US4892742A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release compositions with zero order release
Assignee: Hoffmann La Roche Inc
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Filing: 1985-11-18
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Granted: 1990-01-09
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Expires: 2005-11-18
Abstract
Abstract Pharmaceutical compositions for controlled release of water soluble drugs are disclosed. The compositions comprise a tablet core containing the drug and a water insoluble polymeric matrix surrounded with a rate controlling membrane coating.
Inventors
- 👤 Navnit H. Shah
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:53
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054; A61K9/2013; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
62 words
A controlled release composition in table form comprising (1) a core element comprising a 90-95% by weight of the tablet, said core comprising (a) 65-95% by weight of a water soluble active ingredient (b) 5-35% by weight of a water insoluble polymeric matrix; and (2) a membrane coating comprising 5-10% by weight of the tablet said membrane comprising a rate controlling polymer.
Claim 2
Dependent Claim
62 words
A controlled release composition in table form comprising (1) a core element comprising a 90-95% by weight of the tablet, said core comprising (a) 65-95% by weight of a water soluble active ingredient (b) 5-35% by weight of a water insoluble polymeric matrix; and (2) a membrane coating comprising 5-10% by weight of the tablet said membrane comprising a rate controlling polymer.
Claim 3
Dependent Claim
23 words
The composition of claim 1 wherein the insoluble polymeric matrix comprises a polymer selected from the group consisting of ethyl cellulose, and zein.
Claim 4
Dependent Claim
14 words
The composition of claim 2 wherein the polymeric matrix is a ethyl cellulose polymer.
Claim 5
Dependent Claim
17 words
The composition of claim 2 wherein the insoluble polymer matrix further contains an oil or wax-like material.
Claim 6
Dependent Claim
50 words
The composition of claim 4 wherein the oil or wax-like material comprises a member selected from the group consisting of stearic acid, stearyl alcohol, cetyl alcohol, fatty acids, long chain fatty alcohols, carnuba wax, beeswax, white wax, vegetable oil and fatty acid glycerides of C 6 -C 18 fatty acids.
Claim 7
Dependent Claim
30 words
The composition of claim 5 wherein the membrane coating is selected from the group consisting of ethyl cellulose and mixtures of ethyl cellulose and of hydroxypropyl methylcellulose or hydroxypropyl cellulose.
Claim 8
Dependent Claim
12 words
The composition of claim 6 wherein the membrane coating is ethyl cellulose.
Claim 9
Dependent Claim
13 words
The composition of claim 6 wherein the membrane coating further contains a plasticizer.
Claim 10
Dependent Claim
45 words
The composition of claim 6 wherein the plasticizer is selected from the group consisting of triacetin, propylene glycol, polyethylene glycol having a molecular weight of 200 to 800, dibutyl phthalate, dibutyl sebacate, fatty acid, vegetable oils and glycerides of C 6 -C 18 fatty acids.
Claim 11
Dependent Claim
18 words
The composition of claim 9 wherein the plasticizer is a triglyceride of C 6 -C 10 fatty acid.
References Cited (Backward Citations)
FR1290661A
Cited
US4140756A
Cited
US4459279A
Cited
US4309406A
Cited
US4252786A
Cited
EP0066505A1
Cited
WO1984002843A1
Cited
WO1984004674A1
Cited
EP0158277A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-08 | 1993-07-10 | 1994-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-08 | 1997-07-10 | 1998-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-08 | 2001-07-10 | 2002-01-09 | $7700.00 | Window Closed / Lapsed |