US4897422A
Expired / Lapsed
US
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Lipoxygenase inhibiting compounds
Assignee: Abbott Laboratories
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Filing: 1987-02-10
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Granted: 1990-01-30
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Expires: 2007-02-10
Abstract
Abstract Compounds of the formula: ##STR1## where R 1 is amino or methyl; R 2 is C 1 -C 2 alkyl; R 3 is one or more substituents selected from hydrogen, halogen or trihalomethyl; R 4 is one or more substituents selected from hydrogen, halogen, trihalomethyl, C 1 to C 4 alkoxy or C 1 to C 4 alkyl; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C 1 to C 6 alkoyl are inhibitors of 5- and/or 12-lipoxygenase enzymes.
Inventors
- 👤 James B. Summers, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:16
CPC Classifications
C; C07; C07C; C07C275/00; C07C275/04; C07C275/20; C07C275/24; C07C275/64; A; A61; A61P; A61P11/00; A61P17/00; A61P27/00; A61P27/16; A61P29/00; A61P37/00; A61P37/08; A61P43/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
34 words
Compounds of the formula: ##STR6## wherein R 1 is amino; R 2 is C 1 -C 2 alkyl; R 3 and R 4 are hydrogen; and M is hydrogen or a pharmaceutically acceptable cation.
Claim 2
Dependent Claim
34 words
Compounds of the formula: ##STR6## wherein R 1 is amino; R 2 is C 1 -C 2 alkyl; R 3 and R 4 are hydrogen; and M is hydrogen or a pharmaceutically acceptable cation.
Claim 3
Dependent Claim
11 words
A compound according to claim 1, wherein R 2 is methyl.
Claim 4
Dependent Claim
15 words
A compound of the formula: ##STR7## wherein M is hydrogen or a pharmaceutically acceptable cation.
Claim 5
Dependent Claim
15 words
A compound of the formula: ##STR7## wherein M is hydrogen or a pharmaceutically acceptable cation.
Claim 6
Independent Claim
61 words
A method of inhibiting 5- and/or 12-lipoxygenase activity in a mammal in need of such treatment, comprising administering to such mammal a therapeutically effective amount of a compound of the formula: ##STR8## wherein R 1 is amino; R 2 is C 1 -C 2 alkyl; R 3 and R 4 are hydrogen; and M is hydrogen or a pharmaceutically acceptable cation.
Claim 7
Independent Claim
61 words
A method of inhibiting 5- and/or 12-lipoxygenase activity in a mammal in need of such treatment, comprising administering to such mammal a therapeutically effective amount of a compound of the formula: ##STR8## wherein R 1 is amino; R 2 is C 1 -C 2 alkyl; R 3 and R 4 are hydrogen; and M is hydrogen or a pharmaceutically acceptable cation.
Claim 8
Dependent Claim
11 words
The method according to claim 10, wherein R 2 is methyl.
Claim 9
Independent Claim
41 words
A method of inhibiting 5- and/or 12-lipoxygenase activity in a mammal in need of such treatment, comprising administering to such mammal a therapeutically effective amount of a compound of the formula: ##STR9## wherein M is hydrogen or a pharmaceutically acceptable cation.
Claim 10
Independent Claim
41 words
A method of inhibiting 5- and/or 12-lipoxygenase activity in a mammal in need of such treatment, comprising administering to such mammal a therapeutically effective amount of a compound of the formula: ##STR9## wherein M is hydrogen or a pharmaceutically acceptable cation.
References Cited (Backward Citations)
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Cited
US3890377A
Cited
FR2068420A1
Cited
US3928384A
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EP0196184A2
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US4738986A
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US4604407A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-29 | 1993-07-31 | 1994-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-29 | 1997-07-31 | 1998-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-29 | 2001-07-31 | 2002-01-30 | $7700.00 | Window Closed / Lapsed |