US4892877A
Expired / Lapsed
US
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Antitussive liquid compositions containing phenol
Assignee: Richardson Vicks Inc
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Filing: 1987-10-27
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Granted: 1990-01-09
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Expires: 2007-10-27
Abstract
Abstract Novel antitussive and anesthetic liquid compositions of matter for oral use comprising an effective oral antitussive drug and phenol; and method of using same.
Inventors
- 👤 James V. Sorrentino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 10:00
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/045; A61K31/05; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485; A61K9/00; A61K9/0087; A61K9/0095; A61P; A61P11/00; A61P11/14
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
70 words
A liquid pharmaceutical composition of matter for use in the treatment of coughs and associated sore throat, by direct swallowing, comprising, per 5-30 ml dose: (a) an aqueous-based orally acceptable pharmaceutical carrier; (b) an effective antitussive amount of dextromethorphan hydrobromide; (c) from about 10 to about 150 milligrams of phenol; and (d) from about 5 to about 25 volume/volume percent of co-solvent; said composition having a pH of about 5-9.
Claim 2
Dependent Claim
70 words
A liquid pharmaceutical composition of matter for use in the treatment of coughs and associated sore throat, by direct swallowing, comprising, per 5-30 ml dose: (a) an aqueous-based orally acceptable pharmaceutical carrier; (b) an effective antitussive amount of dextromethorphan hydrobromide; (c) from about 10 to about 150 milligrams of phenol; and (d) from about 5 to about 25 volume/volume percent of co-solvent; said composition having a pH of about 5-9.
Claim 3
Dependent Claim
25 words
The composition of claim 1 wherein said co-solvent in (d) is a member selected from the group consisting of ethyl alcohol, glycerin and propylene glycol.
Claim 4
Dependent Claim
18 words
The composition of claim 2 wherein (a) is from about 20 to about 40% by weight of water.
Claim 5
Independent Claim
91 words
A method of treating cough or cough and associated sore throat in a human afflicted with same which comprises orally administering to said human, by direct swallowing, of at least one 5-30 ml does of a liquid pharmaceutical composition of matter comprising, per 5-30 ml dose: (a) an aqueous-based orally acceptable pharmaceutical carrier; (b) an effective antitussive amount of dextromethorphan hydrobromide; (c) from about 10 to about 150 milligrams of phenol; and (d) from about 5 to about 25 volume/volume percent of co-solvent; said composition having a pH of about 5-9.
Claim 6
Independent Claim
91 words
A method of treating cough or cough and associated sore throat in a human afflicted with same which comprises orally administering to said human, by direct swallowing, of at least one 5-30 ml does of a liquid pharmaceutical composition of matter comprising, per 5-30 ml dose: (a) an aqueous-based orally acceptable pharmaceutical carrier; (b) an effective antitussive amount of dextromethorphan hydrobromide; (c) from about 10 to about 150 milligrams of phenol; and (d) from about 5 to about 25 volume/volume percent of co-solvent; said composition having a pH of about 5-9.
Claim 7
Dependent Claim
25 words
The method of claim 4 wherein said co-solvent in (d) is a member selected from the group consisting of ethyl alcohol, glycerin and propylene glycol.
Claim 8
Independent Claim
94 words
A method of treating colds and associated sore throat in a human afflicted with same which comprises orally administering to said human, by direct swallowing, of at least one 5-30 ml dose of a liquid pharmaceutical composition of matter comprising, per 5-30 ml dose: (a) from about 20 to about 75% of water by weight/volume; (b) an effective antitussive amount of dextromethorphan hydrobromide; (c) from about 50 to about 150 milligrams of phenol; and (d) from about 10 to about 20 volume percent of ethyl alcohol; said composition having a pH of about 6-7.
Claim 9
Independent Claim
94 words
A method of treating colds and associated sore throat in a human afflicted with same which comprises orally administering to said human, by direct swallowing, of at least one 5-30 ml dose of a liquid pharmaceutical composition of matter comprising, per 5-30 ml dose: (a) from about 20 to about 75% of water by weight/volume; (b) an effective antitussive amount of dextromethorphan hydrobromide; (c) from about 50 to about 150 milligrams of phenol; and (d) from about 10 to about 20 volume percent of ethyl alcohol; said composition having a pH of about 6-7.
Claim 10
Dependent Claim
18 words
The method of claim 6 wherein (a) is from about 20 to about 40% by weight of water.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-01-08 | 1993-07-10 | 1994-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-08 | 1997-07-10 | 1998-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-08 | 2001-07-10 | 2002-01-09 | $7700.00 | Window Closed / Lapsed |