US4837304A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibitor of ribonucleotide reductase
Assignee: Merck and Co Inc
•
Filing: 1987-05-22
•
Granted: 1989-06-06
•
Expires: 2007-05-22
Abstract
Abstract A series of oligopeptides each of which contains a D-amino acid has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.
Inventors
- 👤 Victor M. Garsky
- 👤 Robert A. Stein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 18:08
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K38/00; C12; C12N; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16622
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
19 words
A peptide having one of the following amino acid sequence: ##STR1## and the amides and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
19 words
A peptide having one of the following amino acid sequence: ##STR1## and the amides and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
13 words
A composition containing a peptide of claim 1 in a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim
48 words
A method of inhibiting a ribonucleotide reductase enzyme of herpes simplex virus in vitro comprising contacting the enzyme with a peptide of claim 1 for a time and under conditions sufficient to inhibit the ability of the enzyme to catalyze the reduction of ribonucleotide diphosphates to deoxy-ribonucleotide diphosphates.
Claim 5
Dependent Claim
47 words
A peptide, according to claim 1 having one of the following amino acid sequence: ______________________________________
A V V N dD L,
A V V dN D L,
A V dV N D L,
dA V V N D L or
dY V V N D L.
______________________________________
Claim 6
Dependent Claim
60 words
A peptide, according to claim 1 wherein the amino acid sequence is: ______________________________________
Y A G A V V dN D L,
Y A G dA V V N D L,
Y A dA A V V N D L,
Y dA G A V V N D L or
dY A G A V V N D L.
______________________________________
References Cited (Backward Citations)
GB2185024A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-05 | 1992-12-05 | 1993-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-05 | 1996-12-05 | 1997-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-05 | 2000-12-05 | 2001-06-06 | $7700.00 | Window Closed / Lapsed |