US4882335A
Expired / Lapsed
US
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Method for treating alcohol-drinking response
Assignee: Contral Clinics Oy
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Filing: 1988-06-13
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Granted: 1989-11-21
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Expires: 2008-06-13
Abstract
Abstract Described is the use of opiate antagonists for the preparation of pharmaceutical compositions to be administered simultaneously or separately sequentially with alcohol in the treatment of alcoholism. These pharmaceutical compositions are capable of extinguishing the alcohol-drinking response of alcoholics during a relatively short period of time by having the alcoholics drink alcoholic beverages repeatedly while the opiate antagonist contained in said pharmaceutical composition blocks the positive reinforcement effects of ethanol in the brain.
Inventors
- 👤 John D. Sinclair
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 04:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
101 words
A method for treating alcoholism by extinguishing the alcohol-drinking response, comprising the steps of: repeatedly administering to a subject suffering from alcoholism, an opiate antagonists selected from the group consisting of naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, nalorphine and salts thereof in a daily dosage sufficient to block the stimulatory effect of alcohol; while the amount of antagonist in the subject's body is sufficient to block the stimulatory effect of alcohol, having the subject drink an alcoholic beverage; and continuing the steps of administration of the opiate antagonist and drinking of an alcoholic beverage until the alcohol-drinking response is extinguished.
Claim 2
Independent Claim
101 words
A method for treating alcoholism by extinguishing the alcohol-drinking response, comprising the steps of: repeatedly administering to a subject suffering from alcoholism, an opiate antagonists selected from the group consisting of naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, nalorphine and salts thereof in a daily dosage sufficient to block the stimulatory effect of alcohol; while the amount of antagonist in the subject's body is sufficient to block the stimulatory effect of alcohol, having the subject drink an alcoholic beverage; and continuing the steps of administration of the opiate antagonist and drinking of an alcoholic beverage until the alcohol-drinking response is extinguished.
Claim 3
Dependent Claim
44 words
The method of claim 1 further comprising the step of punishing the patient after the alcoholic beverage is consumed, said step of punishment being selected from the group consisting of administration of electric shock, administration of emetics, and administration of an alcohol sensitizing compound.
Claim 4
Dependent Claim
14 words
The method of claim 2 wherein the alcohol sensitizing compound is disulfiram or cyanamide.
Claim 5
Dependent Claim
20 words
The method of claim 1 further comprising continuing the administration of an opiate antagonist after the alcohol-drinking response is extinguished.
Claim 6
Dependent Claim
13 words
The method in accordance with claim 1 wherein the opiate antagonist is naloxone.
Claim 7
Dependent Claim
19 words
The method in accordance with claim 5 wherein the dose of naloxone is from 0.2 to 30 mg daily.
Claim 8
Dependent Claim
13 words
The method in accordance with claim 1 wherein the opiate antagonist is naltrexone.
Claim 9
Dependent Claim
19 words
The method in accordance with claim 7 wherein the dose of naltrexone is from 20 to 300 mg daily.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-20 | 1993-05-22 | 1993-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-20 | 1997-05-22 | 1997-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-20 | 2001-05-22 | 2001-11-21 | $7700.00 | Window Closed / Lapsed |