US4830720A
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Method for purifying a dipeptide ester
Assignee: Tosoh Corp
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Filing: 1988-10-26
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Granted: 1989-05-16
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Expires: 2008-10-26
Abstract
Abstract A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by ion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing organic acids to the central compartment defined by anion and cation exchange membranes or by anion exchange membranes and an aqueous electrolyte solution to the cathode and anode compartments, and electrically removing the organic acids from the central compartment to the anode compartment through the anion exchange membrane.
Inventors
- 👤 Tsuneo Harada
- 👤 Ken-ichi Fukuda
- 👤 Hiroshi Shimizu
- 👤 Akira Tokuda
- 👤 Kiyotaka Oyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 15:05
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06104; C07K5/06113; C07K5/06121; C07K5/0613; C07K1/00; C07K1/14; C07K1/24
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
86 words
A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by ion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing organic acids to the central compartment defined by anion and cation exchange membranes or by anion exchange membranes and an aqueous electrolyte solution to the cathode and anode compartments, and electrically removing the organic acids from the central compartment to the anode compartment through the anion exchange membrane.
Claim 2
Independent Claim
86 words
A method for purifying a dipeptide ester by electrolysis in an electrolytic cell comprising an anode compartment, a cathode compartment and a central compartment partitioned by ion exchange membranes, which comprises supplying an aqueous dipeptide ester solution containing organic acids to the central compartment defined by anion and cation exchange membranes or by anion exchange membranes and an aqueous electrolyte solution to the cathode and anode compartments, and electrically removing the organic acids from the central compartment to the anode compartment through the anion exchange membrane.
Claim 3
Dependent Claim
14 words
The method according to claim 1, wherein the dipeptide ester is α-L-aspartyl-L-phenylalanine methyl ester.
Claim 4
Dependent Claim
14 words
The method according to claim 1, wherein the organic acids are 1,3-benzyl-6-carboxymethyl-2,5-diketopiperazine and α-L-aspartyl-L-phenylalanine.
Claim 5
Dependent Claim
28 words
The method according to claim 1, wherein the electrolytic cell is partitioned into at least three compartments by anion and cation exchnge membranes or by anion exchange membranes.
Claim 6
Dependent Claim
21 words
The method according to claim 1, wherein the temperature for electrolysis is within a range of from 10° to 80° C.
Claim 7
Dependent Claim
20 words
The method according to claim 1, wherein the pH of the aqueous dipeptide ester solution is from 3.5 to 7.0.
References Cited (Backward Citations)
US2788319A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-15 | 1992-11-14 | 1993-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-15 | 1996-11-14 | 1997-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-15 | 2000-11-14 | 2001-05-16 | $7700.00 | Window Closed / Lapsed |