US4851229A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composition comprising a therapeutic agent and a modulating agent
Assignee: Alza Corp
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Filing: 1988-01-29
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Granted: 1989-07-25
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Expires: 2008-01-29
Abstract
Abstract An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
Inventors
- 👤 Paul R. Magruder
- 👤 Brian Barclay
- 👤 Patrick S. L. Wong
- 👤 Felix Theeuwes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
137 words
A composition useful for producing a pulsed rate of delivery of a therapeutic agent from an osmotic device, said composition comprising a therapeutic agent and a modulating agent that dissolves in aqueous fluid and forms a solution, which modulating agent is a different agent than the therapeutic agent, said modulating agent a member selected from the group of modulating agents consisting of a solid organic acid, an inorganic salt, and an organic salt, said modulating agent present relative to said therapeutic agent in an amount less than the amount needed to maintain saturation in aqueous fluid that enters the osmotic device and wets the composition, thereby letting the concentration of the therapeutic agent increase in the aqueous fluid that enters the osmotic device and produce a pulsed rate of delivery of therapeutic agent from the osmotic device.
Claim 2
Dependent Claim
137 words
A composition useful for producing a pulsed rate of delivery of a therapeutic agent from an osmotic device, said composition comprising a therapeutic agent and a modulating agent that dissolves in aqueous fluid and forms a solution, which modulating agent is a different agent than the therapeutic agent, said modulating agent a member selected from the group of modulating agents consisting of a solid organic acid, an inorganic salt, and an organic salt, said modulating agent present relative to said therapeutic agent in an amount less than the amount needed to maintain saturation in aqueous fluid that enters the osmotic device and wets the composition, thereby letting the concentration of the therapeutic agent increase in the aqueous fluid that enters the osmotic device and produce a pulsed rate of delivery of therapeutic agent from the osmotic device.
Claim 3
Dependent Claim
28 words
The composition useful for producing a pulsed rate of delivery of a therapeutic agent from an osmotic device according to claim 1, wherein the therapeutic agent is salbutamol.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |