US4889722A
Expired / Lapsed
US
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Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
Assignee: Ethicon Inc
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Filing: 1988-02-19
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Granted: 1989-12-26
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Expires: 2008-02-19
Abstract
Abstract Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of a composition comprising tissue plasminogen activator.
Inventors
- 👤 Warren D. Sheffield
- 👤 Gere S. diZerega
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:38
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
54 words
A process for inhibiting post-surgical adhesion formation in mammals which comprises the topical locally effective administration to the injured tissue surface site of surgical trauma of an effective amount of a sterile composition including as an active ingredient tissue plasminogen activator, for a period of time sufficient to inhibit the formation of post-surgical adhesions.
Claim 2
Dependent Claim
54 words
A process for inhibiting post-surgical adhesion formation in mammals which comprises the topical locally effective administration to the injured tissue surface site of surgical trauma of an effective amount of a sterile composition including as an active ingredient tissue plasminogen activator, for a period of time sufficient to inhibit the formation of post-surgical adhesions.
Claim 3
Dependent Claim
21 words
The process of claim 1 wherein such administration is made to the injured tissue site prior to closing the surgical field.
Claim 4
Dependent Claim
17 words
The process of claim 1 wherein the active ingredient is contained in a pharmaceutically acceptable organic carrier.
Claim 5
Dependent Claim
11 words
The process of claim 3 wherein said carrier is a phospholipid.
Claim 6
Dependent Claim
12 words
The process of claim 3 wherein said carrier is a phospholipid vesicle.
Claim 7
Dependent Claim
12 words
The process of claim 3 wherein said carrier is an absorbable polymer.
Claim 8
Dependent Claim
16 words
The process of claim 1 wherein said period is from about one hour to seven days.
Claim 9
Dependent Claim
20 words
The process of claim 1 wherein the active ingredient is contained in an aqueous solution of a surface active agent.
Claim 10
Dependent Claim
17 words
The process of claim 1 wherein the active ingredient is contained in an aqueous isotonic buffer solution.
Claim 11
Dependent Claim
33 words
The process of claim 1 wherein the tissue plasminogen activator is present in said composition at a concentration of at least about 0.015 milligram of tissue plasminogen activator per milliliter of said composition.
Claim 12
Dependent Claim
21 words
The process of claim 1 wherein the said composition comprises an aqueous solution or suspension of a pharmaceutically acceptable organic carrier.
Claim 13
Dependent Claim
13 words
The process of claim 11 wherein the organic carrier is a polymeric material.
Claim 14
Dependent Claim
12 words
The process of claim 11 wherein the organic carrier is a phospholipid.
Claim 15
Dependent Claim
18 words
The process of claim 11 wherein the organic carrier is a proteoglycan or water-soluble salt or ester thereof.
Claim 16
Dependent Claim
18 words
The process of claim 11 wherein the organic carrier is hyaluronic acid or water-soluble salt or ester thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-25 | 1993-06-26 | 1993-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-25 | 1997-06-26 | 1997-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-25 | 2001-06-26 | 2001-12-26 | $7700.00 | Window Closed / Lapsed |