US4865845A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Release rate adjustment of osmotic or diffusional delivery devices
Assignee: Alza Corp
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Filing: 1987-08-28
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Granted: 1989-09-12
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Expires: 2007-08-28
Abstract
Abstract A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictable alteration in delivery rate. Among other attachment means, a water soluble adhesive maintains the structure on the delivery device.
Inventors
- 👤 James B. Eckenhoff
- 👤 John Urquhart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
107 words
A device for increasing and delivering duration of an osmotic or diffusional delivery device of a predetermined configuration, said delivery device having an external surface which acts as a transport area through which fluid passes to activate said delivery device, comprising: a preformed integral sleeve impermeable to the passage of fluid, having a configuration substantially similar to said external surface and adapted to cover a portion of said surface; whereby osmotic or diffusional fluid is prevented from contacting the covered portion; and a means for precisely controlling the portion of transport area covered by said sleeve comprising markings on said sleeve having at least one weakened zone.
Claim 2
Independent Claim
107 words
A device for increasing and delivering duration of an osmotic or diffusional delivery device of a predetermined configuration, said delivery device having an external surface which acts as a transport area through which fluid passes to activate said delivery device, comprising: a preformed integral sleeve impermeable to the passage of fluid, having a configuration substantially similar to said external surface and adapted to cover a portion of said surface; whereby osmotic or diffusional fluid is prevented from contacting the covered portion; and a means for precisely controlling the portion of transport area covered by said sleeve comprising markings on said sleeve having at least one weakened zone.
Claim 3
Dependent Claim
17 words
The device of claim 1 which further comprises: a means for adjusting the size of said sleeve.
Claim 4
Dependent Claim
20 words
The device of claim 2 wherein said means for adjusting comprises at least one score line disposed about said sleeve.
Claim 5
Dependent Claim
29 words
The device of claim 1 wherein said sleeve comprises a plurality of weakened zones each having a predetermined relationship to the delivering duration of said osmotic or diffusional device.
Claim 6
Dependent Claim
18 words
The device of claim 1 which further comprises: a means for attaching said sleeve to the delivery device.
Claim 7
Dependent Claim
15 words
The device of claim 5 wherein said means for attaching comprises a fluid permeable adhesive.
Claim 8
Dependent Claim
11 words
The device of claim 6 wherein said adhesive contains an ester.
Claim 9
Dependent Claim
18 words
The device of claim 6 wherein said adhesive is at least as fluid permeable as the transport area.
Claim 10
Dependent Claim
11 words
The device of claim 7 wherein said adhesive contains cellulose ester.
Claim 11
Dependent Claim
18 words
The device of claim 1 wherein said sleeve has the form of a cylinder, closed at one end.
Claim 12
Dependent Claim
21 words
The device of claim 1 wherein said sleeve is formed from polymethylmethacrylate, which is impermeable to said osmotic or diffusional fluid.
Claim 13
Dependent Claim
25 words
The device of claim 1 wherein said sleeve is formed from a styrene butadiene block copolymer, which is impermeable to said osmotic or diffusional fluid.
Claim 14
Dependent Claim
21 words
The device of claim 1 wherein said sleeve is formed from polysulfone, which is impermeable to said osmotic or diffusional fluid.
Claim 15
Dependent Claim
21 words
The device of claim 1 wherein said sleeve is formed from polycarbonate, which is impermeable to said osmotic or diffusional fluid.
Claim 16
Dependent Claim
21 words
The device of claim 1 wherein said sleeve is formed from polyethylene, which is impermeable to said osmotic or diffusional fluid.
Claim 17
Independent Claim
111 words
A method of prolonging the delivering rate of diffusional or osmotic delivery devices of a predetermined configuration having an external surface which acts as a transport area through which fluid passes to activate said device, for a predetermined length of time, comprising the steps of: forming a sleeve impermeable to the passage of fluid, sized to cover a portion of the transport area and having at least one weakened zone; removing a portion of the sleeve at said weakened zone; inserting the delivery device into the sleeve; and attaching the sleeve to the delivery device; wherein the assemblage thus formed is exposed to the osmotic or diffusional fluid to commence delivering.
Claim 18
Independent Claim
111 words
A method of prolonging the delivering rate of diffusional or osmotic delivery devices of a predetermined configuration having an external surface which acts as a transport area through which fluid passes to activate said device, for a predetermined length of time, comprising the steps of: forming a sleeve impermeable to the passage of fluid, sized to cover a portion of the transport area and having at least one weakened zone; removing a portion of the sleeve at said weakened zone; inserting the delivery device into the sleeve; and attaching the sleeve to the delivery device; wherein the assemblage thus formed is exposed to the osmotic or diffusional fluid to commence delivering.
Claim 19
Dependent Claim
36 words
The method of claim 16 wherein said forming step further comprises: forming a sleeve comprised of a plurality of weakened zones each having a predetermined relationship to the delivering duration of said osmotic or diffusional device.
Claim 20
Dependent Claim
23 words
The method of claim 16 wherein said attaching step further comprises: disposing a measured amount of a fluid permeable adhesive in the sleeve.
Claim 21
Dependent Claim
24 words
The method of claim 16 wherein said attaching step further comprises: disposing a measured amount of a fluid permeable adhesive on the transport area.
Claim 22
Dependent Claim
26 words
The method of claim 16 which further comprises the steps of: inserting a supporting mandrel into the sleeve; and cutting the sleeve along the weakened zone.
Claim 23
Dependent Claim
21 words
The method of claim 16 which further comprises the step of: marking the sleeve to determine at least two separate portions.
Claim 24
Dependent Claim
26 words
The method of claim 21 which further comprises the steps of: inserting a supporting mandrel into the sleeve; and cutting the sleeve along the marked zone.
References Cited (Backward Citations)
US3993073A
Cited
US3995631A
Cited
US3760984A
Cited
US3845770A
Cited
US3916899A
Cited
US3993058A
Cited
US3987790A
Cited
US4016880B1
Cited
US4016880A
Cited
US4111202A
Cited
US4111203A
Cited
US4203442A
Cited
US4203440A
Cited
US4210139A
Cited
US4304232A
Cited
US4320758A
Cited
US4300558A
Cited
US4350271A
Cited
US4327725A
Cited
US4367741A
Cited
US4474575A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |