US4865581A
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US
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Retroperfusion control apparatus, system and method
Assignee: Alsius Corp
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Filing: 1987-05-29
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Granted: 1989-09-12
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Expires: 2007-05-29
Abstract
Abstract Retroperfusion control apparatus for supplying arterial blood of a patient to the venous side of the patient's heart including a pump having an inlet and an outlet and a piston movable through a pump stroke for moving a liquid from the inlet to the outlet of the pump. A stepper motor is provided which drives the piston. Electronic circuitry is provided for driving the stepper motor and senses the presence of an R wave in a patient to operate the stepper motor in response to the sensed R wave.
Inventors
- 👤 Ingemar H. Lundquist
- 👤 Zoltan Tarczy-Hornoch
- 👤 Thomas J. Kardos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:23
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3613; A61M1/3621; A61M1/3622; A61M1/36224; A61M1/36225; A61M1/36226; A61M1/3643; A61M1/3644; A61M60/00; A61M60/10; A61M60/122; A61M60/126; A61M60/13; A61M60/40; A61M60/403; A61M60/408; A61M60/50; A61M60/508; A61M60/515; A61M60/538; A61M1/362265; A61M25/00; A61M2025/0001; A61M2025/0002; A61M25/10; A61M25/1018; A61M2025/102; A61M2025/1022; A61M2205/00; A61M2205/12; A61M2205/128; A61M2205/14; A61M2205/33; A61M2205/3303; A61M2205/3331; A61M2205/3344; A61M2205/3355; A61M2230/00; A61M2230/04; A61M60/104; A61M60/109; A61M60/113
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
140 words
In a control apparatus for supplying arterial blood of a patient to the venous side of the patient's heart, a pump having an inlet adapted to be coupled to an artery of the patient and an outlet, a catheter coupled to the outlet and adapted to be connected to a vein of the patient, the catheter having an inflatable balloon mounted thereon, movable means forming a part of the pump movable through a pump stroke for moving a liquid from the inlet to the outlet of the pump, a stepper motor, means coupling the stepper motor to the movable means, and electronic circuitry for driving the stepper motor, the electronic circuitry including means for sensing the presence of an R wave in an electrocardiogram of a patient and for operating the stepper motor in response to the sensed R wave.
Claim 2
Dependent Claim
140 words
In a control apparatus for supplying arterial blood of a patient to the venous side of the patient's heart, a pump having an inlet adapted to be coupled to an artery of the patient and an outlet, a catheter coupled to the outlet and adapted to be connected to a vein of the patient, the catheter having an inflatable balloon mounted thereon, movable means forming a part of the pump movable through a pump stroke for moving a liquid from the inlet to the outlet of the pump, a stepper motor, means coupling the stepper motor to the movable means, and electronic circuitry for driving the stepper motor, the electronic circuitry including means for sensing the presence of an R wave in an electrocardiogram of a patient and for operating the stepper motor in response to the sensed R wave.
Claim 3
Dependent Claim
18 words
Apparatus as in claim 1 wherein the pump is in the form of a removable disposable pump cassette.
Claim 4
Dependent Claim
54 words
Apparatus as in claim 2 wherein the movable means is a piston mounted for reciprocatory movement in the pump cassette in upstroke and downstroke directions and wherein the stepper motor is rotated in one direction during the upstroke direction and wherein the stepper motor is operated in a reverse direction during the downstroke direction.
Claim 5
Dependent Claim
22 words
Apparatus as in claim 1 wherein said electronic circuitry includes a microprocessor for generating digital output signals for operating the stepper motor.
Claim 6
Dependent Claim
69 words
Apparatus as in claim 4 together with a bubble chamber coupled to the pump for receiving arterial blood and wherein said electronic circuitry includes detecting means associated with the bubble chamber and connected to the microprocessor for informing the microprocessor when bubbles of air appear in the arterial blood supply and also when the amount of arterial blood drops below a predetermined level to stop operation of the pump.
Claim 7
Dependent Claim
92 words
Apparatus as in claim 4 together with a pump console, wherein the stepper motor is mounted in the pump console and wherein the means coupling the stepper motor in the movable means is also in the pump console and electrical means carried by the pump console and adapted to be engaged by the pump for ascertaining when the pump is in a proper position and for supplying an electrical signal to the microprocessor when the pump is improperly positioned in the pump console to cause the microprocessor to initiate an alarm condition.
Claim 8
Dependent Claim
28 words
Apparatus as in claim 4 together with means coupled to the microprocessor for cutting off arterial blood flow through the pump when movement of the movable means ceases.
Claim 9
Dependent Claim
49 words
Apparatus as in claim 7 wherein said means for cutting off arterial blood flow includes a pinch-off valve mounted on the pump console for controlling the flow of arterial blood through the pump and means connecting the pinch-off valve to the microprocessor for controlling operation of the pinch-off valve.
Claim 10
Dependent Claim
37 words
Apparatus as in claim 4 together with means for sensing the position of the stepper motor connected to the microprocessor for supplying information to the microprocessor as to the location of the movable means of the pump.
Claim 11
Dependent Claim
114 words
Apparatus as in claim 4 wherein the microprocessor is programmable and has been programmed to start the pump stroke at approximately 45% of the R wave to R wave interval and terminates at approximately 95% of the R wave to R wave interval and wherein the digital output signals to the stepper motor for the upstroke are supplied during an initial portion of the time period for the upstroke so that a pause is provided at the upper extremity of the pump stroke and prior to the downstroke so as to permit any pressure buildup in the pump to dissipate and to permit a continued flow of blood to occur prior to the downstroke.
