, wherein the osmolality-increasing compound is selected from the group consisting of glucose, sodium chloride, sodium citrate, sodium benzoate, calcium chloride, potassium chloride, potassium iodide and potassium nitrate.
Claim 5
Dependent Claim
13 words
A method according to claim 1, wherein the solution further comprises a polymer.
Claim 6
Dependent Claim
21 words
A method according to claim 1, wherein the solution contains about 4% to about 40% (weight to volume) of sodium chloride.
Claim 7
Dependent Claim
22 words
A method according to claim 1, further comprising the step of curing the polymer layer prior to treatment with the osmolality-increasing agent.
Claim 8
Dependent Claim
29 words
A method according to claim 1, wherein the polymer layer comprises a polymer selected from the group consisting of polyethuleneoxide, polyvinylpyrrolidone, polyvinyl compounds, polysaccharides, polyurethanes, polyacrylates and copolymers thereof.
Claim 9
Dependent Claim
20 words
A method according to claim 1, wherein the polymer layer comprises polyvinylpryyolidone, and the solution comprises 20% (weight/volume) sodium chloride.
Claim 10
Dependent Claim
27 words
A method according to claim 4, wherein the polymer contained in the solution is the same polymer as is used in the non-reactive hydrophilic polymer surface layer.
Claim 11
Dependent Claim
20 words
A method according to claim 1, wherein the osmolality-increasing compound is selected from the group consisting of glucose and sorbitol.
Claim 12
Dependent Claim
20 words
A method according to claim 10, wherein the osmolality-increasing compound is selected from the group consisting of glucose and sorbitol.
Claim 13
Dependent Claim
28 words
A method according to claim 1, wherein the osmolality-increasing compound is selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, potassium iodide and potassium nitrate.
Claim 14
Dependent Claim
29 words
A medical article according to claim 1, wherein the osmolality-increasing compound is selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, potassium iodide and potassium nitrate.
Claim 15
Dependent Claim
79 words
A medical article having a very low coefficient of friction when wetted with a water-based liquid comprising: (a) substrate, (b) a non-reactive hydrophilic polymer layer disposed on the surface of said substrate; and (c) an evaporated hydrophilic coating disposed on the polymer layer, said evaporated hydrophilic coating comprising an osmolality-increasing compound selected from the group consisting of non-toxic organic and inorganic salts, mono- and disaccharides, and sugar alcohols, with the proviso that the osmolality-increasing agent is not a trihalogenide.
Claim 16
Dependent Claim
79 words
A medical article having a very low coefficient of friction when wetted with a water-based liquid comprising: (a) substrate, (b) a non-reactive hydrophilic polymer layer disposed on the surface of said substrate; and (c) an evaporated hydrophilic coating disposed on the polymer layer, said evaporated hydrophilic coating comprising an osmolality-increasing compound selected from the group consisting of non-toxic organic and inorganic salts, mono- and disaccharides, and sugar alcohols, with the proviso that the osmolality-increasing agent is not a trihalogenide.
Claim 17
Dependent Claim
35 words
A medical article according to claim 14, wherein the osmolality-increasing compound is selected from the group consisting of glucose, sorbitol, sodium chloride, sodium citrate, sodium benzoate, calcium chloride, potassium chloride, potassium iodide, and potassium nitrate.
Claim 18
Dependent Claim
33 words
A medical article according to claim 14, wherein osmolality-increasing compound is selected from the group consisting of glucose, sodium chloride, sodium citrate, sodium benzoate, calcium chloride, potassium chloride, potassium iodide, and potassium nitrate.
Claim 19
Dependent Claim
10 words
A medical article according to claim 14 which is catheter.
Claim 20
Dependent Claim
12 words
A medical article according to claim 17 which is a urinary catheter.
Claim 21
Dependent Claim
24 words
A medical article according to claim 14, wherein the osmolality-increasing compound is selected from the group consisting of mono- and disaccharides and sugar alcohols.
Claim 22
Dependent Claim
21 words
A medical article according to claim 19, wherein the osmolality-increasing compound is selected from the group consisting of glucose and sorbitol.
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