US4869897A
Expired / Lapsed
US
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Photoprotection compositions comprising sorbohydroxamic acid
Assignee: Procter and Gamble Co
•
Filing: 1987-10-22
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Granted: 1989-09-26
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Expires: 2007-10-22
Abstract
Abstract Disclosed are pharmaceutical compositions comprising sorbohydroxamic acid, or pharmaceutically-acceptable salts thereof, which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of sorbohydroxamic acid together with tocopherol sorbate and/or sunscreens are also disclosed. Also disclosed is a method for using these compositions topically, prior to UV exposure, to prevent damage to skin caused by acute or chronic UV exposure.
Inventors
- 👤 Ranjit Chatterjee
- 👤 Stephen J. Kirchner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 11:29
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61Q; A61Q17/00; A61Q17/04; A61K8/40; A61K8/72; A61K8/81; A61K8/8135; A61K8/84; A61K8/89; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
126 words
A topical composition for protecting the skin against the damaging effects of UV radiation comprising a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and a safe and effective amount of a topical carrier which comprises one or more components selected from the group consisting of an organic solvent selected from the group consisting of propylene glycol, polyethylene glycol, polypropylene glycol, glycerol, 1,2,4-butane-triol, sorbitol esters, 1,2,6-hexanetriol, ethanol, isopropanol, and butanediol; a propellant selected from the group consisting of lower molecular weight hydrocarbon mixtures, ethers, and halohydrocarbons; an emollient; an ointment base selected from the group consisting of animal oil, vegetable oil, a semi-solid hydrocarbon, anhydrous, lanolin, and hydrophilic petrolatum; an emulsifier; and a surfactant.
Claim 2
Dependent Claim
126 words
A topical composition for protecting the skin against the damaging effects of UV radiation comprising a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and a safe and effective amount of a topical carrier which comprises one or more components selected from the group consisting of an organic solvent selected from the group consisting of propylene glycol, polyethylene glycol, polypropylene glycol, glycerol, 1,2,4-butane-triol, sorbitol esters, 1,2,6-hexanetriol, ethanol, isopropanol, and butanediol; a propellant selected from the group consisting of lower molecular weight hydrocarbon mixtures, ethers, and halohydrocarbons; an emollient; an ointment base selected from the group consisting of animal oil, vegetable oil, a semi-solid hydrocarbon, anhydrous, lanolin, and hydrophilic petrolatum; an emulsifier; and a surfactant.
Claim 3
Dependent Claim
28 words
The composition of claim 1 which comprises from about 1% to about 10% of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof.
Claim 4
Dependent Claim
28 words
The composition of claim 2 which comprises from about 1% to about 5% of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof.
Claim 5
Dependent Claim
16 words
The composition of claim 2 which comprises from about 85% to about 99% of the carrier.
Claim 6
Dependent Claim
11 words
The composition of claim 4 wherein the carrier comprises an emollient.
Claim 7
Dependent Claim
10 words
The composition of claim 5 wherein the emollient is glycerol.
Claim 8
Dependent Claim
34 words
The composition of claim 5 containing from about 1% to about 10% by weight of an emollient which comprises a propoxylated glycerol derivative having the formula: ##STR5## wherein n=1 or 2, and mixtures thereof.
Claim 9
Dependent Claim
50 words
The composition of claim 4 which additionally comprises from about 0.25% to about 3% of an ethylene acrylic acid copolymer having the formula ##STR6## wherein the ratio of x:y is from about 1:9 to about 1:24 and the molecular weight of the copolymer is from about 3500 to about 4500.
Claim 10
Dependent Claim
17 words
The composition of claim 4 which additionally comprises a safe and effective amount of a penetration enhancer.
Claim 11
Dependent Claim
18 words
The composition of claim 4 which additionally comprises a safe and photoprotectively effective amount of a sunscreening agent.
Claim 12
Dependent Claim
17 words
The composition of claim 10 which comprises from about 1% to about 10% of the sunscreening agent.