Claim 12
Dependent Claim
31 words
Apparatus as in claim 10 wherein the microprocessor has been programmed so that approximately one half of the time allotted for the upstroke is allotted for the pause after the upstroke.
Claim 13
Dependent Claim
33 words
Apparatus as in claim 4 wherein said electronic circuitry includes means to cause a predetermined mean flow to be supplied to the patient which is independent of the heart rate of the patient.
Claim 14
Dependent Claim
20 words
Apparatus as in claim 12 wherein said means to cause a predetermined mean flow includes a program in the microprocessor.
Claim 15
Dependent Claim
71 words
Apparatus as in claim 4 together with an external ECG monitor adapted to be coupled to the patient and supplying an R trigger circuit signal and wherein the microprocessor includes means for creating a pattern from the R trigger circuit signal and means for comparing the signal received from the external ECG monitor with the pattern for ascertaining whether the R trigger circuit signal received is appropriate for operating the pump.
Claim 16
Dependent Claim
28 words
Apparatus as in claim 4 together with display means coupled to the microprocessor for displaying an electrocardiogram, the R wave and the pump stroke in a timed relationship.
Claim 17
Dependent Claim
27 words
Apparatus as in claim 4 wherein said electronic circuitry includes detecting means connected to the microprocessor for informing the microprocessor of the arterial pressure of the patient.
Claim 18
Dependent Claim
31 words
Apparatus as in claim 16 wherein said detecting means for detecting arterial pressure is used to detect the presence of diastole in a patient independently from the electrocardiogram R wave signal.
Claim 19
Dependent Claim
27 words
Apparatus as in claim 4 wherein said electronic circuitry includes detecting means connected to the microprocessor for supplying coronary sinus pressure of the patient to the microprocessor.
Claim 20
Independent Claim
113 words
A method for supplying arterial blood into a venous region of the heart, comprising taking an electrocardiogram of the patient, ascertaining when an R wave is present in the electrocardiogram, supplying arterial blood from the patient under positive pressure into a venous region of the heart for a predetermined period of time in accordance with the R wave of the patient, providing a pause period for a predetermined period of time to permit any positive pressure created to be dissipated and to permit continued flow to occur and thereafter allowing antegrade flow of venous blood from the heart for a predetermined period of time in accordance with the R wave of the patient.
Claim 21
Independent Claim
113 words
A method for supplying arterial blood into a venous region of the heart, comprising taking an electrocardiogram of the patient, ascertaining when an R wave is present in the electrocardiogram, supplying arterial blood from the patient under positive pressure into a venous region of the heart for a predetermined period of time in accordance with the R wave of the patient, providing a pause period for a predetermined period of time to permit any positive pressure created to be dissipated and to permit continued flow to occur and thereafter allowing antegrade flow of venous blood from the heart for a predetermined period of time in accordance with the R wave of the patient.
Claim 22
Dependent Claim
27 words
A method as in claim 19 wherein the pause period is made substantially equal to the period during which arterial blood is being introduced under positive pressure.
Claim 23
Dependent Claim
44 words
A method as in claim 20 wherein the time for antegrade flow of arterial blood is made to be substantially equal to the period of time in which arterial blood is supplied retrograde under positive pressure and the period during which the pause occurs.
Claim 24
Dependent Claim
42 words
A method as in claim 19 together with the steps of sensing any change in heart rate and making adjustments in the arterial blood supplied so that arterial blood is supplied to the patient at a substantially constant mean blood flow rate.
Claim 25
Dependent Claim
56 words
A method as in claim 19 together with the step of independently generating an R-wave pattern, comparing the R wave from the electrocardiogram with an independently generated R wave pattern to ascertain whether on R wave has been received from the patient which is appropriate for supplying arterial blood into a venous region of the heart.
Claim 26
Dependent Claim
30 words
A method as in claim 19 together with the step of detecting bubbles of air in the arterial blood supply, cutting off the arterial blood flow, and initiating an alarm.
Claim 27
Dependent Claim
36 words
A method as in claim 19 together with the step of collecting arterial blood in a reservoir, detecting when the level of arterial blood in the reservoir drops below a predetermined level and initiating an alarm.
Claim 28
Dependent Claim
18 words
A method as in claim 19 to initiate an alarm if the heart rate exceeds a predetermined value.
Claim 29
Dependent Claim
19 words
A method as in claim 19 to initiate an alarm if the heart rate drops below a predetermined value.
Claim 30
Dependent Claim
52 words
A method as in claim 19 for use with a pump having a movable means for pumping arterial blood together with the step of sensing the location of the movable means in the pump to initiate an alarm if the location of the movable means does not change in a predetermined manner.
Claim 31
Dependent Claim
54 words
A method as in claim 28 together with the step of determining whether an R wave of the patient is appropriate for operation of the movable means, and whether aborting continued movement of the movable means during the R wave of the patient is deemed to be inappropriate for operation of the movable means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-09-11 | 1993-03-13 | 1993-09-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-09-11 | 1997-03-13 | 1997-09-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-09-11 | 2001-03-13 | 2001-09-12 | $7700.00 | Window Closed / Lapsed |