US4869264A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electroencephalographic consciousness and anesthetic monitor
Assignee: Swinburne Ltd
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Filing: 1986-07-28
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Granted: 1989-09-26
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Expires: 2006-07-28
Abstract
Abstract A method and apparatus for testing the anesthetic depth or consciousness of a subject by directing visible red stimulus signals at the eyes of the subject through closed eyelids at accurately known frequencies. An electroencephalographic (EEG) signal is then obtained and a discriminator (18) is used to accurately detect components at the applied frequencies. An assessment is then made by comparing the magnitude or phase of the components of the EEG signal at the predetermined frequencies with correspondingly obtained EEG signals which have been obtained prior to administration of anesthetic to the subject.
Inventors
- 👤 Richard B. Silberstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:55
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/16; A61B5/24; A61B5/316; A61B5/369; A61B5/377; A61B5/378; A61B5/48; A61B5/4821
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
145 words
A method of testing anaesthetic depth or consciousness of a subject (2) having closed eyelids, comprising the steps of applying a stimulus signal (216) of visible red light, whose intensity is varied so as to include at least one component of a predetermined frequency (F 1 , F 2 , F 3 ), to at leat one closed eyelid of the subject, said stimulus signal (216) being perceptible to the subject (2) through said closed eyelid, obtaining an electroencephalographic (EEG) signal from the subject while said stimulus signal is being applied and perceived by the subject (2), analysing the EEG signal so as to determine the magnitude, or magnitude and phase of that component of the EEG signal which has said predetermined frequency, and assessing the anaesthetic depth or consciousness of the subject with reference to said magnitude, or magnitude and phase of the component.
Claim 2
Independent Claim
145 words
A method of testing anaesthetic depth or consciousness of a subject (2) having closed eyelids, comprising the steps of applying a stimulus signal (216) of visible red light, whose intensity is varied so as to include at least one component of a predetermined frequency (F 1 , F 2 , F 3 ), to at leat one closed eyelid of the subject, said stimulus signal (216) being perceptible to the subject (2) through said closed eyelid, obtaining an electroencephalographic (EEG) signal from the subject while said stimulus signal is being applied and perceived by the subject (2), analysing the EEG signal so as to determine the magnitude, or magnitude and phase of that component of the EEG signal which has said predetermined frequency, and assessing the anaesthetic depth or consciousness of the subject with reference to said magnitude, or magnitude and phase of the component.
Claim 3
Dependent Claim
59 words
A method as claimed in any one of claim 1 including the step of applying a stimulus signal having a plurality of predetermined frequency components therein and the analysis of the EEG signal is carried out to determine the magnitude, or magnitude and phase of the respective components in the EEG having the same frequencies as the stimulus signal.
Claim 4
Dependent Claim
22 words
A method as claimed in any one of claim 1 including the step of simultaneously applying selected groups of said frequency components.
Claim 5
Independent Claim
108 words
A method of testing anaesthetic depth or consciousness of a subject (2) comprising the steps of applying a stimulus signal (216) having a plurality of predetermined frequency components simultaneously therein, to a sensory organ of the subject, obtaining an electroencephalographic (EEG) signal from the subject while said stimulus is being applied, analysing the EEG signal so as to determine the magnitude, or magnitude and phase of the respective components of the EEG signal which have the same frequencies as said plurality of predetermined frequency components, and assessing the anaesthetic depth or consciousness of the subject with reference to said magnitude, or magnitude and phase of the respective components.
Claim 6
Independent Claim
108 words
A method of testing anaesthetic depth or consciousness of a subject (2) comprising the steps of applying a stimulus signal (216) having a plurality of predetermined frequency components simultaneously therein, to a sensory organ of the subject, obtaining an electroencephalographic (EEG) signal from the subject while said stimulus is being applied, analysing the EEG signal so as to determine the magnitude, or magnitude and phase of the respective components of the EEG signal which have the same frequencies as said plurality of predetermined frequency components, and assessing the anaesthetic depth or consciousness of the subject with reference to said magnitude, or magnitude and phase of the respective components.
Claim 7
Dependent Claim
23 words
A method as claimed in claim 4 wherein said plurality of frequency components have frequencies selected from the range 38 to 72 Hz.
Claim 8
Dependent Claim
63 words
A method as claimed in claim 4, including the step of obtaining a normal response (22, 32) for the subject by obtaining a normal electroencephalographic (EEG) signal from the subject prior to administering anaesthetic to the subject, and wherein said step of assessing the anaesthetic depth or consciousness includes the step of comparing the first mentioned EEG signal with said normal EEG signal.
Claim 9
Dependent Claim
20 words
A method as claimed in claim 6 including the step of graphically displaying said EEG signals or a ratio thereof.
Claim 10
Dependent Claim
14 words
A method as claimed in claim 6 wherein said stimulus signal comprises electromagnetic radiation.
Claim 11
Dependent Claim
28 words
A method as claimed in claim 8 wherein the radiation comprises visible red radiation modulated in intensity so as to have components as said plurality of predetermined frequencies.
Claim 12
Dependent Claim
20 words
A method as claimed in claim 9 wherein the predetermined frequencies are in the range from 4 to 72 Hz.
Claim 13
Dependent Claim
61 words
A method as claimed in claim 4 wherein the EEG signal from the subject is separately multiplied by the sine and cosine of each frequency component f n of the stimulus signal and then integrated as a function of time, and the magnitude M n of the EEG signal at frequency f n is determined by performing the following calculation: ##EQU4##
Claim 14
Dependent Claim
28 words
A method as claimed in claim 34 wherein the steps of multiplying by the sine and cosine of each frequency and the integration are performed in analogue form.
