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US4849511A Expired / Lapsed US ⏱️ 0.0 years remaining

Technetium chelates to be used for determining the renal function

Assignee: Mallinckrodt Inc
•
Filing: 1987-05-26
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Granted: 1989-07-18
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Expires: 2007-05-26
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Abstract

Abstract The invention relates to a technetium chelate of the general formula <CHEM> wherein X is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an aminosulphonyl group or a carboxymethylaminocarbonyl group, Tc represents technetium-99m, R1 is a hydrogen atom or an alkyl group having 1 or 2 carbon atoms, and R2, R3, R4, and R5 are dual or different and represent hydrogen atoms or branched or non-branched alkyl groups having 1-4 can atoms, which alkyl groups are optionally substituted with an amino group, a hydroxy group, a mercapto group, a halogen atom, a carboxy group or an aminocarbonyl group, with the proviso that R3, R4 and R5 do not all three of them represent hydrogen atoms; as well as water-soluble salts of these compounds. The invention also relates to a tripeptide compound to be used for preparing said chelate and to a kit oomprising a composition of said tripeptide compound.

Inventors

  • 👤 Alfons M. Verbruggen

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 05:15
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0827; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; C07F; C07F13/00; C07F13/005; A61K2123/00

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 146 words
A compound of the general formula ##STR8## wherein X is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an aminosulphonyl group or a carboxymethylaminocarbonyl group, Tc represents technetium-99m, R 1 is a hydrogen atom or an alkyl group having 1 or 2 carbon atoms, and R 2 , R 3 , R 4 and R 5 are equal or different and represent hydrogen atoms or branched or non-branched alkyl groups having 1-4 carbon atoms, which alkyl groups are optionally substituted with an amino group, a hydroxy group, a mercapto group, a halogen atom, a carboxy group or an aminocarbonyl group, with the proviso that R 3 , R 4 and R 5 do not all represent hydrogen atoms; as well as water-soluble salts of these compounds.
Claim 2
Dependent Claim 146 words
A compound of the general formula ##STR8## wherein X is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an aminosulphonyl group or a carboxymethylaminocarbonyl group, Tc represents technetium-99m, R 1 is a hydrogen atom or an alkyl group having 1 or 2 carbon atoms, and R 2 , R 3 , R 4 and R 5 are equal or different and represent hydrogen atoms or branched or non-branched alkyl groups having 1-4 carbon atoms, which alkyl groups are optionally substituted with an amino group, a hydroxy group, a mercapto group, a halogen atom, a carboxy group or an aminocarbonyl group, with the proviso that R 3 , R 4 and R 5 do not all represent hydrogen atoms; as well as water-soluble salts of these compounds.
Claim 3
Dependent Claim 101 words
A compound as claimed in claim 1, of the general formula I, wherein X is a sulphur atom, Z is a carboxy group or an alkoxycarbonyl group having 1-4 carbon atoms, Tc is technetium-99m, R 1 and R 2 represent hydrogen atoms, and R 3 , R 4 and R 5 are equal or different and represent hydrogen atoms, methyl groups, ethyl groups, isopropyl groups, aminomethyl groups, hydroxymethyl groups, mercaptomethyl groups or halomethyl groups, with the proviso that R 3 , R 4 and R 5 do not all represent hydrogen atoms; as well as a water-soluble salt of this compound.
Claim 4
Dependent Claim 82 words
A compound as claimed in claim 1, of the general formula I, wherein X, Z, Tc, R 1 and R 2 have the meanings given in claim 2, and R 3 , R 4 and R 5 are equal or different and represent hydrogen atoms, a methyl groups or hydroxymethyl groups, with the proviso that at least one of the symbols R 3 , R 4 and R 5 represents a methyl group; as well as a water-soluble salt of this compound.
Claim 5
Dependent Claim 56 words
A compound as claimed in claim 1, of the general formula I, wherein X, Z, Tc, R 1 and R 2 have the meanings given in claim 2, R 3 is a methyl group or a hydroxymethyl group, and R 4 and R 5 are hydrogen atoms; as well as a water-soluble salt of this compound.

References Cited (Backward Citations)

EP0173424A1 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-07-17 1993-01-16 1993-07-18 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-07-17 1997-01-16 1997-07-18 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-07-17 2001-01-16 2001-07-18 $7700.00 Window Closed / Lapsed

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