Intestine drug delivery

Claim 2

An oral delivery system for delivering a beneficial drug to the intetine of a gastrointestinal tract of a warm-blooded animal, the delivery system comprising: (a) means for shielding a multiplicity of reservoirs from the stomach of the gastrointestinal tract, said means a matrix comprising an innocuous polymeric composition comprising a member selected from the group consisting of an alkali salt of cellulose acetate phthalate, and a salt of hydroxypropylmethylcellulose phthalate, that substantially maintains its physical and chemical integrity in the stomach; (b) a multiplicity of reservoirs in matrix, the reservoirs comprising: (1) a beneficial intestinal administrable drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine, said composition comprising a cellulosic polymer; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters the intestine the matrix releases the multiplicity of reservoirs in response to the intestine and delivers the beneficial drug in the intestine over a prolonged period of time.

Claim 3

An oral delivery system for delivering a beneficial drug, the delivery system comprising: (a) a matrix comprising an innocuous polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said polymeric composition a member selected from the group consisting of a cellulose carboxylic acid phthalate and a cellulose ethyl phthalate; (b) a multiplicity of reservoirs in the matrix, the reservoirs comprising: (1) a beneficial drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine of a gastrointestinal tract, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic, and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters the intestine, the matrix of the delivery system releases the multiplicity of reservoirs in response to the intestine in which intestine the reservoirs deliver the beneficial drug over a prolonged period of time.

Claim 4

An oral delivery system for delivering a beneficial drug, the delivery system comprising: (a) a matrix comprising an innocuous polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said polymeric composition a member selected from the group consisting of a cellulose carboxylic acid phthalate and a cellulose ethyl phthalate; (b) a multiplicity of reservoirs in the matrix, the reservoirs comprising: (1) a beneficial drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine of a gastrointestinal tract, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic, and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters the intestine, the matrix of the delivery system releases the multiplicity of reservoirs in response to the intestine in which intestine the reservoirs deliver the beneficial drug over a prolonged period of time.

Claim 5

An oral delivery system for delivering a beneficial drug, the delivery system comprising: (a) a matrix comprising an innocuous polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said composition a member selected from the group consisting of starch acetate phthalate and amylose acetate phthalate; (b) a multiplicity of reservoirs in the matrix, the reservoirs comprising: (1) a beneficial drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic, and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and its chemical integrity, and when the delivery system enters the intestine, the matrix of the delivery system releases the multiplicity of reservoirs in response to the intestine wherein the reservoirs deliver the beneficial drug over a prolonged period of time.

Claim 6

An oral delivery system for delivering a beneficial drug, the delivery system comprising: (a) a matrix comprising an innocuous polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said composition a member selected from the group consisting of starch acetate phthalate and amylose acetate phthalate; (b) a multiplicity of reservoirs in the matrix, the reservoirs comprising: (1) a beneficial drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic, and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and its chemical integrity, and when the delivery system enters the intestine, the matrix of the delivery system releases the multiplicity of reservoirs in response to the intestine wherein the reservoirs deliver the beneficial drug over a prolonged period of time.

Claim 7

An oral delivery system for delivering a beneficial drug to the intestine, the delivery system comprising: (a) a matrix shaped and sized for oral admittance into the gastrointestinal tract, which matrix comprises a polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said composition a member selected from the group consisting of an alkali salt of cellulose acetate phthalate and an alkaline earth salt of cellulose acetate phthalate; (b) a plurality of tiny reservoirs dispersed in the matrix, the reservoirs comprising: (1) a beneficial intestinal administrable drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the benefical drug in the intestine, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic, and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters intestine, the matrix of the delivery system releases the plurality of reservoirs in response to the intestine and delivers the drug to the intestine over a prolonged period of time.

Claim 8

An oral delivery system for delivering a beneficial drug to the intestine, the delivery system comprising: (a) a matrix shaped and sized for oral admittance into the gastrointestinal tract, which matrix comprises a polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said composition a member selected from the group consisting of an alkali salt of cellulose acetate phthalate and an alkaline earth salt of cellulose acetate phthalate; (b) a plurality of tiny reservoirs dispersed in the matrix, the reservoirs comprising: (1) a beneficial intestinal administrable drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the benefical drug in the intestine, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic, and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters intestine, the matrix of the delivery system releases the plurality of reservoirs in response to the intestine and delivers the drug to the intestine over a prolonged period of time.

Claim 9

An oral delivery system for delivering a beneficial drug to the intestine of a warm-blooded animal, the delivery system comprising: (a) a matrix adapted and shaped for oral admittance into the gastrointestinal tract, the matrix comprising an innocuous polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said composition a member selected from the group consisting of cellulose acetate hexahydrophthalate and hydroxypropylmethylcellulose hexahydrophthalate; (b) a plurality of reservoirs housed in the matrix, the reservoirs comprising: (1) a beneficial intestinal administrable drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters the intestine, the matrix releases the plurality of reservoirs in response to the intestine and thereby delivers the drug to the intestine over a prolonged period of time.

Claim 10

An oral delivery system for delivering a beneficial drug to the intestine of a warm-blooded animal, the delivery system comprising: (a) a matrix adapted and shaped for oral admittance into the gastrointestinal tract, the matrix comprising an innocuous polymeric composition that substantially maintains its physical and chemical integrity in the stomach, said composition a member selected from the group consisting of cellulose acetate hexahydrophthalate and hydroxypropylmethylcellulose hexahydrophthalate; (b) a plurality of reservoirs housed in the matrix, the reservoirs comprising: (1) a beneficial intestinal administrable drug; (2) a wall that surrounds the beneficial drug, which wall comprises an innocuous composition that releases the beneficial drug in the intestine, said wall comprising a member selected from the group consisting of a fatty ester mixed with a wax, a cellulose ester, a cellulose ether, a polyester, a polylactic, a polyglycolic and a polyorthoester; and, (c) wherein, when the delivery system is in operation in the stomach, the delivery system maintains its physical and chemical integrity, and when the delivery system enters the intestine, the matrix releases the plurality of reservoirs in response to the intestine and thereby delivers the drug to the intestine over a prolonged period of time.