US4832038A
Expired / Lapsed
US
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Apparatus for monitoring cardiovascular regulation using heart rate power spectral analysis
Assignee: University of Illinois System
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Filing: 1987-01-20
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Granted: 1989-05-23
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Expires: 2007-01-20
Abstract
Abstract Apparatus for heart rate fluctuation power spectrum analysis obtains an electrocardiogram signal from an electrocardiograph machine and a respiratory rate signal from an electroplethysmograph machine. These signals are processed by a data acquisition system to provide output suitable for heart rate fluctuation power spectrum analysis by a mini-micro-computer. Data manipulation includes correction of artifacts by substituting an appropriate heartbeat interval for detected heartbeat intervals for which the variance exceeds a preselected range of slewing rates. Trending of data and overlapping data analysis increase the analytical capabilities of the apparatus. Methods of treatment for conditions manifested by abnormalities in a heart rate fluctuation power spectrum involve applying treatments when spectral abnormalities are observed. Specific abnormalities indicating the need for treatment include: a level below about 0.1 (beats/min.)2 in the power spectrum of heart rate fluctuations at a frequency between about 0.04 and about 0.10 Hz; a marked increase to above about 10 (beats/min.)2 in heart rate fluctuations at a frequency between 0.04 and about 0.10 Hz; and a ratio of the area under a heart rate fluctuation power spectrum of a peak at a frequency between about 0.04 and about 0.10 Hz to the area under a peak in the respiratory heart rate fluctuation power spectrum centered at the mean respiratory rate (as measured by the apparatus) at about 0.1 Hz as having a value less than 2.0 for longer than or equal to about one hour or as having an absolute value greater than about 50.
Inventors
- 👤 Makoto R. Arai
- 👤 David Gordon
- 👤 Laura E. McAlpine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:30
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/02; A61B5/024; A61B5/02405; A61B5/48; A61B5/4884; A61B5/72; A61B5/7235; A61B5/7253; A61B5/7257
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
129 words
An apparatus for correcting artifacts in a series of heartbeats comprising: means for collecting a series of heartbeat samples; means, coupled to said means for collecting, for selecting an appropriate interval between heartbeats; means, coupled to said means for selecting, for identifying a mean variance among the intervals between heartbeat samples; means, coupled to said means for identifying, for establishing an acceptable range of slewing rates as a function of the means variance; means, coupled to said means for selecting, for particularizing the absolute value of the slewing rate of a heartbeat sample relative to the mean interval; and means, coupled to said means for particularizing, for substituting the appropriate interval between heartbeats for all heartbeat interval samples having an absolute value outside the range of acceptable slewing rates.
Claim 2
Independent Claim
129 words
An apparatus for correcting artifacts in a series of heartbeats comprising: means for collecting a series of heartbeat samples; means, coupled to said means for collecting, for selecting an appropriate interval between heartbeats; means, coupled to said means for selecting, for identifying a mean variance among the intervals between heartbeat samples; means, coupled to said means for identifying, for establishing an acceptable range of slewing rates as a function of the means variance; means, coupled to said means for selecting, for particularizing the absolute value of the slewing rate of a heartbeat sample relative to the mean interval; and means, coupled to said means for particularizing, for substituting the appropriate interval between heartbeats for all heartbeat interval samples having an absolute value outside the range of acceptable slewing rates.
Claim 3
Dependent Claim
34 words
The apparatus as recited in claim 1 wherein said means for selecting an appropriate interval comprises means for dividing intervals having a length equal to a multiple of the appropriate interval by the multiple.
Claim 4
Dependent Claim
25 words
The apparatus as recited in claim 1 wherein said means for selecting an appropriate interval comprises means for discarding interval shorter than a predetermined length.
Claim 5
Dependent Claim
63 words
The apparatus as recited in claim 1 wherein said means for selecting an appropriate interval comprises means for determining a mean interval and means for substituting a mean interval for intervals having preceded by a preselected number of intervals having an absolute value outside the range of acceptable slewing rates and having an absolute value outside of the range of acceptable slewing rates.
Claim 6
Independent Claim
85 words
A method for correcting artifacts in a series of heartbeats comprising the steps of: collecting a series of heartbeat samples; selecting an appropriate interval between heartbeats; identifying variances in the intervals between heartbeats; establishing an acceptable range of slewing rates as a function of a mean variance; particularizing the absolute value of the slewing rate of a heartbeat sample relative to the mean interval; and substituting the selected interval for all heartbeat interval samples having an absolute value outside the range of acceptable slewing rates.
Claim 7
Independent Claim
85 words
A method for correcting artifacts in a series of heartbeats comprising the steps of: collecting a series of heartbeat samples; selecting an appropriate interval between heartbeats; identifying variances in the intervals between heartbeats; establishing an acceptable range of slewing rates as a function of a mean variance; particularizing the absolute value of the slewing rate of a heartbeat sample relative to the mean interval; and substituting the selected interval for all heartbeat interval samples having an absolute value outside the range of acceptable slewing rates.
Claim 8
Dependent Claim
31 words
The method as recited in claim 5 wherein said selecting step comprises the step of dividing intervals having a length equal to a multiple of the appropriate interval by the multiple.
Claim 9
Dependent Claim
58 words
The method as recited in claim 5 wherein said selecting step comprises the steps of determining a mean interval and substituting a mean interval for intervals having preceded by a preselected number of intervals having an absolute value outside the range of acceptable slewing rates and having an absolute value outside of the range of acceptable slewing rates.
Claim 10
Dependent Claim
23 words
The method as recited in claim 5 wherein said selecting step comprises the step of discarding an interval shorter than a predetermined length.
Claim 11
Dependent Claim
69 words
Apparatus for calibrating a heart rate power spectrum monitor comprising: means for supplying a signal simulating a heart rate; means for generating a signal simulating a respiratory frequency fluctuation in heart rate; means for providing a signal simulating a low frequency fluctuation in heart rate; and means for applying signals from said means for supplying, said means for generating and said means for providing to a power spectrum monitor.
Claim 12
Dependent Claim
69 words
Apparatus for calibrating a heart rate power spectrum monitor comprising: means for supplying a signal simulating a heart rate; means for generating a signal simulating a respiratory frequency fluctuation in heart rate; means for providing a signal simulating a low frequency fluctuation in heart rate; and means for applying signals from said means for supplying, said means for generating and said means for providing to a power spectrum monitor.
Claim 13
Dependent Claim
67 words
Apparatus for heart rate fluctuation power spectral analysis comprising: means for providing an electrocardiogram signal; means for supplying an electroplethysmogram signal; means, coupled to said means for providing and to said means for supplying, for obtaining a heart rate fluctuation power spectrum from an electrocardiogram signal and an electroplethysmogram signal; and relative means, coupled to said means for obtaining, for displaying a heart rate fluctuation power spectrum.
Claim 14
Dependent Claim
67 words
Apparatus for heart rate fluctuation power spectral analysis comprising: means for providing an electrocardiogram signal; means for supplying an electroplethysmogram signal; means, coupled to said means for providing and to said means for supplying, for obtaining a heart rate fluctuation power spectrum from an electrocardiogram signal and an electroplethysmogram signal; and relative means, coupled to said means for obtaining, for displaying a heart rate fluctuation power spectrum.
Claim 15
Dependent Claim
121 words
Apparatus for trending heart rate fluctuation power spectral data comprising: means for providing an electrocardiogram signal; means for supplying an electroplethysmogram signal; means, coupled to said means for providing and to said means for supplying, for obtaining a heart rate fluctuation power spectrum from an electrocardiogram signal and from an electroplethysmogram signal; and means, coupled to said means for obtaining, for storing heart rate fluctuation power spectral data; addressable means, coupled to said means for storing, for transmitting stored heart rate fluctuation power spectral data; means, coupled to said addressable means for transmitting, for converting heart rate fluctuation power spectral data into graphic form; and real time means, coupled to said means for converting, for displaying heart rate fluctuation power spectra.
Claim 16
Dependent Claim
121 words
Apparatus for trending heart rate fluctuation power spectral data comprising: means for providing an electrocardiogram signal; means for supplying an electroplethysmogram signal; means, coupled to said means for providing and to said means for supplying, for obtaining a heart rate fluctuation power spectrum from an electrocardiogram signal and from an electroplethysmogram signal; and means, coupled to said means for obtaining, for storing heart rate fluctuation power spectral data; addressable means, coupled to said means for storing, for transmitting stored heart rate fluctuation power spectral data; means, coupled to said addressable means for transmitting, for converting heart rate fluctuation power spectral data into graphic form; and real time means, coupled to said means for converting, for displaying heart rate fluctuation power spectra.
Claim 17
Dependent Claim
26 words
The apparatus according to claim 11 further comprising: means, coupled between said means for obtaining and said means for storing, for segmenting data into overlapping samples.
Claim 18
Independent Claim
89 words
A method for treatment of a condition related to malfunctions of the cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; identifying a level below about 0.1 (beats/min.) 2 in the power spectrum of heart rate fluctuations at a frequency between about 0.04 and about 0.10 Hz as indicative of cardiovascular stress; and applying a procedure to treat the condition and thereby to increase the level of heart rate fluctuations between about 0.04 and about 0.10 Hz.
Claim 19
Independent Claim
89 words
A method for treatment of a condition related to malfunctions of the cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; identifying a level below about 0.1 (beats/min.) 2 in the power spectrum of heart rate fluctuations at a frequency between about 0.04 and about 0.10 Hz as indicative of cardiovascular stress; and applying a procedure to treat the condition and thereby to increase the level of heart rate fluctuations between about 0.04 and about 0.10 Hz.
Claim 20
Independent Claim
87 words
A method for treatment of a condition related to malfunctions of the cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; and identifying a marked increase to above about 10 (beats/min.) 2 in heart rate fluctuations at a frequency between about 0.04 to about 0.10 Hz as indicative of cardiovascular instability; and applying a procedure to treat the condition and thereby to decrease the level of heart rate fluctuations between about 0.04 and 0.10 Hz.
Claim 21
Independent Claim
87 words
A method for treatment of a condition related to malfunctions of the cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; and identifying a marked increase to above about 10 (beats/min.) 2 in heart rate fluctuations at a frequency between about 0.04 to about 0.10 Hz as indicative of cardiovascular instability; and applying a procedure to treat the condition and thereby to decrease the level of heart rate fluctuations between about 0.04 and 0.10 Hz.
Claim 22
Independent Claim
106 words
A method for treatment of a condition related to cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; and identifying a ratio of the area under a heart rate fluctuation power spectrum of a peak at a frequency between about 0.04 and about 0.1 Hz to the area under a peak in the heart rate fluctuation power spectrum centered at the mean respiratory rate about 0.1 Hz as having an absolute value less than 2.0 as indicative of cardiac instability; and applying a procedure to treat the condition and thereby to increase the ratio.
Claim 23
Independent Claim
106 words
A method for treatment of a condition related to cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; and identifying a ratio of the area under a heart rate fluctuation power spectrum of a peak at a frequency between about 0.04 and about 0.1 Hz to the area under a peak in the heart rate fluctuation power spectrum centered at the mean respiratory rate about 0.1 Hz as having an absolute value less than 2.0 as indicative of cardiac instability; and applying a procedure to treat the condition and thereby to increase the ratio.
Claim 24
Independent Claim
108 words
A method for treatment of a condition related to cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; and identifying a ratio of the area under a heart rate fluctuation power spectrum of a peak at a frequency between about 0.04 and about 0.1 Hz to the area under a peak in the heart rate fluctuation power spectrum centered at the mean respiratory rate about 0.1 Hz as having an absolute value greater than or about 50 as indicative of cardiovascular stress; and applying a procedure to treat the condition and thereby to increase the ratio.
Claim 25
Independent Claim
108 words
A method for treatment of a condition related to cardiovascular control system in a patient comprising the steps of: monitoring a power spectrum of heart rate fluctuations in the patient; and identifying a ratio of the area under a heart rate fluctuation power spectrum of a peak at a frequency between about 0.04 and about 0.1 Hz to the area under a peak in the heart rate fluctuation power spectrum centered at the mean respiratory rate about 0.1 Hz as having an absolute value greater than or about 50 as indicative of cardiovascular stress; and applying a procedure to treat the condition and thereby to increase the ratio.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-22 | 1992-11-21 | 1993-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-22 | 1996-11-21 | 1997-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-22 | 2000-11-21 | 2001-05-23 | $7700.00 | Window Closed / Lapsed |