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US4886740A
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Enzyme-electrode sensor with organosilane treated membrane
Assignee: University of Manchester
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Filing: 1986-05-28
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Granted: 1989-12-12
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Expires: 2006-05-28
Abstract
Abstract A membrane for an enzyme-electrode type sensor treated to increase the range of linearity of the sensor response.
Inventors
- 👤 Pankaj M. Vadgama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:39
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0093; B01D67/00931; C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/002; Y; Y10; Y10S; Y10S435/00; Y10S435/817
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
97 words
A sensor of the enzyme-electrode type, comprising a sensor and a membrane thereon which is permeable to liquids and solutes, wherein the membrane comprises a first layer of polymeric material forming that face of the membrane which is nearer to the sensor, an enzyme-containing layer, and at least one further layer of polymeric material on that side of the enzyme-containing layer which is remote from said first layer, at least one of said at least one further layers being of a type which has been treated by being exposed to contact with a medium containing an organosilane.
Claim 2
Dependent Claim
97 words
A sensor of the enzyme-electrode type, comprising a sensor and a membrane thereon which is permeable to liquids and solutes, wherein the membrane comprises a first layer of polymeric material forming that face of the membrane which is nearer to the sensor, an enzyme-containing layer, and at least one further layer of polymeric material on that side of the enzyme-containing layer which is remote from said first layer, at least one of said at least one further layers being of a type which has been treated by being exposed to contact with a medium containing an organosilane.
Claim 3
Dependent Claim
24 words
A sensor according to claim 1, wherein the organosilane contains in the molecule at least one group which is reactive to polymerize the organosilane.
Claim 4
Dependent Claim
132 words
A sensor of the enzyme-electrode type, comprising: a sensor; and a membrane thereon which is permeable to liquids and solutes, wherein the membrane comprises a first layer of a polymeric material selected from the group comprising polymethyl methacrylate, polyurethane, cellulose acetate and other polymeric materials restricting the passage of electroactive interfering compounds, an enzyme-containing layer disposed on that side of the first layer which is remote from the sensor, and a second layer of polymeric material disposed on that side of the enzyme-containing layer which is remote from the first layer, said second layer being of a polymeric material selected from the group comprising polycarbonates and modified cellulose, said second layer of a type which has been treated by being exposed to contact with an organosilane having at least one halogen-containing group.
Claim 5
Dependent Claim
132 words
A sensor of the enzyme-electrode type, comprising: a sensor; and a membrane thereon which is permeable to liquids and solutes, wherein the membrane comprises a first layer of a polymeric material selected from the group comprising polymethyl methacrylate, polyurethane, cellulose acetate and other polymeric materials restricting the passage of electroactive interfering compounds, an enzyme-containing layer disposed on that side of the first layer which is remote from the sensor, and a second layer of polymeric material disposed on that side of the enzyme-containing layer which is remote from the first layer, said second layer being of a polymeric material selected from the group comprising polycarbonates and modified cellulose, said second layer of a type which has been treated by being exposed to contact with an organosilane having at least one halogen-containing group.
Claim 6
Dependent Claim
19 words
A sensor according to claim 3, wherein said organosilane is selected from the group comprising phenyltrichlorosilane, dimethyldichlorosilane and methyltrichlorosilane.
Claim 7
Dependent Claim
23 words
A sensor according to claim 3, wherein the polymeric material of said second layer has pores of average diameter less than 0.05 microns.
Claim 8
Independent Claim
136 words
A method for determining an analyte in a specimen, said method including the steps of contacting said specimen with the outermost layer of a membrane of an enzyme-electrode type sensor, and measuring the response of said sensor to species that are formed from said analyte by said enzyme, wherein the improvement comprises said membrane that is permeable to liquids and solutes and which includes (i) a first layer of polymeric material forming that face of the membrane which is nearest said sensor; (ii) a layer containing said enzyme; and (iii) at least one second layer of polymeric material, at least one of said at least one second layers having been exposed to contact with a medium containing an organosilane, wherein at least one of said organosilane contacted layers lies between said enzyme-containing layer and said specimen.
Claim 9
Independent Claim
136 words
A method for determining an analyte in a specimen, said method including the steps of contacting said specimen with the outermost layer of a membrane of an enzyme-electrode type sensor, and measuring the response of said sensor to species that are formed from said analyte by said enzyme, wherein the improvement comprises said membrane that is permeable to liquids and solutes and which includes (i) a first layer of polymeric material forming that face of the membrane which is nearest said sensor; (ii) a layer containing said enzyme; and (iii) at least one second layer of polymeric material, at least one of said at least one second layers having been exposed to contact with a medium containing an organosilane, wherein at least one of said organosilane contacted layers lies between said enzyme-containing layer and said specimen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-11 | 1993-06-12 | 1993-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-11 | 1997-06-12 | 1997-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-11 | 2001-06-12 | 2001-12-12 | $7700.00 | Window Closed / Lapsed |