Skin treatment composition and method

Claim 2

A skin treatment composition which inhibits generation of or deactivates the free radicals in the skin which free radicals may form upon exposure of the skin to ultraviolet radiation or air pollutants, in the form of an ointment, cream, lotion, or liquid comprising water, at least one humectant, at least one thickener, at least one preservative, from about 0.01 to about 5% by weight of the composition of at least one free radical inhibitor or deactivator which is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-ethoxy-1, 2-dihyro-2,2,4-trimethylquinoline or mixtures thereof, and a stabilizer for said 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid which is monoethanolamine sulfite or sodium bisulfite, wherein said stabilizer is present in an amount within the range of from about 0.02 to about 0.5% by weight of said composition.

Claim 3

The composition as defined in claim 1 wherein the free radical inhibitor or deactivator of Claim 1 is present in an amount within the range of from about 0.1 to about 0.5% by weight of the composition.

Claim 4

The composition as defined in Claim 1 wherein the free radical inhibitor or deactivator is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid.

Claim 5

The composition as defined in claim 1 wherein the free radical inhibitor or deactivator is 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline.

Claim 6

The composition as defined in claim 1 further including a chelating agent which is disodium ethylene diamine tetraacetic acid, tetrasodium EDTA or citric acid.

Claim 7

The composition as defined in claim 1 in the form of a cream, lotion or ointment, wherein the thickener is a cross-linked acrylic acid polymer and including triethanolamine as a neutralizer for said thickener, or said thickener is xanthan gum, magnesium aluminum silicate, hydroxyethyl cellulose, carboxymethyl cellulose, cetyl alcohol or stearic acid.

Claim 8

The composition as defined in claim 1 wherein the humectant is propylene glycol, polyethylene glycol, glycerine, sorbitol or butylene glycol.

Claim 9

The composition as defined in claim 1 further including an emulsifier.

Claim 10

The composition as defined in claim 8 wherein the emulsifier is polyethylene glycol 20 sorbitan monolaurate, polyethylene glycol 5 soya sterol, sorbitan tristearate, sorbitan trioleate, glyceryl monopalmitate, diethanolamine cetyl phosphate, glyceryl monostearate, polyethylene glycol 100 stearate, polyethylene glycol 20 stearyl ether, polyethylene glycol ether of lauryl alcohol, polysorbate 80, lecithin or mixtures thereof.

Claim 11

The composition as defined in claim 1 further including an emollient.

Claim 12

The composition as defined in claim 10 wherein the emollient is dimethicone, stearoxydimethicone, diisopropyl dimerate or mineral oil.

Claim 13

The composition as defined in claim 1 wherein the preservative is benzyl alcohol, phenoxyethanol, butyl paraben, propylparaben, methyl paraben, imidazolidinyl urea, dimethyldimethoyl hydantoin, or a mixture thereof.

Claim 14

The composition as defined in claim 1 further including a solvent for the free radical inhibitor or deactivator.

Claim 15

The composition as defined in claim 1 wherein the solvent is propylene glycol, polyethylene glycol, ethanol and/or strong base or organic amine for 6-hydroxy-2,5,7,8 tetraethylchroman-2-carboxylic acid and vegetable oil or synthetic fatty acid esters for 6-ethoxy-1,2-dihydro-2,2,4-trimethyl quinoline.

Claim 16

The composition as defined in claim 1 wherein the free radical inhibitor or deactivator is present in an amount within the range of from about 0.1 to about 0.5% by weight and is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid and 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, the humectant is polyethylene glycol and propylene glycol, the emulsifier or thickener is polyethylene glycol 5 soya sterol, polyethylene glycol ether of lauryl alcohol, glyceryl monostearate, cetyl alcohol or stearic acid, and the preservative is benzyl alcohol, methyl paraben, propyl paraben or butylparaben.

Claim 17

The composition as defined in claim 15 further including disodium ethylenediamine tetracetic acid as a chelating agent, diisopropyl dimerate, dimethicone and stearoxy dimethicone as an emollient, and polyethylene glycol as a solvent for 6hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid.

Claim 18

The composition as defined in claim 1 further including at least one enzyme or modified enzyme.

Claim 19

The composition as defined in claim 1 further including at least one adjuvant oxygen deactivator.

