US4835477A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the determination of the hematocrit level of whole blood and apparatus for carrying out the process
Assignee: Fresenius SE and Co KGaA
•
Filing: 1987-08-14
•
Granted: 1989-05-30
•
Expires: 2007-08-14
Abstract
Abstract There is described a method and apparatus for the determination of hematocrit levels in which both the conductivity of whole blood and the conductivity of blood plasma are determined together. While a conductivity cell (18) is being used for the determination of the conductivity of whole blood, the conductivity of plasma is calculated in a computer (30) with the aid of ion selective electrodes (14, 16) from the sodium or potassium concentrations.
Inventors
- 👤 Hans-Dietrich Polaschegg
- 👤 Detlef Westphal
- 👤 Klaus Metzner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:19
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3669; A61M1/3607; A61M1/3609; G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/492
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
73 words
A process for the determination of the hematocrit level of whole blood including the steps of: measuring the conductivity of the whole blood measuring the concentration of sodium ions or chloride ions in the whole blood determining the conductivity of blood plasma from the concentration of sodium ions or chloride ions in the whole blood, and determining the hematocrit level from the conductivity of the whole blood and the conductivity of blood plasma.
Claim 2
Dependent Claim
73 words
A process for the determination of the hematocrit level of whole blood including the steps of: measuring the conductivity of the whole blood measuring the concentration of sodium ions or chloride ions in the whole blood determining the conductivity of blood plasma from the concentration of sodium ions or chloride ions in the whole blood, and determining the hematocrit level from the conductivity of the whole blood and the conductivity of blood plasma.
Claim 3
Dependent Claim
50 words
A process according to claim 1 in which the concentration of sodium ions in the whole blood is measured, the concentration of potassium ions in the whole blood is measured, and the conductivity of blood plasma is determined from the concentrations of sodium and potassium ions in the whole blood.
Claim 4
Dependent Claim
74 words
A process according to claim 2 in which the conductivity of blood plasma is calculated according to the linear equation LF.sub.p =(A×C.sub.Na)+(B×C.sub.K)+D in which LF P represents the conductivity of blood plasma, C Na represents the concentration of sodium ions in the whole blood, C K represents the concentration of potassium ions in the whole blood, and A, B and D are correlation constants which are determined from a known value of plasma conductivity.
Claim 5
Dependent Claim
42 words
A process according to claim 3 in which the constant K amounts to about 72 to 88, the constant A amounts to about 0.058 to 0.082, the constant B amounts to about 1.2×A and the constant D amounts to 0 to 2.
Claim 6
Dependent Claim
27 words
A process according to claim 4 in which the constant K is about 80, the constant A is about 0.07 and the constant D is about 1.
Claim 7
Dependent Claim
110 words
A process according to claim 2 in which use is made of a quadratic approximation corresponding to the equation Hkt=(P×N.sup.2)+(Q×N) in which Hkt represents the hematocrit level, P lies between 37 and 57, Q lies between 44 and 60, N=1-(LF VB /LF P ), LF VB represents the conductivity of whole blood, LF P represents the conductivity of blood plasma and equals (A×C Na )+(B×C K )+D where C Na represents the concentration of sodium ions in the whole blood, C K represents the concentration of potassium ions in the whole blood, and A, B and D are correlation constants which are determined from a known value of plasma conductivity.
Claim 8
Dependent Claim
19 words
A process according to claim 6 to which P amounts to about 47 and Q amounts to about 52.
Claim 9
Dependent Claim
20 words
A process according to claim 1 in which the determination of ion concentrations is carried out with ion selective electrodes.
Claim 10
Dependent Claim
143 words
Apparatus for the determination of the hematocrit level of whole blood comprising: a device for measuring the conductivity of the whole blood, a device for determining the conductivity of blood plasma incorporating a sodium ion selective electrode for measuring the concentration of sodium ions in the whole blood or a chloride ion selective electrode for measuring the concentration of chloride ions in the whole blood and computing means (32 to 40) for the determination of the conductivity of blood plasma in response to a signal from the sodium ion selective electrode or the chloride ion selective electrode, and a determining unit (44) for receiving values from the device for measuring the conductivity of the whole blood and from the computing means (32 to 40) and for determining the hematocrit level from the conductivity of the whole blood and the conductivity of blood plasma.
Claim 11
Dependent Claim
143 words
Apparatus for the determination of the hematocrit level of whole blood comprising: a device for measuring the conductivity of the whole blood, a device for determining the conductivity of blood plasma incorporating a sodium ion selective electrode for measuring the concentration of sodium ions in the whole blood or a chloride ion selective electrode for measuring the concentration of chloride ions in the whole blood and computing means (32 to 40) for the determination of the conductivity of blood plasma in response to a signal from the sodium ion selective electrode or the chloride ion selective electrode, and a determining unit (44) for receiving values from the device for measuring the conductivity of the whole blood and from the computing means (32 to 40) and for determining the hematocrit level from the conductivity of the whole blood and the conductivity of blood plasma.
Claim 12
Dependent Claim
44 words
Apparatus according to claim 9 in which the device for measuring the conductivity of the whole blood comprises a conductivity cell (18) and a calculating unit (42) for determining the conductivity of the whole blood from a signal obtained from the conductivity cell (18).
Claim 13
Dependent Claim
73 words
Apparatus according to claim 10 comprising a computer (30) incorporating the computing means (32 to 40), the calculating unit (42) and the determining unit (44) and in which the computing means (32 to 40) includes a summer (40) and both the summer (40) and the calculating unit (42) are connected to the determining unit (44) to supply signals respectively representative of the conductivity of blood plasma and the conductivity of the whole blood.
Claim 14
Dependent Claim
40 words
Apparatus according to claim 9 in which the device for determining the conductivity of blood plasma incorporates sodium ion selective and potassium ion selective electrodes, both of which are operable to supply signals to the computing means (32 to 40).
Claim 15
Dependent Claim
99 words
Apparatus according to claim 12 in which the computing means (32 to 40) comprises computing units (32 and 34) respectively for the determination of the sodium ion and potassium ion concentrations from signals from the sodium ion selective electrode (14) and the potassium ion selective electrode (16), coordinating units (36 and 38) with which the concentration values determined respectively in the computing units (32 and 34) are respectively multiplied with constants (A and B), and a summer (40) with which the values determined respectively in the coordinating units (36 and 38) are added together with a further constant (D).
Claim 16
Dependent Claim
52 words
Apparatus according to claim 12 in which the device for measuring the conductivity of the whole blood comprises a conductivity cell (18) and a conduit (20) for conveying the whole blood and a housing (12) which surrounds the ion selective electrodes (14 and 16), the conductivity cell (18) and the conduit (20).
References Cited (Backward Citations)
FR2308099A1
Cited
US4202747A
Cited
US4452682A
Cited
US4484135A
Cited
US4547735A
Cited
DE3416956A1
Cited
US4686479A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-29 | 1992-11-28 | 1993-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-29 | 1996-11-28 | 1997-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-29 | 2000-11-28 | 2001-05-30 | $7700.00 | Window Closed / Lapsed |