US4900780A
Expired / Lapsed
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Acellular resuscitative fluid
Assignee: Masonic Medical Research Laboratory
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Filing: 1988-05-25
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Granted: 1990-02-13
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Expires: 2008-05-25
Abstract
Abstract An acelluar resuscitative fluid, useful as an artificial blood or blood substitute, is prepared from a modified, high molecular weight starch or a tetronic polyol prepared by the interaction of ethylenediamine and ethylene or propylene oxides, which are converted to their aldehyde form. This material is reacted with a stabilized, stroma free hemoglobin, which has been converted to an oxy-acid or diketone. The resulting solution, after purification, can be administered to an animal in the same manner as whole blood. If desired, the solution of the reaction product with the stabilized hemoglobin can be freeze-dried and later reconstituted by the addition of water to provide the administrable fluid.
Inventors
- 👤 Lawrence C. Cerny
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:20
CPC Classifications
C; C08; C08H; C08H1/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/61; C07; C07K; C07K14/00; C07K14/795; C07K14/805; A61K38/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
93 words
An acellular resuscitative fluid comprising the reaction product of: (a) A stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxyacids and diketones; and (b) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of: (1) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons; and (2) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine.
Claim 2
Dependent Claim
93 words
An acellular resuscitative fluid comprising the reaction product of: (a) A stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxyacids and diketones; and (b) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of: (1) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons; and (2) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine.
Claim 3
Dependent Claim
18 words
The acellular resuscitative fluid of claim 1 wherein the high polymer is in the form of a monoaldehyde.
Claim 4
Dependent Claim
18 words
The acellular resuscitative fluid of claim 1 wherein the high polymer is in the form of a dialdehyde.
Claim 5
Dependent Claim
18 words
The acellular resuscitative fluid of claim 1 wherein the high polymer is in the form of a trialdehyde.
Claim 6
Dependent Claim
18 words
The acellular resuscitative fluid of claim 1 wherein the high polymer is in the form of a tetraaldehyde.
Claim 7
Dependent Claim
29 words
The acellular resuscitative fluid of claim 1 wherein the high polymer is a hydroxyethyl starch modified by molecular substitution by hydroxyethylation to a degree of from 0.2 to 0.9.
Claim 8
Dependent Claim
33 words
The acellular resuscitative fluid of claim 1 wherein the high polymer is a Tetronic polymer which is a block copolymer of ethylene oxide and propylene oxide units reacted with an ethylene diamine base.
Claim 9
Dependent Claim
96 words
A powdered acellular resuscitative material formed by freeze-drying the reaction product of: (a) a stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxy-acids and diketones; and (b) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of: (1) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons; and (2) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine.
Claim 10
Dependent Claim
96 words
A powdered acellular resuscitative material formed by freeze-drying the reaction product of: (a) a stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxy-acids and diketones; and (b) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of: (1) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons; and (2) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine.
Claim 11
Dependent Claim
19 words
The powdered acellular resuscitative material of claim 8 wherein the high polymer is in the form of a monoaldehyde.
Claim 12
Dependent Claim
19 words
The powdered acellular resuscitative material of claim 8 wherein the high polymer is in the form of a dialdehyde.
Claim 13
Dependent Claim
19 words
The powdered acellular resuscitative material of claim 8 wherein the high polymer is in the form of a trialdehyde.
Claim 14
Dependent Claim
19 words
The powdered acellular resuscitative material of claim 8 wherein the high polymer is in the form of a tetraaldehyde.
Claim 15
Dependent Claim
30 words
The powdered acellular resuscitative material of claim 8 wherein the high polymer is a hydroxyethyl starch modified by molecular substitution by hydroxyethylation to a degree of from 0.2 to 0.9.
Claim 16
Dependent Claim
34 words
The powdered acellular resuscitative material of claim 8 wherein the high polymer is a Tetronic polymer which is a block copolymer of ethylene oxide and propylene oxide units reacted with an ethylene diamine base.
Claim 17
Independent Claim
102 words
A method for forming a powdered acellular resuscitative material comprising: a. reacting (1) A stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxyacids and diketones; and (2) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of: (a) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons; and (b) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine; and b. freeze-drying the resulting material.
Claim 18
Independent Claim
102 words
A method for forming a powdered acellular resuscitative material comprising: a. reacting (1) A stroma-free hemoglobin which has been modified to provide reactive groups selected from the class consisting of oxyacids and diketones; and (2) a high molecular weight polymer, having reactive aldehyde constituents, selected from the class consisting of: (a) hydroxyethyl starch having a molecular weight of from 60,000 to 450,000 daltons; and (b) a Tetronic polymer having a molecular weight of from 1,650 to 27,000 daltons which is a block copolymer formed by the addition of ethylene and propylene oxide units to ethylene diamine; and b. freeze-drying the resulting material.
Claim 19
Dependent Claim
16 words
The method of claim 15 wherein the high polymer is in the form of a monoaldehyde.
Claim 20
Dependent Claim
16 words
The method of claim 15 wherein the high polymer is in the form of a dialdehyde.
Claim 21
Dependent Claim
16 words
The method of claim 15 wherein the high polymer is in the form of a trialdehyde.
Claim 22
Dependent Claim
17 words
The method of claim 15 wherein the high polymer is in the form of a tetra aldehyde.
Claim 23
Dependent Claim
27 words
The method of claim 15 wherein the high polymer is a hydroxyethyl starch modified by molecular substitution by hydroxyethylation to a degree of from 0.2 to 0.9.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-02-12 | 1993-08-14 | 1994-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-12 | 1997-08-14 | 1998-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-12 | 2001-08-14 | 2002-02-13 | $7700.00 | Window Closed / Lapsed |