Claim 20

A skin treatment composition which inhibits generation of or deactivates the free radicals in the skin which free radicals may form upon exposure of the skin to ultraviolet radiation or air pollutants, in the form of an ointment, cream, lotion, or liquid comprising water, at least one humectant, at least one thickener, at least one preservative, at least one chelating agent which is disodium ethylene diamine tetraacetic acid, ethylene diamine tetraacetic acid, tetrasodium ethylene diamine tetraacetic acid or citric acid, from about 0.01 to about 5% by weight of the composition of at least one free radical inhibitor or deactivator which is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-ethoxy-1,2-dihyro-2,2,4-trimethylquinoline or mixtures thereof, and a stabilizer for said 6-hydroxy-2,5,7,8-tetramethylchroman2-carboxylic acid which is monoethanolamine sulfite or sodium bisulfite, wherein said stabilizer is present in an amount within the range of from about 0.02 to about 0.5% by weight of said composition.

Claim 21

A skin treatment composition which inhibits generation of or deactivates the free radicals in the skin which free radicals may form upon exposure of the skin to ultraviolet radiation or air pollutants, in the form of an ointment, cream, lotion, or liquid comprising water, at least one humectant, at least one thickener, at least one preservative, at least one chelating agent which is disodium ethylene diamine tetraacetic acid, ethylene diamine tetraacetic acid, tetrasodium ethylene diamine tetraacetic acid or citric acid, from about 0.01 to about 5% by weight of the composition of at least one free radical inhibitor or deactivator which is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-ethoxy-1,2-dihyro-2,2,4-trimethylquinoline or mixtures thereof, and a stabilizer for said 6-hydroxy-2,5,7,8-tetramethylchroman2-carboxylic acid which is monoethanolamine sulfite or sodium bisulfite, wherein said stabilizer is present in an amount within the range of from about 0.02 to about 0.5% by weight of said composition.

Claim 22

A skin treatment composition which inhibits generation of or deactivates the free radicals in the skin which free radicals may form upon exposure of the skin to ultraviolet radiation or air pollutants, in the form of an ointment, cream, lotion, or liquid comprising water, at least one humectant, at least one enzyme or modified enzyme, at least one thickener, at least one preservative, from about 0.01 to about 5% by weight of the composition of at least one free radical inhibitor or deactivator which is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-ethoxy-1,2-dihyro-2,2,4-trimethylquinoline or mixtures thereof, and a stabilizer for said 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid which is monoethanolamine sulfite or sodium bisulfite, wherein said stabilizer is present in an amount within the range of from about 0.02 to about 0.5% by weight of said composition.

Claim 23

A skin treatment composition which inhibits generation of or deactivates the free radicals in the skin which free radicals may form upon exposure of the skin to ultraviolet radiation or air pollutants, in the form of an ointment, cream, lotion, or liquid comprising water, at least one humectant, at least one enzyme or modified enzyme, at least one thickener, at least one preservative, from about 0.01 to about 5% by weight of the composition of at least one free radical inhibitor or deactivator which is 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 6-ethoxy-1,2-dihyro-2,2,4-trimethylquinoline or mixtures thereof, and a stabilizer for said 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid which is monoethanolamine sulfite or sodium bisulfite, wherein said stabilizer is present in an amount within the range of from about 0.02 to about 0.5% by weight of said composition.

Claim 24

The composition as defined in claim 20 wherein the enzyme is glycol modified superoxide dismutase or catalase.

Claim 25

A skin treatment composition comprising 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid in an amount from about 0.01 to about 5% by weight of the composition and a stabilizer therefore in an amount from about 0.02 to about 0.5% by weight of said composition, which stabilizer is monoethanolamine sulfite or sodium bisulfite, said acid being employed in a molar ratio to said stabilizer within the range of from about 10:1 to about 0.5:1.

Claim 26

A skin treatment composition comprising 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid in an amount from about 0.01 to about 5% by weight of the composition and a stabilizer therefore in an amount from about 0.02 to about 0.5% by weight of said composition, which stabilizer is monoethanolamine sulfite or sodium bisulfite, said acid being employed in a molar ratio to said stabilizer within the range of from about 10:1 to about 0.5:1.

Claim 27

The composition as defined in claim 22 further including water and an additional preservative.