US4871733A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cough/cold mixtures comprising non-sedating antihistamine drugs
Assignee: Analgesic Associates
•
Filing: 1988-08-11
•
Granted: 1989-10-03
•
Expires: 2008-08-11
Abstract
Abstract Pharmaceutical compositions and methods of using same comprising a non-steroidal anti-inflammatory drug in combination with a non-sedating antihistamine and optionally one or more other active components selected from a decongestant, cough suppressant (antitussive) or expectorant are provided for the relief of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, headache, fever and general malaise associated therewith.
Inventors
- 👤 Abraham Sunshine
- 👤 Eugene M. Laska
- 👤 Carole E. Siegel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 09:03
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485; A61K31/185; A61K31/19; A61K31/44; A61K31/445; A61K31/455; A61K31/54; A61K31/60; A61K45/00; A61K45/06
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
114 words
A pharmaceutical composition of matter for use in the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, fever and general malaise associated therewith, in a mammalian organism, and adapted for unit dosage oral administration, said composition comprising (i) and analgesically and anti-inflammatory effective amount of at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) an antihistaminically effective amount of at least one of the non-sedating antihistamines, AHR-11325, azelastine, ebastine, lodoxamide, levocabastine, mequitazine, oxatomide, setastine, tazifylline, or pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
114 words
A pharmaceutical composition of matter for use in the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, fever and general malaise associated therewith, in a mammalian organism, and adapted for unit dosage oral administration, said composition comprising (i) and analgesically and anti-inflammatory effective amount of at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) an antihistaminically effective amount of at least one of the non-sedating antihistamines, AHR-11325, azelastine, ebastine, lodoxamide, levocabastine, mequitazine, oxatomide, setastine, tazifylline, or pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
18 words
The pharmaceutical composition defined by claim 1, said non-steroidal anti-inflammatory drug comprising ibuprofen or pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
18 words
The pharmaceutical composition defined by claim 1, said non-steroidal anti-inflammatory drug comprising naproxen or pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
17 words
The pharmaceutical composition defined by claim 1, comprising at least 25 mg of said non-steroidal anti-inflammatory drug.
Claim 6
Dependent Claim
19 words
The pharmaceutical composition defined by claim 4, comprising from 25 mg to 600 mg of said non-steroidal anti-inflammatory drug.
Claim 7
Dependent Claim
21 words
The pharmaceutical composition defined by claim 2, comprising from 50 mg to 60 mg of ibuprofen or pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
19 words
The pharmaceutical composition defined by claim 6, comprising at least 100 mg of ibuprofen or pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
21 words
The pharmaceutical composition defined by claim 3, comprising from 125 mg to 500 mg of naproxen or pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
19 words
The pharmaceutical composition as defined by claim 1, comprising from 1 mg to 1000 mg of said non-sedating antihistamine.
Claim 11
Dependent Claim
16 words
The pharmaceutical composition as defined by claim 1, further comprising (iii) a pharmaceutically acceptable non-toxic carrier.
Claim 12
Dependent Claim
12 words
The pharmaceutical composition as defined by claim 1, in oral dosage form.
Claim 13
Dependent Claim
13 words
The pharmaceutical composition as defined by claim 11, in oral dosage tablet form.
Claim 14
Dependent Claim
13 words
The pharmaceutical composition as defined by claim 11, in oral dosage capsule form.
Claim 15
Dependent Claim
13 words
The pharmaceutical composition as defined by claim 11, in oral dosage suspension form.
Claim 16
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is AHR-11325.
Claim 17
Dependent Claim
14 words
The pharmaceutical compositon as defined by claim 1, wherein said non-sedating antihistamine is azelastine.
Claim 18
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is ebastine.
Claim 19
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is lodoxamide.
Claim 20
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is levocabastine.
Claim 21
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is mequitazine.
Claim 22
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is oxatomide.
Claim 23
Dependent Claim
14 words
The pharmaceutical composition as defined by claim 1, wherein said non-sedating antihistamine is setastine.
Claim 24
Dependent Claim
14 words
The pharmaceutical composition is defined by claim 1, wherein said non-sedating antihistamine is tazifylline.
Claim 25
Independent Claim
108 words
A method for the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, fever and general malaise associated therewith, in a mammalian organism in need of such treatment comprising administering to such organism a symptom relieving antihistaminically, analgesically and anti-inflammatory effective amount of a composition comprising (i) at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one non-sedating antihistamine AHR-11325, azelastine, ebastine, lodoxamide, levocabastine, mequitazine, oxatomide, setastine, tazifylline, or pharmaceutically acceptable salt thereof.
Claim 26
Independent Claim
108 words
A method for the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, fever and general malaise associated therewith, in a mammalian organism in need of such treatment comprising administering to such organism a symptom relieving antihistaminically, analgesically and anti-inflammatory effective amount of a composition comprising (i) at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one non-sedating antihistamine AHR-11325, azelastine, ebastine, lodoxamide, levocabastine, mequitazine, oxatomide, setastine, tazifylline, or pharmaceutically acceptable salt thereof.
Claim 27
Dependent Claim
44 words
A method for the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, fever and general malaise associated therewith, in a mammalian organism in need of such treatment comprising administering to such organism the pharmaceutical composition as defined by claim 1.
Claim 28
Dependent Claim
44 words
A method for the treatment of cough, cold, cold-like and/or flu symptoms and the discomfort, pain, fever and general malaise associated therewith, in a mammalian organism in need of such treatment comprising administering to such organism the pharmaceutical composition as defined by claim 2.
Claim 29
Independent Claim
94 words
A method for the treatment of an allergic reaction in a mammalian organism in need of such treatment, comprising administering to such organism an allergic symptom relieving effective amount of a composition comprising (i) at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, microprofen, tioxaprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one of the non-sedating antihistamines, AHR-11325, azelastine, ebastine, lodoxamide, levocabastine, mequitazine, oxatomide, setastine, tazifylline, or pharmaceutically acceptable salt thereof.
Claim 30
Independent Claim
94 words
A method for the treatment of an allergic reaction in a mammalian organism in need of such treatment, comprising administering to such organism an allergic symptom relieving effective amount of a composition comprising (i) at least one of the propionic acid NSAIDs, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, microprofen, tioxaprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid or pharmaceutically acceptable salt thereof, in combinatory immixture with (ii) at least one of the non-sedating antihistamines, AHR-11325, azelastine, ebastine, lodoxamide, levocabastine, mequitazine, oxatomide, setastine, tazifylline, or pharmaceutically acceptable salt thereof.
Claim 31
Dependent Claim
14 words
The method as defined by claim 27, said allergic reaction comprising coryza or rhinitis.
Claim 32
Dependent Claim
14 words
The method as defined by claim 27, wherein said propionic acid NSAID is ibuprofen.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |