US4873186A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cornea storage medium
Assignee: Johns Hopkins University
•
Filing: 1987-09-02
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Granted: 1989-10-10
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Expires: 2007-09-02
Abstract
Abstract A storage medium for isolated donor corneas comprising at least one compound capable of inhibiting corneal lactate production. The addition of a short chain fatty acid and/or a ketone body and precursors provides isolated corneas with an efficient fuel source and concurrently inhibits corneal lactate formation.
Inventors
- 👤 Chung-Ho Chen
- 👤 Sumi C. Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 10:21
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
64 words
A method of extending a time a surgical quality isolated cornea can be stored which comprises including in the corneal storage medium containing the stored cornea, an amount of at least one compound selected from the group consisting of short chain fatty acids, ketone bodies and ketogenic amino acids capable of inhibiting lactate production by said isolated cornea sufficient to inhibit said lactate production.
Claim 2
Independent Claim
64 words
A method of extending a time a surgical quality isolated cornea can be stored which comprises including in the corneal storage medium containing the stored cornea, an amount of at least one compound selected from the group consisting of short chain fatty acids, ketone bodies and ketogenic amino acids capable of inhibiting lactate production by said isolated cornea sufficient to inhibit said lactate production.
Claim 3
Dependent Claim
15 words
A method according to claim 1 wherein said compound is a short chain fatty acid.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein said compound is ketone body.
Claim 5
Dependent Claim
11 words
A method according to claim 1 wherein said compound is β-hydroxybutyrate.
Claim 6
Dependent Claim
14 words
A method according to claim 1 wherein said compound is a ketogenic amino acid.
Claim 7
Independent Claim
65 words
A method of extending a time a surgical quality isolated cornea can be stored which comprises including in the corneal storage medium containing the stored cornea, an amount of at least one compound selected from the group consisting of short chain fatty acids and ketone bodies and ketone body precursors capable of inhibiting lactate production by said isolated cornea sufficient to inhibit said lactate production.
Claim 8
Independent Claim
65 words
A method of extending a time a surgical quality isolated cornea can be stored which comprises including in the corneal storage medium containing the stored cornea, an amount of at least one compound selected from the group consisting of short chain fatty acids and ketone bodies and ketone body precursors capable of inhibiting lactate production by said isolated cornea sufficient to inhibit said lactate production.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-09 | 1993-04-10 | 1993-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-09 | 1997-04-10 | 1997-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-09 | 2001-04-10 | 2001-10-10 | $7700.00 | Window Closed / Lapsed |