US4887604A
Expired / Lapsed
US
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Apparatus for performing dual energy medical imaging
Assignee: Science Research Laboratory
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Filing: 1988-05-16
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Granted: 1989-12-19
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Expires: 2008-05-16
Abstract
Abstract An energy substraction medical imaging system which is used for imaging a body part impregnated with a radio-opaque dye such as iodine is provided. The system includes an electron beam target having a target surface which, when excited by a high-energy electron beam, generates radiation having strong K.sub.α at energy levels slightly above and slightly below the K-edge energy level of the dye. The target surface is preferably formed of a compound containing lanthanum, such as lanthanum oxide. The target may also be formed of a compound containing a material having a K.sub.α line at an energy level slightly above the dye K-edge and a material with K.sub.α line slightly below the dye K-edge or with separate sections containing such materials which are alternately excited. The target is excited by a high-energy electron beam from a suitable source, the electron beam having sufficient energy to provide a high photon yield at the K.sub.α line energy levels and sufficient power to produce the required photon fluences at such energy lines for the medical imaging application. One of the K.sub.α lines in the radiation output from the excited target is selectively filtered and the output from the filter, both with the K.sub.α line filter and with the line unfiltered, are passed through the body part being imaged to an x-ray detector. The output from the detector in response to the filtered and unfiltered outputs is processed to obtain an image of the body part. Continuum radiation from the target is reduced by filtering the continuum radiation at frequencies above the below the K.sub.α line energy levels of the target compound, by viewing the radiation from the target in the backward direction to the beam, and by having the thickness of the target equal to a fraction of the electron range in the target compound material.
Inventors
- 👤 Ruth Shefer
- 👤 Robert E. Klinkowstein
- 👤 Richard Petrasso
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 00:43
CPC Classifications
A; A61; A61B; A61B6/00; A61B6/48; A61B6/482; A61B6/40; A61B6/4035; G; G21; G21K; G21K1/00; G21K1/10; H; H05; H05G; H05G1/00; H05G1/08; H05G1/26; H05G1/60; A61B6/4064; A61B6/4092
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
201 words
A dual energy medical imaging system for imaging a body part through which a radio-opaque dye is flowing, said dye having a predetermined K-edge energy level, comprising: an electron beam target having a target surface which, when excited by a high-energy electron beam, generates a radiation output having strong K.sub.α lines at energy levels slightly above and slightly below the K-edge energy level of the dye; means for appling an electron beam to excite said target, said beam having sufficient energy to provide a high photon yield at the K.sub.α line energy levels and sufficient power to obtain the photon fluence required for a medical imaging application; filter means for selectively either filtering or passing unfiltered at least one of the K.sub.α lines in the radiation output from the excited target surface; an x-ray detector; means for passing the output of said filter means with both said at least one K.sub.α line filtered and said at least one K.sub.α line unfiltered through the body part being imaged to said x-ray detector; and means for processing the energy received at the detector in response to the filtered and unfiltered outputs from the filtering means to obtain an image of the body part.
Claim 2
Dependent Claim
201 words
A dual energy medical imaging system for imaging a body part through which a radio-opaque dye is flowing, said dye having a predetermined K-edge energy level, comprising: an electron beam target having a target surface which, when excited by a high-energy electron beam, generates a radiation output having strong K.sub.α lines at energy levels slightly above and slightly below the K-edge energy level of the dye; means for appling an electron beam to excite said target, said beam having sufficient energy to provide a high photon yield at the K.sub.α line energy levels and sufficient power to obtain the photon fluence required for a medical imaging application; filter means for selectively either filtering or passing unfiltered at least one of the K.sub.α lines in the radiation output from the excited target surface; an x-ray detector; means for passing the output of said filter means with both said at least one K.sub.α line filtered and said at least one K.sub.α line unfiltered through the body part being imaged to said x-ray detector; and means for processing the energy received at the detector in response to the filtered and unfiltered outputs from the filtering means to obtain an image of the body part.
Claim 3
Dependent Claim
31 words
A system as claimed in claim 1 wherein said radio-opaque dye contains iodine having a K-edge at 33.16 KeV; and wherein said target surface is formed of a compound containing lanthanum.
Claim 4
Dependent Claim
13 words
A system as claimed in claim 2 wherein said compound is lanthanum oxide.
Claim 5
Dependent Claim
33 words
A system as claimed in claim 1 wherein said radio-opaque dye contains iodine having a K-edge at 33.16 KeV; and wherein said target surface is formed of a compound containing barium and cerium.
Claim 6
Dependent Claim
89 words
A system as claimed in claim 1 wherein a selected part of said target surface is covered with a first compound generating a strong K.sub.α line at an energy level slightly above the K-edge energy level of the dye and another selected part of the target surface is covered with a second compound generating a strong K.sub.α line at an energy level slightly below said K-edge energy level; and further comprising means for rotating the target surface to alternatively apply the electron beam to said first and second compounds.
