US4898926A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioelastomer containing tetra/penta-peptide units
Assignee: UAB Research Foundation
•
Filing: 1987-06-15
•
Granted: 1990-02-06
•
Expires: 2007-06-15
Abstract
Abstract A bioelastomer containing repeating units comprising elastomeric tetrapeptide or pentapeptide units or a mixture thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid residues and glycine residues, wherein said repeating units exist in a β-turn which comprises a polypentapeptide unit of the formula: --αPρΩG--.sub.n wherein P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; α is a peptide-forming residue of L-valine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys and L-Tyr; ρ is a peptide-forming residue of glycine or a peptide-forming residue of D-Glu, D-Asp, D-His, D-Lys and D-Tyr; and Ω is a peptide-forming residue of L-valine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys and L-Tyr; and wherein n is an integer of from 1 to 5,000; with the proviso that in at least one repeating pentapeptide unit of said bioelastomer, at least one of said α or Ω is a peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys and L-Tyr, or ρ is a peptide-forming residue selected from the group consisting of residues of D-Glu, D-Asp, D-His, D-Lys and D-Tyr.
Inventors
- 👤 Dan W. Urry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 10:54
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
243 words
A bioelastomer containing repeating units comprising elastomeric pentapeptide units or a mixture of tetrapeptide and pentapeptide units, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid residues and glycine residues, wherein said repeating units exist in β-turn which comprises a polypentapeptide unit of the formula: --αPρΩG-- wherein P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; α is a peptide-forming residue of L-valine, L-leucine, L-isoleucine, L-phenylalanine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys and L-Tyr and other ionizable pep-tide-forming L-amino acid residues. Ω is a peptide-forming residue of L-valine, L-leucine, L-isoleucine, L-phenylalanine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys, and L-Tyr and other ionizable peptide-forming L-amino acid residues; and ρ is a peptide-forming residue of glycine or a peptide-forming residue of D-Glu, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming L-amino acid residues; and wherein n is an integer of from 1 to 5,000; with the proviso that in at least one repeating pentapeptide unit of said bicelastomer, at least one of said α or Ω ia a peptide-forming residue selected from the group and L-Tyr and other ionizable peptide-forming L-amino acid residues, or ρ is a peptide-forming residue of glycine or a peptide-forming residue of D-Glu, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming L-amino acid residues.
Claim 2
Dependent Claim
243 words
A bioelastomer containing repeating units comprising elastomeric pentapeptide units or a mixture of tetrapeptide and pentapeptide units, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid residues and glycine residues, wherein said repeating units exist in β-turn which comprises a polypentapeptide unit of the formula: --αPρΩG-- wherein P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; α is a peptide-forming residue of L-valine, L-leucine, L-isoleucine, L-phenylalanine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys and L-Tyr and other ionizable pep-tide-forming L-amino acid residues. Ω is a peptide-forming residue of L-valine, L-leucine, L-isoleucine, L-phenylalanine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys, and L-Tyr and other ionizable peptide-forming L-amino acid residues; and ρ is a peptide-forming residue of glycine or a peptide-forming residue of D-Glu, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming L-amino acid residues; and wherein n is an integer of from 1 to 5,000; with the proviso that in at least one repeating pentapeptide unit of said bicelastomer, at least one of said α or Ω ia a peptide-forming residue selected from the group and L-Tyr and other ionizable peptide-forming L-amino acid residues, or ρ is a peptide-forming residue of glycine or a peptide-forming residue of D-Glu, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming L-amino acid residues.
Claim 3
Dependent Claim
20 words
The bioelastomer of claim 1, wherein α a peptide-forming residue of L-valine and Ω is a peptide-forming residue of Glu.
Claim 4
Dependent Claim
40 words
The bioelastomer of claim 1, wherein at least one of said α or Ω is a peptide-forming residue of L-Glu, L-Asp, L-His, L-Lys and L-Tyr present in said pentapeptide unit on average in every fifth repeating unit of said bioelastomer.
Claim 5
Dependent Claim
218 words
A bioelastomer containing repeating units comprising elastomeric tetrapeptide units or a mixture of pentapeptide and tetrapeptide repeating units, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobit amino acid residues and glycine residues, wherein said repeating units exist in a β-turn which comprises a polytetrapeptide unit of the formula: --VPφδ).sub.n wherein V is a peptide-forming residue of L-valine, or L-leucine, L-isoleucine, or L-phenylalanine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys, and L-Tyr and other ionizable peptide-forming L-amino acid residues; P is a peptide-forming residue of L-proline; φ is a peptide-forming residue of D-Glue, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming D-amino acid residues thereof; and δ id s prpyifr-forming residue of L-Glu, L-Asp, L-His, L-Lys and L-Tyr and other ionizable peptide-forming L-amino acid residues thereof; and wherein n is an integer of from 1 to 5,000; with the proviso that in at least one repeating polytetrapeptide unit of the bioelastomer, at least one of said φ or δ is a peptide-forming amino acid residue selected from the groups consisting of D-Glu, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming L-amino acid residues thereof; or L-Glu, L-Asp, L-His, L-Lys and L-Tyr and other ionizable peptide-forming L-amino acid residues thereof, respectively.
Claim 6
Dependent Claim
218 words
A bioelastomer containing repeating units comprising elastomeric tetrapeptide units or a mixture of pentapeptide and tetrapeptide repeating units, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobit amino acid residues and glycine residues, wherein said repeating units exist in a β-turn which comprises a polytetrapeptide unit of the formula: --VPφδ).sub.n wherein V is a peptide-forming residue of L-valine, or L-leucine, L-isoleucine, or L-phenylalanine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys, and L-Tyr and other ionizable peptide-forming L-amino acid residues; P is a peptide-forming residue of L-proline; φ is a peptide-forming residue of D-Glue, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming D-amino acid residues thereof; and δ id s prpyifr-forming residue of L-Glu, L-Asp, L-His, L-Lys and L-Tyr and other ionizable peptide-forming L-amino acid residues thereof; and wherein n is an integer of from 1 to 5,000; with the proviso that in at least one repeating polytetrapeptide unit of the bioelastomer, at least one of said φ or δ is a peptide-forming amino acid residue selected from the groups consisting of D-Glu, D-Asp, D-His, D-Lys and D-Tyr and other ionizable peptide-forming L-amino acid residues thereof; or L-Glu, L-Asp, L-His, L-Lys and L-Tyr and other ionizable peptide-forming L-amino acid residues thereof, respectively.
References Cited (Backward Citations)
US4500700A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-05 | 1993-08-07 | 1994-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-05 | 1997-08-07 | 1998-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-05 | 2001-08-07 | 2002-02-06 | $7700.00 | Window Closed / Lapsed |