US4866084A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Topsentin compounds effective against viruses and certain tumors
Assignee: Harbor Branch Oceanographic Institute Foundation Inc
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Filing: 1988-12-19
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Granted: 1989-09-12
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Expires: 2008-12-19
Abstract
Abstract A new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing the compounds and methods of using them are disclosed. This new class of compounds has the generic formula: <IMAGE> Wherein X = <IMAGE> +TR <IMAGE> R1-8 are the same or different selected from -H, -OH, halogen, -R, -OR, -OCOR, or -OA; Y is the single group -O, or two groups, same or different, selected from -H, -OH, -OR, or -OCOR with the provision that Y shall not be two -OH groups; Z are the same or different selected from -H, -R; R is C1-5 alkyl and A is -R-phenyl. The compounds are antiviral agents and antitumor agents which are effective against specific tumors.
Inventors
- 👤 Sarath P. Gunasekera
- 👤 Sue S. Cross
- 👤 Yoel Kashman
- 👤 May S. Lui
- 👤 Kenneth L. Rinehart
- 👤 Shinji Tsujii
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:33
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/14
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
62 words
A substantially pure compound of the formula: ##STR6## R 1-8 are the same or different selected from --H, --OH, halogen, --R, --OR, --OCOR, or --OA; Y is the single group O, or two groups, same or different, selected from --H, --OH, --OR, or --OCOR; Z are the same or different selected from --H, --R; R is C1-5 alkyl and A is --R-phenyl.
Claim 2
Dependent Claim
62 words
A substantially pure compound of the formula: ##STR6## R 1-8 are the same or different selected from --H, --OH, halogen, --R, --OR, --OCOR, or --OA; Y is the single group O, or two groups, same or different, selected from --H, --OH, --OR, or --OCOR; Z are the same or different selected from --H, --R; R is C1-5 alkyl and A is --R-phenyl.
Claim 3
Dependent Claim
72 words
A substantially pure compound of the formula: ##STR7## wherein R 2 & R 6 are --H while R 3 & R 7 are --H, --OH, halogen, --R, --OR, --OCOR or --OA; or R 3 & R 7 are --H while R 2 & R 6 are --H, --OH, halogen, --R, --OR, --OCOR or --OA; Z are the same or different selected from --H, --R; R is C1-5 alkyl and A is --R-phenyl.
Claim 4
Dependent Claim
72 words
A substantially pure compound of the formula: ##STR7## wherein R 2 & R 6 are --H while R 3 & R 7 are --H, --OH, halogen, --R, --OR, --OCOR or --OA; or R 3 & R 7 are --H while R 2 & R 6 are --H, --OH, halogen, --R, --OR, --OCOR or --OA; Z are the same or different selected from --H, --R; R is C1-5 alkyl and A is --R-phenyl.
Claim 5
Dependent Claim
113 words
A substantially pure compound of the formula: ##STR8## wherein: 1: R 2 , R 3 , R 6 =H; R 7 =OH 2: R 2 , R 6 =H; R 3 =Br; R 7 =OH 4: R 2 , R 6 , R 7 =H; R 3 =OH, 5: R 2 , R 6 =H; R 3 , R 7 =OH, 6: R 2 , R 3 , R 6 , R 7 =H 7: R 2 , R 3 , R 7 =H; R 6 =OH 8: R 3 , R 6 , R 7 =H; R 2 =OH, 9: R 2 , R 6 =OH; R 3 , R 7 =H.
Claim 6
Dependent Claim
113 words
A substantially pure compound of the formula: ##STR8## wherein: 1: R 2 , R 3 , R 6 =H; R 7 =OH 2: R 2 , R 6 =H; R 3 =Br; R 7 =OH 4: R 2 , R 6 , R 7 =H; R 3 =OH, 5: R 2 , R 6 =H; R 3 , R 7 =OH, 6: R 2 , R 3 , R 6 , R 7 =H 7: R 2 , R 3 , R 7 =H; R 6 =OH 8: R 3 , R 6 , R 7 =H; R 2 =OH, 9: R 2 , R 6 =OH; R 3 , R 7 =H.
Claim 7
Dependent Claim
17 words
A compound of claim 1 according to the formula: ##STR9## wherein R 3 is hydrogen or bromine.
Claim 8
Dependent Claim
40 words
A pharmaceutical composition comprising between about 0.1% and 45% by weight, based on the total weight of said composition, as an active ingredient one or more of the compounds of claim 1 and a non-toxic pharmaceutically acceptable carrier or diluent.
Claim 9
Dependent Claim
40 words
A pharmaceutical composition comprising between about 0.1% and 45% by weight, based on the total weight of said composition, as an active ingredient one or more of the compounds of claim 2 and a non-toxic pharmaceutically acceptable carrier or diluent.
Claim 10
Dependent Claim
40 words
A pharmaceutical composition comprising between about 0.1% and 45% by weight, based on the total weight of said composition, as an active ingredient one or more of the compounds of claim 3 and a non-toxic pharmaceutically acceptable carrier or diluent.
Claim 11
Dependent Claim
40 words
A pharmaceutical composition comprising between about 0.1% and 45% by weight, based on the total weight of said composition, as an active ingredient one or more of the compounds of claim 4 and a non-toxic pharmaceutically acceptable carrier or diluent.
References Cited (Backward Citations)
US4217357A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |