US4833165A
Expired / Lapsed
US
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Method of inactivating HTLV-III virus in blood
Assignee: Pall Corp
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Filing: 1987-10-07
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Granted: 1989-05-23
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Expires: 2007-10-07
Abstract
Abstract HTLV-III virus in blood or blood components is inactivated by treatment with about 0.1-5% of phenol, formaldehyde, or mixtures thereof, at a temperature of about 2 DEG -40 DEG C. for at least about 5 minutes.
Inventors
- 👤 Allan L. Louderback
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:47
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K31/00; A61K31/11; A61K31/115; A61K35/00; A61K35/12; A61K35/14; A61K35/18; A61L; A61L2/00; A61L2/16; A61L2/18; A61L2103/00; A61L2103/05; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/14011; C12N2740/14061; C12N2740/14063; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
132 words
A method of inactivating HTLV-III virus in blood collected for administration to a human being in need of said blood which comprising the steps of: separating red blood cells from whole blood contaminated by said virus washing said red blood cells in a saline solution, resuspending said red blood cells in a saline solution; treating said red blood cells with an effective amount of from about 0.1% to about 5% by weight of said resuspended red blood cell and saline solution of a chemical agent selected from the group consisting of phenol, formaldehyde and mixtures thereof at a temperature of from about 2° C. to about 40° C. for at least about 5 minutes; and thoroughly washing the residual chemical agent from the thus treated red blood cells with a saline solution.
Claim 2
Independent Claim
132 words
A method of inactivating HTLV-III virus in blood collected for administration to a human being in need of said blood which comprising the steps of: separating red blood cells from whole blood contaminated by said virus washing said red blood cells in a saline solution, resuspending said red blood cells in a saline solution; treating said red blood cells with an effective amount of from about 0.1% to about 5% by weight of said resuspended red blood cell and saline solution of a chemical agent selected from the group consisting of phenol, formaldehyde and mixtures thereof at a temperature of from about 2° C. to about 40° C. for at least about 5 minutes; and thoroughly washing the residual chemical agent from the thus treated red blood cells with a saline solution.
Claim 3
Dependent Claim
35 words
A method of claim 1 in which the red blood cells are resuspended in a saline solution in proportions of about one volume of cells to about 5 to 30 parts by volume of saline.
Claim 4
Dependent Claim
23 words
The method of claim 1 in which the treatment time with the chemical agent ranges from about 30 minutes to about 60 minutes.
Claim 5
Dependent Claim
12 words
The method of claim 1 in which the chemical agent is formaldehyde.
Claim 6
Dependent Claim
12 words
The method of claim 1 in which the chemical agent is phenol.
References Cited (Backward Citations)
US3973913A
Cited
US4675159A
Cited
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