Claim 13
Dependent Claim
69 words
The composition of claim 11 wherein the sunscreening agent is selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4 methoxybenzophenone, octyldimethylp-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, the N,N-di-(2-ethylhexyl)-4-amino-benzoic acid ester of 4-hydroxydibenzoylmethane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-hydroxydibenzoyl-methane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone; the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)-dibenzoylmethane; the N-N-di-(2-ethylhexyl)4-aminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the N,N-di-(2-ethylhexyl)4-aminobenzoic acid ester of 4-(2-hydroxyethoxy)-dibenzoylmethane and mixtures thereof.
Claim 14
Dependent Claim
27 words
The composition of claim 8 which additionally comprises a sunscreening agent selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl-p-aminobenzoic acid and mixtures thereof.
Claim 15
Independent Claim
48 words
A method of inhibiting the deleterious effects of ultra-violet light exposure to skin comprising applying a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, to the skin in conjunction with exposing the skin to ultraviolet light.
Claim 16
Independent Claim
48 words
A method of inhibiting the deleterious effects of ultra-violet light exposure to skin comprising applying a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, to the skin in conjunction with exposing the skin to ultraviolet light.
Claim 17
Dependent Claim
36 words
The method of claim 14 wherein from about 0.01 mg/cm 2 to about 1.0 mg/cm 2 of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, is applied to the skin.
Claim 18
Dependent Claim
36 words
The method of claim 14 wherein from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, is applied to the skin.
Claim 19
Dependent Claim
34 words
The method of claim 14 wherein the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, is applied to the skin up to about 4 hours prior to UV exposure.
Claim 20
Independent Claim
58 words
A method of inhibiting the deleterious effects of ultraviolet exposure to skin comprising applying a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and safe and photoprotectively effective amount of a sunscreening agent to the skin simultaneously in conjunction with exposing the skin to ultraviolet light.
Claim 21
Independent Claim
58 words
A method of inhibiting the deleterious effects of ultraviolet exposure to skin comprising applying a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and safe and photoprotectively effective amount of a sunscreening agent to the skin simultaneously in conjunction with exposing the skin to ultraviolet light.
Claim 22
Dependent Claim
51 words
The method of claim 18 wherein from about 0.01 mg/cm 2 to about 1.0 mg/cm 2 of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and from about 0.01 mg/cm 2 to about 1.0 mg/cm 2 of the sunscreening agent is applied to the skin.
Claim 23
Dependent Claim
51 words
The method of claim 19 wherein from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 of the sunscreening agent is applied to the skin.
Claim 24
Dependent Claim
69 words
The method of claim 20 wherein the sunscreening agent is selected from the group consisting of 2-ethylhexyl p-methoxy-cinnamate, butylmethoxydibenzoylmethane, 2-hydroxy-4-methoxy-benzophenone, octyldimethyl-p-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2,4-dihydroxy-benzophenone, the N,N-di(2-ethylhexyl)4-aminobenzoic acid ester of 4-hydroxydibenzolmethane, the 4-N,N-(2-ethylhexyl)methyl-aminobenzoic acid ester of 4-hydroxydibenzoylmethane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy(benzophenone, the 4-N,N-(2-ethylhexyl) methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane, the N-N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, or the N,N-di(2-ethylhexyl)-4-aminobenzoic acid ester of 4-(2-hydroxy-ethoxy)di-benzoylmethane and mixtures thereof.
Claim 25
Dependent Claim
35 words
The method of claim 21 wherein the sunscreening agent is selected from the group consisting of 2-ethylhexyl-p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyl-dimethyl p-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the 4-N,N-2-ethylhexyl)methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)-dibenzoylmethane.
Claim 26
Dependent Claim
39 words
The method of claim 18 wherein the agent selected from the group consisting of sorbohydroxamic acid and the pharmaceutically-acceptable salts thereof, and the sunscreening agent are applied to the skin up to about 4 hours prior to UV exposure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-25 | 1993-03-27 | 1993-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-25 | 1997-03-27 | 1997-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-25 | 2001-03-27 | 2001-09-26 | $7700.00 | Window Closed / Lapsed |