US4885238A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immortalized human bronchial epitherial mesothelial cell lines
Assignee: United States Department of Health and Human Services
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Filing: 1987-10-30
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Granted: 1989-12-05
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Expires: 2007-10-30
Abstract
Abstract Immortalized human bronchial epithelial and human mesothelial cell lines have been obtained. Various uses of these cell lines have been described.
Inventors
- 👤 Roger R. Reddel
- 👤 Ke Yang
- 👤 Johng S. Rhim
- 👤 Douglas Brash
- 👤 Robert T. Su
- 👤 John F. Lechner
- 👤 Brenda I. Gerwin
- 👤 Curtis C. Harris
- 👤 Paul Amstad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 11:44
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0071; C12N5/00; C12N5/06; C12N5/0602; C12N5/0688; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/5005; G01N33/5008; G01N33/5011; G01N33/5014; G01N33/5017; C12N2500/00; C12N2500/90; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/948
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
47 words
Non-tumorigenic, human bronchial epithelial or mesothelial cell line or derivative thereof growing without senescence when cultured in vitro in growth medium, said cell lines being selected from the group consisting of those having the identifying characteristics of ATCC CRL 9608, 9609, 9442, 9443, 9444, 9482 and 9483.
Claim 2
Dependent Claim
47 words
Non-tumorigenic, human bronchial epithelial or mesothelial cell line or derivative thereof growing without senescence when cultured in vitro in growth medium, said cell lines being selected from the group consisting of those having the identifying characteristics of ATCC CRL 9608, 9609, 9442, 9443, 9444, 9482 and 9483.
Claim 3
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9608.
Claim 4
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9609.
Claim 5
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9442.
Claim 6
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9443.
Claim 7
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9444.
Claim 8
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9482.
Claim 9
Dependent Claim
13 words
The cell of claim 1 having the identifying characteristics of ATCC CRL 9483.
Claim 10
Dependent Claim
9 words
The cell of claim 1 further comprising an oncogene.
Claim 11
Dependent Claim
38 words
A kit for screening carcinogenic or chemotherapeutic agent comprising a container containing a non-tumorigenic, human bronchial epithelial or mesothelial cell line or derivative thereof according to claim 1 growing without senescence when cultured in vitro in growth medium.
Claim 12
Dependent Claim
47 words
A method for testing carcinogenicity of an agent, comprising culturing the cell line of claim 1 with an agent suspected of being carcinogenic and determining formation of abnormal cellular mass by said cell line, the formation of abnormal cellular mass being indicative of carcinogenicity of said agent.
Claim 13
Dependent Claim
45 words
A method for testing antineoplastic activity of an agent, comprising culturing the cell line of claim 1 with a potential antineoplastio agent and determining growth of said cell line, a lack of growth of said cell line being indicative of antineoplastic potency of said agent.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-12-04 | 1993-06-05 | 1993-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-12-04 | 1997-06-05 | 1997-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-12-04 | 2001-06-05 | 2001-12-05 | $7700.00 | Window Closed / Lapsed |