Claim 7
Dependent Claim
20 words
A system as claimed in claim 5 wherein said first compound contains cerium and wherein said second compound contains barium.
Claim 8
Dependent Claim
19 words
A system as claimed in claim 1 wherein the energy of said electron beam is greater than 80 KeV.
Claim 9
Dependent Claim
19 words
A system as claimed in claim 1 wherein the energy of said electron beam is greater than 500 KeV.
Claim 10
Dependent Claim
18 words
A system as claimed in claim 8 wherein said electron beam has an energy of approximately 1 MeV.
Claim 11
Dependent Claim
25 words
A system as claimed in claim 9 wherein said electron beam has an average current over a 5 mS period of 0.5 to 1 amp.
Claim 12
Dependent Claim
19 words
A system as claimed in claim 1 wherein said electron beam applying means includes a radio frequency accelerating resonator.
Claim 13
Dependent Claim
17 words
A system as claimed in claim 2 further including means for reducing continuum radiation from the target.
Claim 14
Dependent Claim
31 words
A system as claimed in claim 12 wherein said means for reducing includes means for filtering continuum radiation from the target at frequencies above and below the K.sub.α line energy levels.
Claim 15
Dependent Claim
25 words
A system as claimed in claim 12 wherein said means for reducing includes means for viewing the radiation from the target in the backward direction.
Claim 16
Dependent Claim
36 words
A system as claimed in claim 12 wherein said means for reducing includes the thickness of the compound used for said target being thinner than R, where R equals one electron range in the compound material.
Claim 17
Dependent Claim
15 words
A system as claimed in claim 15 wherein the target thickness is 0.1 to 0.3R.
Claim 18
Dependent Claim
15 words
A system as claimed in claim 1 including means for protecting the target from overheating.
Claim 19
Dependent Claim
18 words
A system as claimed in claim 17 wherein said means for protecting includes means for rotating the target.
Claim 20
Dependent Claim
51 words
A system as claimed in claim 17 wherein said means for protecting includes forming said target surface thin enough so that electrons of the electron beam pass through the surface before they sustain large energy loss, and a backing means for said target surface, said backing means having good thermal properties.
Claim 21
Dependent Claim
134 words
A system as claimed in claim 1 wherein said means for filtering filters the higher energy K.sub.α line, resulting in an unfiltered image having energy I 1 =I L +I H ; and a filtered image having an energy I 2 =I L ; where I L and I H are the energy received at the lower energy K.sub.α line and the energy received at the higher energy K.sub.α line respectively; and wherein said means for processing determines the difference image by use of the equation D=wln (I L /I LO )-1n (I H /I HO ) where: I LO and I HO are energy incident at the low energy K.sub.α line and the high energy K.sub.α line respectively; w is the ratio of the high energy to the low energy tissue attenuation coefficient.
Claim 22
Independent Claim
175 words
A method for performing coronary angiography on a subject comprising the steps of: placing an iodine dye at an appropriate point in the bloodstream of the subject, the iodine having a predetermined K-edge energy level; exciting a target formed of a compound containing lanthanum with a high energy electron beam, the lanthanum generating strong K.sub.α lines in response to the exciting electron beam at an energy level slightly above the iodine K-edge level and a level slightly below the iodine K-edge level; viewing radiation from said excited target in the backward direction; selectively filtering the emitted radiation to remove energy emitted at a high K.sub.α line of the lanthanum target radiation; successively passing the filtered and unfiltered radiation from the target through a part of the subject's body to be imaged to a detector; and processing the detected radiation to determine the intensity in a difference image which represents the iodinated portion of the imaged body part; whereby an image of the part of the subject s body containing the iodine dye may be obtained.
Claim 23
Independent Claim
175 words
A method for performing coronary angiography on a subject comprising the steps of: placing an iodine dye at an appropriate point in the bloodstream of the subject, the iodine having a predetermined K-edge energy level; exciting a target formed of a compound containing lanthanum with a high energy electron beam, the lanthanum generating strong K.sub.α lines in response to the exciting electron beam at an energy level slightly above the iodine K-edge level and a level slightly below the iodine K-edge level; viewing radiation from said excited target in the backward direction; selectively filtering the emitted radiation to remove energy emitted at a high K.sub.α line of the lanthanum target radiation; successively passing the filtered and unfiltered radiation from the target through a part of the subject's body to be imaged to a detector; and processing the detected radiation to determine the intensity in a difference image which represents the iodinated portion of the imaged body part; whereby an image of the part of the subject s body containing the iodine dye may be obtained.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-18 | 1993-06-19 | 1993-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-18 | 1997-06-19 | 1997-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-18 | 2001-06-19 | 2001-12-19 | $7700.00 | Window Closed / Lapsed |