US4868331A
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Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, processes for their preparation and their use as medicaments
Assignee: Bayer AG
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Filing: 1987-06-29
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Granted: 1989-09-19
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Expires: 2007-06-29
Abstract
Abstract Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R 1 is ##STR2## or SO 2 R 4 , R 3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R 4 is aryl or substituted aryl, R 2 is OH, alkoxy, phenoxy, benzoxy or NR 5 R 6 , and R 5 and R 6 each independently is hydrogen or alkyl, or one of the radicals R 5 or R 6 is benzyl, and physiologically acceptable salts thereof with mono- and divalent cations.
Inventors
- 👤 Ulrich Niewohner
- 👤 Franz-Peter Hoever
- 👤 Bodo Junge
- 👤 Elisabeth Perzborn
- 👤 Friedel Seuter
- 👤 Volker-Bernd Fiedler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:19
CPC Classifications
C; C07; C07C; C07C217/00; C07C217/54; C07C217/64; C07C217/66; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82; C07C213/00; C07C213/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
104 words
An amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acid of the formula ##STR53## in which R 4 is phenyl or naphthyl which optionally carries 1, 2 or 3 substitutents independently selected from the group consisting of halogen, cyano, trifluoromethyl and alkyl with 1 to 4 C atoms, R 2 is hydroxyl, phenoxy, benzoxy or alkoxy with 1 to 4 carbon atoms, or is NR 5 R 6 , and R 5 and R 6 each independently is hydrogen or alkyl with 1 to 4 carbom atoms, or one of the radicals R 5 or R 6 is benzyl, or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 2
Dependent Claim
104 words
An amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acid of the formula ##STR53## in which R 4 is phenyl or naphthyl which optionally carries 1, 2 or 3 substitutents independently selected from the group consisting of halogen, cyano, trifluoromethyl and alkyl with 1 to 4 C atoms, R 2 is hydroxyl, phenoxy, benzoxy or alkoxy with 1 to 4 carbon atoms, or is NR 5 R 6 , and R 5 and R 6 each independently is hydrogen or alkyl with 1 to 4 carbom atoms, or one of the radicals R 5 or R 6 is benzyl, or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 3
Dependent Claim
15 words
A compound or salt according to claim 1, in which halogen is fluorine or chlorine.
Claim 4
Dependent Claim
28 words
A compound according to claim 1, wherein such compound is 6-benzenesulphonylamino-5,6,7,8-tetrahydronaphth-1-yl-oxyacetic acid of the formula ##STR54## or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 5
Dependent Claim
28 words
A compound according to claim 1, wherein such compound is 6-(4-chlorobenzenesulphonylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid of the formula ##STR55## or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 6
Dependent Claim
28 words
A compound according to claim 1, wherein such compound is 6-benzenesulphonylamino-5,6,7,8-tetrahydronaphth-2-yl-oxyacetic acid of the formula ##STR56## or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 7
Dependent Claim
28 words
A compound according to claim 1, wherein such compound is 5-(4-chlorobenzenesulphonylamino-5,6,7,8-tetrahydro-naphth-2-yl-oxyacetic acid of the formula ##STR57## or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 8
Dependent Claim
28 words
A compound according to claim 1, wherein such compound is 5-(4-chlorobenzenesulphonylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid of the formula ##STR58## or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 9
Dependent Claim
28 words
A compound according to claim 1 wherein such compound is 5-(4-Fluorobenzenesulphonylamino)-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid of the formula ##STR59## or a physiologically acceptable salt thereof with a mono- or divalent cation.
Claim 10
Dependent Claim
27 words
A composition for inhibiting aggregation of blood platelets comprising an amount effective therefor of a compound or salt according to claim 1 and a pharmacologically acceptable diluent.
Claim 11
Dependent Claim
19 words
A unit dose of a composition according to claim 8 in the form of a tablet, capsule or ampule.
Claim 12
Dependent Claim
34 words
A method of inhibiting aggregation of blood platelets in a patient in need thereof which comprises administering to such patient an amount effective therefor of a compound or salt thereof according to claim 1.
Claim 13
Dependent Claim
33 words
The method according to claim 11, wherein such compound is 6-benzenesulphonylamino-5,6,7,8-tetrahydronaphth-1-yl-oxyacetic, 6-(4-chlorobenzenesulphonylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid, 6-benzenesulphonylamino-5,6,7,8-tetrahydronaphth-2-yl-oxyacetic, 5-(4-chlorobenzenesulphonylamino-5,6,7,8-tetrahydro-naphth-2-yl-oxyacetic acid or 5-(4-chlorobenzenesulphonylamino-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid, 5-(4-fluorobenzenesulphonylamino)-5,6,7,8-tetrahydro-naphth-1-yl-oxyacetic acid, or a physiologically acceptable salt thereof with a mono- or divalent cation.
References Cited (Backward Citations)
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