US4834964A
Expired / Lapsed
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Use of charged nitroxides as NMR image enhancing agents for CSF
Assignee: MRI Inc
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Filing: 1986-03-07
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Granted: 1989-05-30
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Expires: 2006-03-07
Abstract
Abstract Charged, stable, organic nitroxides, e.g., charged by a quaternary ammonium or a Bronsted acid group, are useful as NMR image enhancing agents for cerebrospinal fluid.
Inventors
- 👤 Gerald M. Rosen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:41
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/92; C07D211/94; C07D207/00; C07D207/46; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
82 words
A method of enhancing the image obtained by NMR scanning of a portion surrounding the spinal cord of the body of a vertebrate, which comprises injecting into the vertebrate's cerebrospinal fluid (CSF), a composition comprising a non-toxic injectable pharmacologically acceptable aqueous vehicle and an amount of a charged, stable organic nitroxide which is neurologically acceptable and non-toxic in the amount injected, effective to reduce the T. relaxation time of the CSF and scanning the spinal cord to obtain an enhanced NMR image.
Claim 2
Independent Claim
82 words
A method of enhancing the image obtained by NMR scanning of a portion surrounding the spinal cord of the body of a vertebrate, which comprises injecting into the vertebrate's cerebrospinal fluid (CSF), a composition comprising a non-toxic injectable pharmacologically acceptable aqueous vehicle and an amount of a charged, stable organic nitroxide which is neurologically acceptable and non-toxic in the amount injected, effective to reduce the T. relaxation time of the CSF and scanning the spinal cord to obtain an enhanced NMR image.
Claim 3
Dependent Claim
13 words
A method according to claim 1, wherein the vertebrate is a human being.
Claim 4
Dependent Claim
22 words
A method according to claim 2, wherein the portion of the body being scanned is a cross section of the spinal canal.
Claim 5
Dependent Claim
18 words
A method according to claim 2, wherein the amount of charged nitroxide injected is less than 0.5 millimole.
Claim 6
Dependent Claim
16 words
A method according to claim 1, wherein the nitroxide is charged by a quaternary ammonium group.
Claim 7
Dependent Claim
15 words
A method according to claim 5, wherein the quaternary ammonium group is a tri-lower-alkylammonium halide.
Claim 8
Dependent Claim
19 words
A method according to claim 1, wherein the nitroxide is charged by a carboxylic, sulfonic or phosphonic acid group.
Claim 9
Dependent Claim
114 words
A method according to claim 1, wherein the charged nitroxide is a heterocyclic nitroxyl compound of the formula ##STR3## wherein R 1 , R 2 , R 3 and R 4 each are alkyl of 1-4 carbon atoms; A is alkylene or alkenylene of 2-4 carbon atoms, --CH 2 --O--CH 2 --, or --CH 2 --S--CH 2 --; and R is --COO - M+ wherein M+ is ammonium, Na+ or K+ or R is --N + (Alk) 3 Hal - wherein Alk is alkyl of 1-8 carbon atoms or a corresponding alkyl group substituted by a free or esterified hydroxy group and Hal - is Cl - , Br - or I - .
Claim 10
Dependent Claim
46 words
A method according to claim 8, wherein R 1 , R 2 , R 3 and R 4 are CH 3 or C 2 H 5 and A is an --(CH 2 ) 2 -- or --(CH 2 ) 3 -- group bearing the R group.
Claim 11
Dependent Claim
16 words
A method according to claim 9, wherein R is --COO - M + as defined therein.
Claim 12
Dependent Claim
16 words
A method according to claim 9, wherein R is --N(Alk) 3 Hal - as defined therein.
Claim 13
Dependent Claim
15 words
A method according to claim 11, wherein the nitroxide is 4-(N,N-dimethyl-N-ethylamino)-2,2,6,6-tetramethylpiperidinoxyl chloride, bromide or iodide.
Claim 14
Dependent Claim
12 words
A method according to claim 11, wherein the nitroxide is 4-(N,N-dimethyl-N-ethylamino)-2,2,6,6-tetramethylpiperidinoxyl iodide.
Claim 15
Dependent Claim
16 words
A method according to claim 1, wherein the charged nitroxide is injected as a single dose.
Claim 16
Dependent Claim
151 words
A method according to claim 1, wherein the portion of the body being scanned is a cross section of the spinal canal, wherein the amount of charged nitroxide injected is less than 0.5 millimoles, wherein the charged nitrogen is administered as a single dose, and wherein the charged nitroxide is a heterocyclic nitroxyl compound of the formula ##STR4## wherein R 1 , R 2 , R 3 and R 4 each are alkyl of 1-4 carbon atoms; A is alkylene or alkenylene of 2-4 carbon atoms, --CH 2 --O--CH 2 --, or --CH 2 --S--CH 2 --; and R is --COOM+ wherein M+ is ammonium, Na+ or K+ or R is N + (Alk) 3 Hal - wherein Alk is alkyl of 1-8 carbon atoms or a corresponding alkyl group substituted by a free or esterified hydroxy group and Hal - is Cl - , Br - or I - .
Claim 17
Dependent Claim
15 words
A method according to claim 15, wherein the nitroxide is 4-(N,N-dimethyl-N-ethylamino)-2,2,6,6-tetramethylpiperidinoxyl chloride, bromide or iodide.
References Cited (Backward Citations)
EP0133674A1
Cited
US4656026A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-29 | 1992-11-28 | 1993-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-29 | 1996-11-28 | 1997-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-29 | 2000-11-28 | 2001-05-30 | $7700.00 | Window Closed / Lapsed |