US4868187A
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Anti-viral N-substituted pyrimidines
Assignee: Syntex USA LLC
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Filing: 1987-03-09
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Granted: 1989-09-19
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Expires: 2007-03-09
Abstract
Abstract Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, have been shown to exhibit anti-viral and other biological acivities at non-toxic levels.
Inventors
- 👤 Kelvin K. Ogilvie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:22
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/47; C07D239/52; C07D239/54; C07D239/545; C07D239/553; C07D251/00; C07D251/02; C07D251/12; C07D251/14; C07D251/16; C07D473/00; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07F9/00; C07F9/02; C07F9/547; C07F9/645; C07F9/6509; C07F9/6512; C07F9/6561; C07F9/65616; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
33 words
N-substituted pyrimidine compounds corresponding to the formula: ##STR12## wherein X represents a uracil group, a 5-fluorouracil group, or a cytosine group; and R and R' are independently selected from hydrogen, benzyl and tert-butyldimethylsilyl.
Claim 2
Dependent Claim
33 words
N-substituted pyrimidine compounds corresponding to the formula: ##STR12## wherein X represents a uracil group, a 5-fluorouracil group, or a cytosine group; and R and R' are independently selected from hydrogen, benzyl and tert-butyldimethylsilyl.
Claim 3
Dependent Claim
14 words
Compounds according to claim 1, wherein X represents a pyrimidine moiety of formula ##STR13##
Claim 4
Dependent Claim
9 words
A compound according to claim 2, which is 1-[[2-benzyloxy-1-(benzyloxymethyl)ethoxy]methyl]-5-fluorouracil.
Claim 5
Dependent Claim
9 words
A compound according to claim 2, which is 5-Fluoro-1-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-uracil.
Claim 6
Dependent Claim
14 words
Compounds according to claim 1 wherein X represents a pyrimidine moiety of formula ##STR14##
Claim 7
Dependent Claim
9 words
A compound according to claim 5 which is 1-[[2-benzyloxy-1-(benzyloxymethyl)]ethoxymethyl]cytosine.
Claim 8
Dependent Claim
48 words
A pharmaceutical composition suitable for administration to a mammal for treatment of viral infections, selected from the group consisting of herpes virus, influenza virus, and vesicular stomatitis virus, comprising as active ingredient 0.1 to 100 mg per kg of body weight, of a compound according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-09-18 | 1993-03-20 | 1993-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-18 | 1997-03-20 | 1997-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-18 | 2001-03-20 | 2001-09-19 | $7700.00 | Window Closed / Lapsed |