US4882169A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Swellable pellets
Assignee: Haleon CH SARL
•
Filing: 1988-02-02
•
Granted: 1989-11-21
•
Expires: 2008-02-02
Abstract
Abstract Pellets which can be used in liquid oral formulations of drugs are presented. They comprise (a) a core, containing microparticles of at least one pharmaceutically active substance, (b) optionally one or more coating layer(s) and (c) a swellable outer layer. They are manufactured by methods known per se.
Inventors
- 👤 Kimon Ventouras
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:13
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K9/48; A61K9/50; A61K9/5073
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
95 words
Pellets comprising (a) a core, containing microparticles of at least one pharmaceutically active substance, (b) optionally one or more coating layer(s) and (c) an outer layer which rapidly swells and rapidly becomes jellified in contact with water containing a rapidly swelling and rapidly jellifying material selected from the group consisting of xanthan gum and derivatives thereof, guar gum and derivatives thereof, alginates, polysaccharides, cellulose derivatives, polyvinyl alcohol, pregelatinized starches and swellable acrylic polymers, which pellets, when contacted with water, are rapidly dispersed so as to generate a viscous, homogeneous suspension that can easily be swallowed.
Claim 2
Dependent Claim
95 words
Pellets comprising (a) a core, containing microparticles of at least one pharmaceutically active substance, (b) optionally one or more coating layer(s) and (c) an outer layer which rapidly swells and rapidly becomes jellified in contact with water containing a rapidly swelling and rapidly jellifying material selected from the group consisting of xanthan gum and derivatives thereof, guar gum and derivatives thereof, alginates, polysaccharides, cellulose derivatives, polyvinyl alcohol, pregelatinized starches and swellable acrylic polymers, which pellets, when contacted with water, are rapidly dispersed so as to generate a viscous, homogeneous suspension that can easily be swallowed.
Claim 3
Dependent Claim
21 words
Pellets according to claim 1, characterized in that the size of the microparticles used in the core (a) is 0.2-3.0 mm.
Claim 4
Dependent Claim
21 words
Pellets according to claim 1, characterized in that the size of the microparticles used in the core (a) is 0.3-1.5 mm.
Claim 5
Dependent Claim
21 words
Pellets according to claim 1, characterized in that the size of the microparticles used in the core (a) is 0.6-1.2 mm.
Claim 6
Dependent Claim
92 words
Pellets according to claim 1, characterized in that the pharmaceutically active substance incorporated into the core (a) is a member of the group consisting of drugs for the treatment of hypokaliaemia, psychotherapy drugs, non-steroidal antiinflammatory drugs, drugs for the therapy of hypocalcemic states or for calcium supplementation, drugs for the treatment of osteoporosis, muscle relaxants, antihistaminica, bronchodilators, drugs for the treatment of venous diseases, antitussive drugs, antipyretics, vitamines, cardiovascular and vascular drugs, geriatric drugs, pediatric drugs, drugs useful to balance the hydroelectrolytes, antibiotic drugs, nootropica, anthelmintica and histamin H 2 receptor antagonists.
Claim 7
Dependent Claim
16 words
Pellets according to claim 1, characterized in that they contain one or more coating layer(s) (b).
Claim 8
Dependent Claim
14 words
Pellets according to claim 1, characterized in that they contain one coating layer (b).
Claim 9
Dependent Claim
21 words
Pellets according to claim 1, characterized in that the swellable material used in the swellable outer layer (c) is guar gum.
Claim 10
Dependent Claim
20 words
Pellets according to claim 1, characterized in that the swellable material used in the swellable outer layer (c) is hydroxypropylmethylcellulose.
Claim 11
Dependent Claim
12 words
A pharmaceutical preparation for oral administration comprising pellets according to claim 1.
Claim 12
Dependent Claim
15 words
A pharmaceutical preparation according to claim 10, characterized in that it is a dry suspension.
Claim 13
Dependent Claim
19 words
A dry suspension according to claim 11, characterized in that it in addition comprises granules of a swellable material.
Claim 14
Dependent Claim
9 words
A sachet containing a pharmaceutical preparation of claim 11.
Claim 15
Dependent Claim
9 words
A sachet containing a pharmaceutical preparation of claim 12.
References Cited (Backward Citations)
US3946110A
Cited
US4341759A
Cited
GB2086725A
Cited
EP0052076A1
Cited
GB2103486A
Cited
EP0076428A1
Cited
US4721619A
Cited
EP0153104A2
Cited
GB2166651A
Cited
EP0181564A1
Cited
WO1986004817A1
Cited
WO1986006626A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-20 | 1993-05-22 | 1993-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-20 | 1997-05-22 | 1997-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-20 | 2001-05-22 | 2001-11-21 | $7700.00 | Window Closed / Lapsed |