US4883790A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Wavelength-specific cytotoxic agents
Assignee: University of British Columbia
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Filing: 1987-04-23
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Granted: 1989-11-28
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Expires: 2007-04-23
Abstract
Abstract A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-720 nanometers is useful in treating disorders which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light. The use of the Gp of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to receptor ligands or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
Inventors
- 👤 Julia G. Levy
- 👤 David Dolphin
- 👤 Jack K. Chow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:41
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/22; A; A61; A61K; A61K41/00; A61K41/0057; A61K41/0071; A61P; A61P35/00; A61K2121/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
118 words
A method to impair the functioning of target cells to which a hydro-monobenzoporphyrin (Gp) having a light absorption maximum between 670-720 nm is attracted, which method comprises administering to a mammal in need of such treatment an effective amount of said Gp; and irradiating said target cells with radiation having a wavelength contained in the range of 670-720 nm, wherein the Gp is selected from the group consisting of ##STR1## wherein each R 3 is independently [2-carboxyethyl or a derivative thereof] lower alkyl (1-4C) or omegacarboxyalkyl (2-6C) or the esters (1-6C) or amides (1-10C) thereof; and each R 1 and R 2 is independently selected from the group consisting of carboxy, carbalkoxy (1-6C), alkyl (1-6C) sulfone, and aryl.
Claim 2
Independent Claim
118 words
A method to impair the functioning of target cells to which a hydro-monobenzoporphyrin (Gp) having a light absorption maximum between 670-720 nm is attracted, which method comprises administering to a mammal in need of such treatment an effective amount of said Gp; and irradiating said target cells with radiation having a wavelength contained in the range of 670-720 nm, wherein the Gp is selected from the group consisting of ##STR1## wherein each R 3 is independently [2-carboxyethyl or a derivative thereof] lower alkyl (1-4C) or omegacarboxyalkyl (2-6C) or the esters (1-6C) or amides (1-10C) thereof; and each R 1 and R 2 is independently selected from the group consisting of carboxy, carbalkoxy (1-6C), alkyl (1-6C) sulfone, and aryl.
Claim 3
Dependent Claim
24 words
The method of claim 1 wherein each R 1 and R 2 is independently selected from the group consisting of carboxy and carbalkoxy (1-6C).
Claim 4
Dependent Claim
24 words
The method of claim 2 wherein each R 3 is independently selected from the group consisting of omegacarboxyalkyl (2-6C) and the esters (1-6C) thereof.
Claim 5
Dependent Claim
17 words
The method of claim 3 wherein the Gp has the formula selected from formulas 1 and 2.
Claim 6
Dependent Claim
17 words
The method of claim 3 wherein the Gp has the formula selected from formulas 3 and 4.
Claim 7
Dependent Claim
17 words
The method of claim 3 wherein the Gp has the formula selected from formulas 5 and 6.
Claim 8
Dependent Claim
16 words
The method of claim 1 wherein R 1 and/or R 2 is conjugated to a linker-moiety.
Claim 9
Dependent Claim
24 words
The method of claim 1 wherein each R 3 is independently selected from the group consisting of omegacarboxyalkyl (2-6C) and the esters (1-6C) thereof.
Claim 10
Dependent Claim
14 words
The method of claim 1 wherein the target cells are present on the skin.
Claim 11
Dependent Claim
12 words
The method of claim 9 wherein the target cells are superficial tumors.
Claim 12
Dependent Claim
33 words
The method of claim 9 wherein each R 1 and R 2 is selected from the group consisting of carboxy, carbalkoxy(1-6C), alkyl(1-6C) sulfonate, alkyl(1-6C) sulfone, and aryl, optionally conjugated to a linker moiety.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1992-11-27 | 1993-05-29 | 1993-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-27 | 1997-05-29 | 1997-11-28 | $3760.00 | Window Closed / Lapsed |
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