US4871842A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperidine derivatives
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1988-07-14
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Granted: 1989-10-03
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Expires: 2008-07-14
Abstract
Abstract Novel compounds of the formula: ##STR1## [wherein A is an α-amino acid residue; B is a group represented by the formula: ##STR2## (wherein R 4 is hydrogen, lower alkyl, aralkyl or amino-lower alkyl), whereby the linkage between the symbols A and B designates a peptide bond and the group R 4 in B may be linked with A; R 1 is hydrogen, lower alkyl or aralkyl; R 2 is hydrogen, lower alkyl, aralkyl or acyl; X is alkylene] and salts thereof possess, for example, inhibitory activity on angiotensin converting enzyme, and are useful as an agent for diagnosis, prevention or treatment of hypertension as well as circulatory diseases such as cardiopathy and cerebral apoplexy.
Inventors
- 👤 Hirosada Sugihara
- 👤 Kohei Nishikawa
- 👤 Katsumi Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:51
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
59 words
A compound of the formula: ##STR173## wherein A--B is a group represented by the formula: ##STR174## wherein R 4 is lower alkyl; R 1 is hydrogen, lower alkyl or phenyl-lower alkyl; R 2 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, benzoyl, phenyl-lower alkoxycarbonyl or lower alkoxycarbonyl; and X is C 1-7 alkylene; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
59 words
A compound of the formula: ##STR173## wherein A--B is a group represented by the formula: ##STR174## wherein R 4 is lower alkyl; R 1 is hydrogen, lower alkyl or phenyl-lower alkyl; R 2 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, benzoyl, phenyl-lower alkoxycarbonyl or lower alkoxycarbonyl; and X is C 1-7 alkylene; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
21 words
A compound according to claim 1, wherein A--B is a group represented by the ##STR175## wherein R 4' is lower alkyl.
Claim 4
Dependent Claim
10 words
A compound according to claim 1, which is (S)-2-[N-[N-[(S)-1-carboxy-5-(4-piperidyl)pentyl]-L-alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.
Claim 5
Dependent Claim
10 words
A compound according to claim 1, which is 3(RS)-[5-(4-piperidyl)-1-(RS)-carboxypentyl]amino-2-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-acetic acid.
Claim 6
Dependent Claim
10 words
A compound according to claim 1, which is (S,S,S)-2-[N-[1(S)-5-(4-piperidyl)-1-carboxypentyl]-L-alanyl]-2-azabicyclo[3,3,0octane-3-carboxylic acid.
Claim 7
Dependent Claim
14 words
A compound according to claim 1, wherein R 1 is hydrogen or lower alkyl.
Claim 8
Dependent Claim
11 words
A compound according to claim 1, wherein R 2 is hydrogen.
Claim 9
Dependent Claim
13 words
A compound according to claim 1, wherein X is trimethylene, tetramethylene or pentamethylene.
Claim 10
Dependent Claim
10 words
A compound according to claim 1, wherein X is tetramethylene.
Claim 11
Dependent Claim
11 words
A compound according to claim 1, wherein R 1 is hydrogen.
References Cited (Backward Citations)
EP0046953A2
Cited
JPS59231052A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |