US4853377A
Expired / Lapsed
US
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Method and composition for increasing production of serotonin
Assignee: Individual
•
Filing: 1988-02-29
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Granted: 1989-08-01
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Expires: 2008-02-29
Abstract
Abstract The production of the neurotransmitter serotonin is increased through administration of a therapeutic composition which includes L-tryptophan in combination with a salicylate, an ascorbate, calcium, magnesium, copper, pyridoxine, niacin and a carbohydrate such as fructose. Both the absolute free fraction and the relative amount of the albumin-bound fraction of serum L-tryptophan are increased so that transport of L-tryptophan from the blood plasma across the blood-brain barrier into the brain is increased. Once within the brain, L-tryptophan is converted to serotonin.
Inventors
- 👤 Robert L. Pollack
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/7004; A61K31/60
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
93 words
A method for treating physiological disorders responsive to treatment with L-tryptophan, wherein said method comprises: administering to a patient a dosage of a composition comprising L-tryptophan in an amount sufficient to increase transport of L-tryptophan into the patient's brain and a salicylate selected from the group consisting of sodium salicylate, choline salicylate and magnesium salicylate in an amount sufficient to release L-tryptophan from the patient's serium albumin, said dosage of the composition being sufficient to increase production of serotonin within the patient's brain to a level which provides relief of said physiological disorders.
Claim 2
Independent Claim
93 words
A method for treating physiological disorders responsive to treatment with L-tryptophan, wherein said method comprises: administering to a patient a dosage of a composition comprising L-tryptophan in an amount sufficient to increase transport of L-tryptophan into the patient's brain and a salicylate selected from the group consisting of sodium salicylate, choline salicylate and magnesium salicylate in an amount sufficient to release L-tryptophan from the patient's serium albumin, said dosage of the composition being sufficient to increase production of serotonin within the patient's brain to a level which provides relief of said physiological disorders.
Claim 3
Dependent Claim
17 words
The method of claim 1, which further comprises administering to the patient a dosage of a carbohydrate.
Claim 4
Dependent Claim
51 words
The method of claim 1, which further comprises administering to the patient a dosage of a carbohydrate, a dosage of a calcium supplement, a dosage of a magnesium supplement, a dosage of an ascorbate, a dosage of a copper supplement, a dosage of a niacin supplement and a dosage of pyridoxine.
Claim 5
Dependent Claim
86 words
A composition for increasing production of serotonin within a patient's brain, comprising a dosage of L-tryptophan in an amount sufficient to increase transport of L-tryptophan into the patient's brain, and a dosage of a pharmaceutically acceptable salicylate, selected from the group consisting of sodium salicylate, choline salicylate and magnesium salicylate said dosage of said salicylate being sufficient to release L-tryptophan from the patient's serum albumin, and said dosages combined so as to increase said production of serotonin to a level which provides relief of physiological disorders.
Claim 6
Dependent Claim
86 words
A composition for increasing production of serotonin within a patient's brain, comprising a dosage of L-tryptophan in an amount sufficient to increase transport of L-tryptophan into the patient's brain, and a dosage of a pharmaceutically acceptable salicylate, selected from the group consisting of sodium salicylate, choline salicylate and magnesium salicylate said dosage of said salicylate being sufficient to release L-tryptophan from the patient's serum albumin, and said dosages combined so as to increase said production of serotonin to a level which provides relief of physiological disorders.
Claim 7
Dependent Claim
27 words
The composition of claim 4, further comprising a dosage of a carbohydrate in an amount sufficient to release insulin into the patient's blood for freeing albumin-bound L-tryptophan.
Claim 8
Dependent Claim
20 words
The composition of claim 4, further comprising a dosage of a calcium supplement for facilitating conversion of L-tryptophan into serotonin.
Claim 9
Dependent Claim
19 words
The composition of claim 4, further comprising a dosage of a magnesium supplement for enhancing the neurotransmission of serotonin.
Claim 10
Dependent Claim
21 words
The composition of claim 7, wherein said salicylate and said magnesium supplement are each provided in the form of magnesium salicylate.
Claim 11
Dependent Claim
17 words
The composition of claim 4, further comprising a dosage of ascorbic acid for facilitating hydroxylation of L-tryptophan.
Claim 12
Dependent Claim
27 words
The composition of claim 9, wherein said ascorbic acid is provided as an ascorbate selected from the group consisting of sodium ascorbate, calcium ascorbate and niacinamide ascorbate.
Claim 13
Dependent Claim
20 words
The composition of claim 4, further comprising a dosage of a copper supplement for facilitating conversion of L-tryptophan into serotonin.
Claim 14
Dependent Claim
20 words
The composition of claim 4, futher comprising a dosage of a niacin supplement for preventing synthesis of niacin from L-tryptophan.
Claim 15
Dependent Claim
18 words
The composition of claim 4, further comprising a dosage of pyridoxine for facilitating conversion of L-tryptophan into serotonin.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-31 | 1993-01-30 | 1993-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-31 | 1997-01-30 | 1997-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-31 | 2001-01-30 | 2001-08-01 | $7700.00 | Window Closed / Lapsed |