US4840940A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for reducing the occurrence of distal anastomotic intimal hyperplasia using fractionated heparin
Assignee: Individual
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Filing: 1987-10-21
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Granted: 1989-06-20
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Expires: 2007-10-21
Abstract
Abstract A method is provided for reducing the occurrence of anastomotic intimal hyperplasia in grafts of artery, vein, biologic or synthetic conduits having end-to-side distal anastomosis. The method includes administering a regimen of fractionated heparin to the subject. Administration of the fractionated heparin can be either intravenously, intraperitoneally, subcutaneously or orally. Preferred dosage is 50-80 mg./kg. body weight per day.
Inventors
- 👤 Vikrom S. Sottiurai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:09
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; C; C07; C07H; C07H11/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
58 words
A method for reducing the occurrence of intimal hyperplasia in grafts of substitute veins and arteries having end-to-side distal anastomosis, the method including administering a region of fractionated heparin to a subject into which said graft has been implanted, wherein said fractionated heparin is selected from the class consisting of fractionated heparin having O-sulfated, N-desulfated and N-acetylated endings.
Claim 2
Independent Claim
58 words
A method for reducing the occurrence of intimal hyperplasia in grafts of substitute veins and arteries having end-to-side distal anastomosis, the method including administering a region of fractionated heparin to a subject into which said graft has been implanted, wherein said fractionated heparin is selected from the class consisting of fractionated heparin having O-sulfated, N-desulfated and N-acetylated endings.
Claim 3
Dependent Claim
12 words
A method of claim 1 wherein said fractionated heparin is administered orally.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said fractionated heparin is administered intravenously.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said fractionated heparin is administered intravenously.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said fractionated heparin is administered subcutaneously.
Claim 7
Dependent Claim
27 words
The method of claim 1 wherein said fractionated heparin is administered daily in an amount between about 50 and about 80 mg./kg. body weight of said subject.
Claim 8
Dependent Claim
15 words
The method of claim 6 wherein said fractionated heparin is administered in divided doses daily.
Claim 9
Dependent Claim
14 words
The method of claim 1 wherein said graft is an autograft, allograft or xenograpft.
Claim 10
Dependent Claim
11 words
The method of claim 1 wherein said graft is a synthetic.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-19 | 1992-12-19 | 1993-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-19 | 1996-12-19 | 1997-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-19 | 2000-12-19 | 2001-06-20 | $7700.00 | Window Closed / Lapsed |