US4876097A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions for coating feeding stuff additives intended for ruminants and feeding stuff additives thus coated
Assignee: Rhone Poulenc Sante SA
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Filing: 1987-09-02
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Granted: 1989-10-24
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Expires: 2007-09-02
Abstract
Abstract A composition for coating a biologically active substance which is stable in a medium in which the pH is greater than or equal to 5 and which permits the release of the active substance in a medium in which the pH is less than or equal to 3.5, comprises a film-forming, water-insoluble binder which possesses controlled hydrophilicity and is optionally slightly sensitive to pH variations, and a substance which is sensitive to pH variations (e.g. an inorganic filler, simple aminated substance, basic polymer or copolymer, chitosan). Pellets for feeding to ruminants consist of a core containing the biologically active substance, e.g. methionine or lysine, coated with this substance.
Inventors
- 👤 Pierre Autant
- 👤 Andre Cartillier
- 👤 Raymond Pigeon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 03:13
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A23; A23K; A23K40/00; A23K40/30; A23K40/35; A23K50/00; A23K50/10; A61K9/501; A61K9/5015; A61K9/5026; A61K9/5042; A61K9/5052; Y; Y10; Y10S; Y10S426/00; Y10S426/807
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
210 words
A composition suitable for coating a bilogically active substance, which is stable at a pH greater than or equal to 5 and which permits the release of the biologically active substance at a pH less than or equal to 3.5, which composition comprises: 40 to 95% by weight of a film-forming, waterinsoluble binding agent which possesses controlled hydrophilicity and which may be slightly sensitive to pH variations, the said binding agent being selected from the group consisting of a combination of a water-insoluble filmforming cellulose derivative and an agent for controlling the hydrophilic/hydrophobic balance selected from the group consisting of polyols in a weight ratio of cellulose derivative to polyol of from 1:1 to 1.5:1; zein; and a combination of zein and an agent for controlling the hydrophilic/hydrophobic balance selected from the group consisting of water-insoluble cellulose derivative in a weight ratio of 2:1 to 10:1; and 60 to 5% by weight of a pH sensitive substance selected from the group consisting of a polymer or copolymer containing at least one basic amino group and having a nitrogen content between 2 and 14% selected from the group consisting of amino derivatives of cellulose, polymers of amino derivatives of acrylic and methacrylic acids, copolymers of styrene with a vinylpyridine, and chitosan.
Claim 2
Dependent Claim
210 words
A composition suitable for coating a bilogically active substance, which is stable at a pH greater than or equal to 5 and which permits the release of the biologically active substance at a pH less than or equal to 3.5, which composition comprises: 40 to 95% by weight of a film-forming, waterinsoluble binding agent which possesses controlled hydrophilicity and which may be slightly sensitive to pH variations, the said binding agent being selected from the group consisting of a combination of a water-insoluble filmforming cellulose derivative and an agent for controlling the hydrophilic/hydrophobic balance selected from the group consisting of polyols in a weight ratio of cellulose derivative to polyol of from 1:1 to 1.5:1; zein; and a combination of zein and an agent for controlling the hydrophilic/hydrophobic balance selected from the group consisting of water-insoluble cellulose derivative in a weight ratio of 2:1 to 10:1; and 60 to 5% by weight of a pH sensitive substance selected from the group consisting of a polymer or copolymer containing at least one basic amino group and having a nitrogen content between 2 and 14% selected from the group consisting of amino derivatives of cellulose, polymers of amino derivatives of acrylic and methacrylic acids, copolymers of styrene with a vinylpyridine, and chitosan.
Claim 3
Dependent Claim
29 words
Pellets in the form of microcapsules intended for oral administration to animals, comprising a core containing a biologically active substance protected by a coating composition according to claim 1.
Claim 4
Dependent Claim
21 words
Pellets according to claim 2, in which the coating composition represents between 5 and 60% by weight of the coated pellet.
Claim 5
Dependent Claim
18 words
Pellets according to claim 2, in which the biologically active substance is a drug, vitamin or amino acid.
Claim 6
Dependent Claim
15 words
Pellets according to claim 2, in which the biologically active substance is methionine or lysine.
Claim 7
Dependent Claim
16 words
A composition according to claim 1, which also contains a plasticizer for the said binding agent.
Claim 8
Dependent Claim
22 words
A composition according to claim 6, in which the binding agent comprises zein and includes triacetin as a plasticizer for said zein.
Claim 9
Dependent Claim
19 words
A composition according to claim 6, in which the said binding agent also comprises an additional hydrophobic film-forming polymer.
Claim 10
Dependent Claim
16 words
A composition according to claim 8, in which the said additional film-forming polymer is polyvinyl acetate.
Claim 11
Dependent Claim
20 words
A composition according to claim 1, in which the said polyol is glycerol, ethylene glycol, propylene glycol or dipropylene glycol.
Claim 12
Dependent Claim
23 words
A composition according to claim 1, which contains in addition a lamella filler selected from the group consisting of mica, talc and aluminum.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-23 | 1993-04-24 | 1993-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-23 | 1997-04-24 | 1997-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-23 | 2001-04-24 | 2001-10-24 | $7700.00 | Window Closed / Lapsed |