US4898736A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for tablet preparation
Assignee: Merck and Co Inc
•
Filing: 1988-03-09
•
Granted: 1990-02-06
•
Expires: 2008-03-09
Abstract
Abstract Dose uniformity in formulations of highly potent drugs may be achieved by distributing a solution of the active ingredient over a directly compressible tableting vehicle with subsequent evaporation of the solvent, followed by tableting.
Inventors
- 👤 Ashok V. Katdare
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K9/2095
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
48 words
A process for the preparation of low dose (2S,12bS)-1',3'-dimethylspiro(1,3,4,6,7,12b-hexahydro-benzo-[2,3-a]quinolizin)-2,4'-(5',6'-dihydro-1'H-pyrimidine-2'(3'H)-one) tablets comprising the steps: dissolving (2S,12bS)-1',3'-dimethylspiro(1,3,4,6,7,12b-hexahydrobenzo]2,3-a]quinolizin)-2,4'-(5',6'-dihydro-1'H-pyrimidine-2'(3'H)-one) in a suitable easily evaporated solvent; mixing the solution with a directly compressible powder tableting vehicle; evaporating the solvent; adding a lubricant and other excipients if desired; and compressing the mixture into tablets.
Claim 2
Dependent Claim
48 words
A process for the preparation of low dose (2S,12bS)-1',3'-dimethylspiro(1,3,4,6,7,12b-hexahydro-benzo-[2,3-a]quinolizin)-2,4'-(5',6'-dihydro-1'H-pyrimidine-2'(3'H)-one) tablets comprising the steps: dissolving (2S,12bS)-1',3'-dimethylspiro(1,3,4,6,7,12b-hexahydrobenzo]2,3-a]quinolizin)-2,4'-(5',6'-dihydro-1'H-pyrimidine-2'(3'H)-one) in a suitable easily evaporated solvent; mixing the solution with a directly compressible powder tableting vehicle; evaporating the solvent; adding a lubricant and other excipients if desired; and compressing the mixture into tablets.
Claim 3
Dependent Claim
24 words
The process of claim 1 wherein the easily evaporated solvent is ethanol, methanol, acetone or tetrahydrofuran and the low dose is about 50-1000 μg.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-05 | 1993-08-07 | 1994-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-05 | 1997-08-07 | 1998-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-05 | 2001-08-07 | 2002-02-06 | $7700.00 | Window Closed / Lapsed |