Hydrophilic silicone-organic copolymer elastomers

Claim 1

A method of controlling the delivery of a bioactive agent to a substrate, comprising the steps of: (a) contacting the substrate with a membrane formed from a water absorbing, hydrophilic silicone organic elastomer comprising a polymerization product formed from a composition consisting essentially of (A) from 50 to 95 parts by weight of at least one block copolymer of the formula ##STR14## wherein Z is CH 2 ═CR"COOR'"NHCO--, ##STR15## Q is a divalent radical obtained by removing the NCO radicals from a diisocyanate selected from the group consisting of aliphatic, cycloaliphatic and aromatic diisocyanates, T is a divalent radical selected from the group consisting of --NR"-- and --O-- wherein said T is attached to a carbon atom on --C c H 2c -- which is at least the third carbon atom away from the silicon atom to which the --C c H 2c -- radical is attached, a is an integer of from 4 to 49, inclusive, b is an integer of from 0 to 15, inclusive, c is an integer having a value of 3 or 4, d is an integer of from 0 to 25, inclusive, e is an integer of from 5 to 50 inclusive, d+e is no greater than 50 and e is greater than or equal to d, f is 0 or 1, f' is 0 or 1, f+f'+b is at least 2, R is a monovalent hydrocarbon or halohydrocarbon radical of from 1 to 6 inclusive carbon atoms which is free of aliphatic unsaturation, R' is a methyl or a phenyl radical, R" is an alkyl radical of from 1 to 4 inclusive carbon atoms or hydrogen, and R'" is a divalent hydrocarbon radical of from 2 to 6 inclusive carbon atoms, and (B) from 5 to 50 parts by weight of at least one substantially water insoluble aliphatically unsaturated organic monomer which is compatible with said (A) cured by maintaining the composition under free radical polymerization conditions for a sufficient amount of time to obtain said polymerization product, said polymerization product being capable of absorbing at least 3% by weight of water based upon the total weight of said polymerization product before exposure to water, and (b) contacting the membrane with a reservoir of the bioactive agent.

Claim 2

A method of controlling the delivery of a bioactive agent to a substrate, comprising the steps of: (a) contacting the substrate with a membrane formed from a water absorbing, hydrophilic silicone organic elastomer comprising a polymerization product formed from a composition consisting essentially of (A) from 50 to 95 parts by weight of at least one block copolymer of the formula ##STR14## wherein Z is CH 2 ═CR"COOR'"NHCO--, ##STR15## Q is a divalent radical obtained by removing the NCO radicals from a diisocyanate selected from the group consisting of aliphatic, cycloaliphatic and aromatic diisocyanates, T is a divalent radical selected from the group consisting of --NR"-- and --O-- wherein said T is attached to a carbon atom on --C c H 2c -- which is at least the third carbon atom away from the silicon atom to which the --C c H 2c -- radical is attached, a is an integer of from 4 to 49, inclusive, b is an integer of from 0 to 15, inclusive, c is an integer having a value of 3 or 4, d is an integer of from 0 to 25, inclusive, e is an integer of from 5 to 50 inclusive, d+e is no greater than 50 and e is greater than or equal to d, f is 0 or 1, f' is 0 or 1, f+f'+b is at least 2, R is a monovalent hydrocarbon or halohydrocarbon radical of from 1 to 6 inclusive carbon atoms which is free of aliphatic unsaturation, R' is a methyl or a phenyl radical, R" is an alkyl radical of from 1 to 4 inclusive carbon atoms or hydrogen, and R'" is a divalent hydrocarbon radical of from 2 to 6 inclusive carbon atoms, and (B) from 5 to 50 parts by weight of at least one substantially water insoluble aliphatically unsaturated organic monomer which is compatible with said (A) cured by maintaining the composition under free radical polymerization conditions for a sufficient amount of time to obtain said polymerization product, said polymerization product being capable of absorbing at least 3% by weight of water based upon the total weight of said polymerization product before exposure to water, and (b) contacting the membrane with a reservoir of the bioactive agent.