US4888343A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions for relief of dysmenorrhea and/or premenstrual syndrome and process
Assignee: Bristol Myers Squibb Co
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Filing: 1986-09-15
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Granted: 1989-12-19
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Expires: 2006-09-15
Abstract
Abstract A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of aspirin or ibuprofen and a diuretic from the group pamabrom and hydrochlorothiazide; optionally it may also contain an antihistamine.
Inventors
- 👤 Howard Jones
- 👤 Alison B. Lukacsko
- 👤 Thomas M. Tencza
- 👤 Beth A. Sarsfield
- 👤 Mahesh K. Patel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 15:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/519; A61K31/52; A61K31/54; A61P; A61P13/00; A61P13/02; A61P15/00; A61P43/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
51 words
A pharmaceutical composition for the relief of dysmenorrhea and/or premenstrual syndrome consisting essentially of as the only pharmaceutically active ingredients (a) ibuprofen and (b) pamabrom, said pharmaceutically active ingredients (a) and (b) being present in the composition in amounts effective to afford relief from the symptoms of dysmenorrhea and/or premenstrual syndrome.
Claim 2
Dependent Claim
51 words
A pharmaceutical composition for the relief of dysmenorrhea and/or premenstrual syndrome consisting essentially of as the only pharmaceutically active ingredients (a) ibuprofen and (b) pamabrom, said pharmaceutically active ingredients (a) and (b) being present in the composition in amounts effective to afford relief from the symptoms of dysmenorrhea and/or premenstrual syndrome.
Claim 3
Dependent Claim
11 words
A pharmaceutical composition according to claim 1 including a pharmaceutical carrier.
Claim 4
Dependent Claim
34 words
A pharmaceutical composition according to claim 1 having as an average daily dose from about 100 mg to about 2 gm of ibuprofen and from about 5 mg to about 500 mg of pamabrom.
Claim 5
Dependent Claim
42 words
A pharmaceutical composition according to claim 3 in which the average daily dose for said ibuprofen is from about 200 mg to about 800 mg and the average daily dose for said pamabrom is from about 25 mg to about 200 mg.
Claim 6
Dependent Claim
35 words
A pharmaceutical composition according to claim 1 in unit dosage form containing from about 50 mg to about 1000 mg of said ibuprofen and from about 1 mg to about 100 mg of said pamabrom.
Claim 7
Dependent Claim
35 words
A pharmaceutical composition according to claim 5 in unit dosage form containing from about 100 mg to about 500 mg of said ibuprofen and from about 5 mg to about 50 mg of said pamabrom.
Claim 8
Dependent Claim
32 words
A pharmaceutical composition according to claim 1 also containing as an antihistamine, pyrilamine or a pharmaceutically acceptable salt thereof, said antihistamine also being present in said composition at an antihistamine effective level.
Claim 9
Dependent Claim
47 words
A pharmaceutical composition according to claim 7 having as an average daily dose from about 100 mg to about 2 gm of said ibuprofen, from about 5 mg to about 500 mg of said pamabrom and from about 15 mg to about 400 mg for said antihistamine.
Claim 10
Dependent Claim
47 words
A pharmaceutical composition according to claim 8 having as an average daily dose from about 200 mg to about 800 mg for said ibuprofen, from about 25 mg to about 200 mg of said pamabrom and from about 30 mg to about 200 mg for said antihistamine.
Claim 11
Dependent Claim
46 words
A pharmaceutical composition according to claim 7 in unit dosage form containing frm about 50 mg to about 1000 mg of said ibuprofen, from about 1 mg to about 100 mg of said pamabrom and form about 15 mg to about 50 mg of said antihistamine.
Claim 12
Dependent Claim
46 words
A pharmaceutical composition according to claim 10 in unit dosage form containing from about 100 mg to about 500 mg of said ibuprofen, from about 5 mg to about 50 mg of said pamabrom and from about 15 mg to about 50 mg of said antihistamine.
Claim 13
Dependent Claim
18 words
A pharmaceutical composition according to claims 7, 8, 9, 10 or 11, wherein said antihistamine is pyrilamine maleate.
Claim 14
Dependent Claim
16 words
A pharmaceutical composition according to claims 7, 8, 9, 10 or 11, including a pharmaceutical carrier.
Claim 15
Dependent Claim
45 words
A process for relieving symptoms of dysmenorrhea and/or premenstrual syndrome in a subject exhibiting such symptoms which comprises administering to said subject a composition of claims 1, 2, 3, 5, 6, 7, 8, 9, 10 or 11 in an amount sufficient to relieve said symptoms.
References Cited (Backward Citations)
EP0081823A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-18 | 1993-06-19 | 1993-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-18 | 1997-06-19 | 1997-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-18 | 2001-06-19 | 2001-12-19 | $7700.00 | Window Closed / Lapsed |