US4874949A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of measuring lung vascular function and transcapillary transport by the use of nonradioactive markers
Assignee: Vanderbilt University
•
Filing: 1987-09-14
•
Granted: 1989-10-17
•
Expires: 2007-09-14
Abstract
Abstract Infrared sensitive indicator-dilution tracer concentration, specifically, 1,2 propanediol, can be optically measured in blood drawn from the systemic arterial system to indicate lung vascular function and transcapillary transport, i.e. pulmonary blood flow, extravascular lung water, transcapillary permeability-surface area, fluid filtration coefficients, etc. that may be helpful in diagnosing lung diseases, particularly Adult Respiratory Distress Syndrome (ARDS).
Inventors
- 👤 Thomas R. Harris
- 👤 Robert L. Galloway, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:17
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/84; G01N21/85; A; A61; A61B; A61B5/00; A61B5/02; A61B5/026; A61B5/0261; G01N21/17; G01N2021/1746; G01N21/25
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
48 words
An indicator dilution method for measuring lung vascular function, said method comprising: injecting an indicator mixture which comprises 1, 2 propanediol into the circulatory system so that the mixture becomes diluted with blood, withdrawing a sample of arterial blood, measuring the transmittance of filtered light through the blood.
Claim 2
Dependent Claim
48 words
An indicator dilution method for measuring lung vascular function, said method comprising: injecting an indicator mixture which comprises 1, 2 propanediol into the circulatory system so that the mixture becomes diluted with blood, withdrawing a sample of arterial blood, measuring the transmittance of filtered light through the blood.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the filtered light is measured by infrared absorbance.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the indicator mixture comprises red blood cells labelled with sulfhemoglobin.
Claim 5
Dependent Claim
35 words
The method of claim 1 wherein the indicator mixture is present in an amount effective for measuring transmitted, filtered light at 0.800 microns, 0.620 microns, 4.0 microns and 9.1 microns for determining lung vascular function.
Claim 6
Independent Claim
94 words
A method of measuring microcirculatory changes caused by Adult Respiratory Distress Syndrome, said method comprising: injecting 1, 2 propanediol in an indicator mixture which may be comprised of ingredients selected from the group consisting of indocyanine green dye, red blood cells labelled with sulfhemoglobin and deuterated water into the circulatory system so that the mixture becomes diluted with blood, withdrawing a sample of arterial blood, and measuring the transmittance of filtered light through the blood, determining the relative concentrations of each ingredient in said indicator mixture, and computing parameters characteristic of lung microvascular function.
Claim 7
Independent Claim
94 words
A method of measuring microcirculatory changes caused by Adult Respiratory Distress Syndrome, said method comprising: injecting 1, 2 propanediol in an indicator mixture which may be comprised of ingredients selected from the group consisting of indocyanine green dye, red blood cells labelled with sulfhemoglobin and deuterated water into the circulatory system so that the mixture becomes diluted with blood, withdrawing a sample of arterial blood, and measuring the transmittance of filtered light through the blood, determining the relative concentrations of each ingredient in said indicator mixture, and computing parameters characteristic of lung microvascular function.
Claim 8
Dependent Claim
33 words
The method of claim 5 wherein the indicator mixture in an amount effective for measuring transmitted filtered light at 0.800 microns, 0.62 microns, 4.0 microns and 9.1 microns for determining lung vascular function.
Claim 9
Dependent Claim
69 words
An indicator dilution method for measuring lung vascular function, said method comprising: injecting an indicator mixture which comprises 1, 2 propanediol and an ingredient selected from the group consisting of indocyanine green dye, red blood cells labelled with sulfhemoglobin and deuterated water into the circulatory system so that the mixture becomes diluted with blood, withdrawing a sample of arterial blood, measuring the transmittance of filtered light through the blood.
Claim 10
Dependent Claim
69 words
An indicator dilution method for measuring lung vascular function, said method comprising: injecting an indicator mixture which comprises 1, 2 propanediol and an ingredient selected from the group consisting of indocyanine green dye, red blood cells labelled with sulfhemoglobin and deuterated water into the circulatory system so that the mixture becomes diluted with blood, withdrawing a sample of arterial blood, measuring the transmittance of filtered light through the blood.
Claim 11
Dependent Claim
35 words
The method of claim 7 wherein the indicator mixture is present in an amount effective for measuring transmitted filtered light at 0.800 microns, 0.62 microns, 4.0 microns and 9.1 microns for determining lung vascular function.
References Cited (Backward Citations)
US3677648A
Cited
US4569589A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-16 | 1993-04-17 | 1993-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-16 | 1997-04-17 | 1997-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-16 | 2001-04-17 | 2001-10-17 | $7700.00 | Window Closed / Lapsed |