Claim 15
Dependent Claim
24 words
A method as claimed in claim 4 including the step of administering anaesthetic to the subject in accordance with the assessment of anaesthetic depth.
Claim 16
Dependent Claim
107 words
Apparatus for testing consciousness of a subject having closed eyelids, said apparatus comprising generator means (14) for generating a stimulus signal of visible red light, whose intensity is varied so as to have at least one component of a predetermined frequency, coupling means (16) for coupling the stimulus signal to at least one closed eyelid of the subject, said stimulus signal being perceptible to the subject through said closed eyelid, EEG electrodes (4, 6, 8, 10) for deriving an EEG signal from the subject and discriminating means (18) for obtaining magnitude, or magnitude and phase of that component of the EEG signal which has said predetermined frequency.
Claim 17
Dependent Claim
107 words
Apparatus for testing consciousness of a subject having closed eyelids, said apparatus comprising generator means (14) for generating a stimulus signal of visible red light, whose intensity is varied so as to have at least one component of a predetermined frequency, coupling means (16) for coupling the stimulus signal to at least one closed eyelid of the subject, said stimulus signal being perceptible to the subject through said closed eyelid, EEG electrodes (4, 6, 8, 10) for deriving an EEG signal from the subject and discriminating means (18) for obtaining magnitude, or magnitude and phase of that component of the EEG signal which has said predetermined frequency.
Claim 18
Dependent Claim
36 words
Apparatus as claimed in claim 14 wherein the coupling means comprises an LED array (16) for applying intensity modulated infra red signals to the eye or eyes of the subject through his closed eyelid or eyelids.
Claim 19
Dependent Claim
51 words
Apparatus as claimed in claim 15 wherein the generator means includes an intensity control circuit (90) which regulates the peak intensity of light emitted from the LED array, said intensity control circuit including a control LED (132) output from which provides negative feedback for controlling driving current to the LED array.
Claim 20
Dependent Claim
20 words
Apparatus as claimed in claim 15 wherein the LED array is coupled to the intensity control circuit via an optocoupler.
Claim 21
Dependent Claim
18 words
Apparatus as claimed in claim 17 wherein the LED array is located within a shielding screen (138, 140).
Claim 22
Dependent Claim
23 words
Apparatus as claimed in claim 15 wherein the LED array is in two portions which overlie in use respective eyes of the subject.
Claim 23
Dependent Claim
17 words
Apparatus as claimed in claim 19 wherein said portions are mounted on goggles or a spectacle frame.
Claim 24
Dependent Claim
54 words
Apparatus as claimed in claim 14 wherein the generator means generates a plurality of predetermined frequency components (F 1 , F 2 , F 3 ) which are, in use, simultaneously applied to the subject and the discriminating means determines the magnitude, or magnitude and phase of the respective components of the EEG signal.
Claim 25
Dependent Claim
88 words
Apparatus for testing consciousness of a subject, said apparatus comprising generator means (14) for generating a stimulus signal having a plurality of predetermined frequency components simultaneously therein, coupling means (16) for coupling the stimulus signal to a sensory organ of the subject, EEG electrodes (4, 6, 8, 10) for deriving an EEG signal from the subject and discriminating means (18) for obtaining the magnitude, or magnitude and phase of the respective components of the EEG signal which have the same frequencies as said plurality of predetermined frequency components.
Claim 26
Dependent Claim
88 words
Apparatus for testing consciousness of a subject, said apparatus comprising generator means (14) for generating a stimulus signal having a plurality of predetermined frequency components simultaneously therein, coupling means (16) for coupling the stimulus signal to a sensory organ of the subject, EEG electrodes (4, 6, 8, 10) for deriving an EEG signal from the subject and discriminating means (18) for obtaining the magnitude, or magnitude and phase of the respective components of the EEG signal which have the same frequencies as said plurality of predetermined frequency components.
Claim 27
Dependent Claim
22 words
Apparatus as claimed in claim 22 wherein said plurality of frequency components have frequencies selected from the range 38 to 72 Hz.
Claim 28
Dependent Claim
53 words
Apparatus as claimed in claim 22 wherein the discriminating means includes a plurality of multiplier circuits (148-158) for separately multiplying the EEG signal by the sine and cosine of each frequency component f n of the stimulus signal, and a plurality of integrator circuits (160-170) for integrating the outputs of the multiplier circuits.
Claim 29
Dependent Claim
49 words
Apparatus as claimed in claim 24 wherein the outputs of the integrator circuits are coupled to inputs of respective sample and hold circuits (172-182) which hold the output values of the integrator circuits at the end of each period of the frequency component f n of the stimulus signal.
Claim 30
Dependent Claim
83 words
Apparatus as claimed in claim 25 wherein the outputs of the sample and hold circuits are averaged over a preselected number of cycles to obtain average values of sine and cosine integrals at each frequency component and wherein the discriminating means includes an arithmetic unit (12) for calculating the magnitude M n of the EEG signal at frequency f n by taking the square root of the sum of the squares of the respective average values at each frequency component f n .
Claim 31
Dependent Claim
46 words
Apparatus as claimed in claim 26 including a multiplexer (186) and an analogue to digital converter (184) and wherein the outputs of the sample and hold circuits are coupled to the converter via the multiplexer and wherein said arithmetic unit performs its operations in digital form.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-25 | 1993-03-27 | 1993-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-25 | 1997-03-27 | 1997-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-25 | 2001-03-27 | 2001-09-26 | $7700.00 | Window Closed / Lapsed |