US4869906A
Expired / Lapsed
US
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Tricalcium phosphate for implant materials wherein the pores of the tricalciumphosphate are filled with antibiotic and amino acid
Assignee: Merck Patent GmbH
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Filing: 1987-04-17
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Granted: 1989-09-26
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Expires: 2007-04-17
Abstract
Abstract A resorbable porous tricalcium phosphate, in which the pores are sealed with a filler mixture of an antibiotic and a filler, in particular an amino acid, is particularly advantageous for use in the preparation of bone cements.
Inventors
- 👤 Elvira Dingeldein
- 👤 Helmut Wahlig
- 👤 Manfred Wotschokowsky
- 👤 Gu Moddelmog
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:16
CPC Classifications
A; A61; A61L; A61L27/00; A61L24/00; A61L24/001; A61L24/0015; A61L27/50; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/21; A61L2300/214; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/45; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
44 words
In a resorbable porous tricalcium phosphate suitable for use as an additive in implant materials comprising polyacrylates, polymethacrylates or mixtures thereof, pores of said tricalcium phosphate material being sealed with a physiologically tolerable absorbable filler, the improvement wherein said filler further comprises an antibiotic.
Claim 2
Dependent Claim
44 words
In a resorbable porous tricalcium phosphate suitable for use as an additive in implant materials comprising polyacrylates, polymethacrylates or mixtures thereof, pores of said tricalcium phosphate material being sealed with a physiologically tolerable absorbable filler, the improvement wherein said filler further comprises an antibiotic.
Claim 3
Dependent Claim
16 words
A tricalcium phosphate material according to claim 1, wherein said amino acid is threonine or arginine.
Claim 4
Dependent Claim
18 words
A tricalcium phosphate material according to claim 1, wherein said antibiotic is gentamicin, clindamycin, lincomycin, or mixtures thereof.
Claim 5
Dependent Claim
27 words
A tricalcium phosphate material according to claim 1, wherein the amount of said antibiotic is about 2-20% by weight based on the weight of the tricalcium phosphate.
Claim 6
Dependent Claim
23 words
A tricalcium phosphate material according to claim 1, wherein the amount of said filler exclusive of the antibiotic is about 0.5-5% by weight.
Claim 7
Dependent Claim
20 words
A tricalcium phosphate according to claim 1, in the form of particles having a particle size of about 2-300 μm.
Claim 8
Dependent Claim
59 words
In a process for preparing resorbable porous tricalcium phosphate suitable for use as an additive for implant materials comprising polyacrylates, polymethacrylates, or mixtures thereof, the improvement comprising sealing the pores of said tricalcium phosphate material with a resorbable physiologically tolerable filler by contacting said tricalcium phosphate material with a solution comprising an aminoglycoside antibiotic, an amino acid, and solvent.
Claim 9
Dependent Claim
59 words
In a process for preparing resorbable porous tricalcium phosphate suitable for use as an additive for implant materials comprising polyacrylates, polymethacrylates, or mixtures thereof, the improvement comprising sealing the pores of said tricalcium phosphate material with a resorbable physiologically tolerable filler by contacting said tricalcium phosphate material with a solution comprising an aminoglycoside antibiotic, an amino acid, and solvent.
Claim 10
Dependent Claim
24 words
A process according to claim 7, wherein said tricalcium phosphate material is suspended in said solution and further comprising spray drying the resultant suspension.
Claim 11
Dependent Claim
67 words
A kit for the preparation of a bone cement comprising a first package containing a prepolymer in particle form and a resorbable tricalcium phosphate material according to claim 1, and a second package containing a liquid monomer, said prepolymer and liquid monomer capable of forming a polyacrylate, a polymethyl acrylate, or mixtures thereof, and said first package containing about 5-30% by weight of said tricalcium phosphate material.
Claim 12
Dependent Claim
20 words
A kit according to claim 9, wherein said first package contains about 8-20% by weight of said tricalcium phosphate material.
Claim 13
Dependent Claim
39 words
A kit according to claim 9, wherein the contents of said first and second package are in a ratio of about 40 g of solid in said first package to about 20 ml of monomer in said second package.
Claim 14
Dependent Claim
35 words
An implantation material comprising a polymer of polyacrylates, polymethacrylates, or mixtures thereof a liquid monomer of acrylic and/or methacrylic acid ester and 3-20% by weight of a resorbable tricalcium phosphate material according to claim 1.
References Cited (Backward Citations)
US4373217A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-09-25 | 1993-03-27 | 1993-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-25 | 1997-03-27 | 1997-09-26 | $3760.00 | Window Closed / Lapsed |
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