US4868114A
Expired / Lapsed
US
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Method for elevating glutathione levels
Assignee: Bioceuticals Inc
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Filing: 1989-01-13
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Granted: 1989-09-19
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Expires: 2009-01-13
Abstract
Abstract A method comprising stimulating the biosynthesis of glutathione in mammalian cells by contacting the cells with an effective amount of a compound of the formula: <IMAGE> wherein R is a (CHOH)nCH2OH and wherein n is 1-5, preferably R is derived from a D-aldose monosaccharide.
Inventors
- 👤 Herbert T. Nagasawa
- 👤 Jeanette C. Roberts
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; A61K31/33; A61K31/395; A61K31/41; A61K31/425; C; C07; C07H; C07H9/00; C07H9/06; C12; C12N; C12N1/00; C12N1/38
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
46 words
A method comprising stimulating the biosynthesis of glutathione in mammalian cells by contacting the cells with an effective amount of a compound of the formula: ##STR12## wherein R is a (CHOH) n CH 2 OH and wherein n is 1-5, and the pharmaceutically acceptable salts thereof.
Claim 2
Independent Claim
46 words
A method comprising stimulating the biosynthesis of glutathione in mammalian cells by contacting the cells with an effective amount of a compound of the formula: ##STR12## wherein R is a (CHOH) n CH 2 OH and wherein n is 1-5, and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the cells are liver cells.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein R is derived from a D-aldose monosaccharide.
Claim 5
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 5 residue of D-arabinose.
Claim 6
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 5 residue of D-lyxose.
Claim 7
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 5 residue of D-ribose.
Claim 8
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 5 residue of D-xylose.
Claim 9
Dependent Claim
17 words
The method of claim 3 wherein R is the C 2 -C 6 residue due of D-galactose.
Claim 10
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 6 residue of D-glucose.
Claim 11
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 6 residue of D-mannose.
Claim 12
Dependent Claim
16 words
The method of claim 3 wherein R is the C 2 -C 3 residue of D-glyceraldehyde.
Claim 13
Dependent Claim
17 words
The method of claim 1 wherein the compound is administered to a mammal parenterally in aqueous solution.
Claim 14
Dependent Claim
11 words
The method of claim 12 wherein the compound is administered intravenously.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-18 | 1993-03-20 | 1993-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-18 | 1997-03-20 | 1997-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-18 | 2001-03-20 | 2001-09-19 | $7700.00 | Window Closed / Lapsed |