Restoration of impaired cardiac function of patients with diverse muscular dystrophies by therapy with coenzyme Q10

Abstract

Abstract The present invention relates to the use of Coenzyme Q in the treatment of slow muscle degeneration, commonly known to those of skill in the art so a dystrophy or atrophy, and the accompanying cardiac complications typically identified in such patients. Administration of Coenzyme Q, and particularly the analog Coenzyme Q10 (CoQ10) to humans increases the pumping of blood by the heart, and thereby increases tissue oxygeneration throughout the body. The net physiological effect halts the progression of muscle deterioration and improves cardiac function. An overall improvement in the quality of life for these human subjects is also observed, said patients reportedly experiencing less fatigue. A method for treating human patients with progressive muscular dystrophies or the neurogenic atrophies with Coenzyme Q10 (CoQ10) specifically disclosed. The method is similarly effective for the treatment of any form of muscle degeneration or cardiac muscular dysfunction independently.

Inventors

• 👤 Karl Folkers
• 👤 Janusz Wolaniuk

Bibliographic Details