US4830716A
Expired / Lapsed
US
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Preparation of pharmaceutical grade amino acid chelates
Assignee: Albion Laboratories Inc
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Filing: 1986-07-03
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Granted: 1989-05-16
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Expires: 2006-07-03
Abstract
Abstract Pharmaceutical grade amino acid chelates, free of interfering anions, are made by reacting an amino acid ligand with a metal member selected from the group consisting of elemental metals, metal oxides, metal hydroxides and metal carbonates in an aqueous environment wherein the ligand to metal mole ratio is at least 2:1 and recovering the amino acid chelate from said aqueous environment by means of spray or drum drying. The reaction may be carried out in the presence of non-interfering anions such as anions from citric acid, ascorbic acid, acetic acid, carbonic acid and ammonium and alkali metal salts thereof.
Inventors
- 👤 Harvey H. Ashmead
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 16:08
CPC Classifications
C; C07; C07C; C07C51/00; C07C51/41
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
102 words
A method for the preparation of pharmaceutical grade amino acid chelates, substantially free of interfering anions, which comprises reacting an anion free ligand selected from the group consisting of naturally occurring amino acids, or dipeptides, tripeptides or quadrapeptides thereof, in an aqueous environment, with a metal member selected from the group consisting of elemental metals, metal oxides, metal hydroxides and metal carbonates, wherein the metal is member selected from the group consisting of calcium, copper, iron, magnesium, manganese and zinc, and wherein the mole ratio of ligand to metal is at least 2:1 and recovering the amino acid chelate thus formed therefrom.
Claim 2
Independent Claim
102 words
A method for the preparation of pharmaceutical grade amino acid chelates, substantially free of interfering anions, which comprises reacting an anion free ligand selected from the group consisting of naturally occurring amino acids, or dipeptides, tripeptides or quadrapeptides thereof, in an aqueous environment, with a metal member selected from the group consisting of elemental metals, metal oxides, metal hydroxides and metal carbonates, wherein the metal is member selected from the group consisting of calcium, copper, iron, magnesium, manganese and zinc, and wherein the mole ratio of ligand to metal is at least 2:1 and recovering the amino acid chelate thus formed therefrom.
Claim 3
Dependent Claim
35 words
A method according to claim 1 wherein the molecular weight of the amino acid chelate formed does not exceed 1500 and wherein the mole ratio of ligand to metal is between about 2:1 to 4:1.
Claim 4
Dependent Claim
20 words
A method according to claim 2 wherein an electrical potential is applied to the aqueous environment to expedite the reaction.
Claim 5
Dependent Claim
19 words
A method according to claim 2 wherein an electrolyte is added to the aqueous environment to expedite the reaction.
Claim 6
Dependent Claim
33 words
A method according to claim 4 wherein the electrolyte is a member selected from the group consisting of citric acid, ascorbic acid, acetic acid, carbonic acid and ammonium and alkali metal salts thereof.
Claim 7
Dependent Claim
26 words
A method according to claim 3 wherein the potential is a direct electrical current and wherein the elemental metal forms the anode of an electrolytic cell.
Claim 8
Dependent Claim
33 words
A method according to claim 2 wherein the metal member is a metal oxide selected from the group consisting of calcium oxide, copper oxide, iron oxide, magnesium oxide, manganese oxide and zinc oxide.
Claim 9
Dependent Claim
26 words
A method according to claim 7 wherein the metal oxide is a member selected from the group consisting of calcium oxide, magnesium oxide and zinc oxide.
Claim 10
Dependent Claim
24 words
A method according to claim 7 wherein said aqueous environment consists of sufficient water to bring said metal oxide at least partially into solution.
Claim 11
Dependent Claim
39 words
A method according to claim 9 wherein said reaction is carried out in the presence of an agent selected from the group consisting of citric acid, ascorbic acid, acetic acid, carbonic acid and ammonium and alkali metal salts thereof.
Claim 12
Dependent Claim
25 words
A method according to claim 9 wherein said amino acid chelate is recovered from said aqueous environment by means of spray drying or drum drying.
Claim 13
Dependent Claim
33 words
A method according to claim 2 wherein the metal member is a metal hydroxide selected from the group consisting of calcium hydroxide, copper hydroxide, iron hydroxide, magnesium hydroxide, manganese hydroxide and zinc hydroxide.
Claim 14
Dependent Claim
24 words
A method according to claim 12 wherein said aqueous environment consists of sufficient water to bring said metal hydroxide at least partially into solution.
Claim 15
Dependent Claim
39 words
A method according to claim 13 wherein said reaction is carried out in the presence of an agent selected from the group consisting of citric acid, ascorbic acid, acetic acid, carbonic acid and ammonium and alkali metal salts thereof.
Claim 16
Dependent Claim
25 words
A method according to claim 13 wherein said amino acid chelate is recovered from said aqueous environment by means of spray drying or drum drying.
Claim 17
Dependent Claim
29 words
A method according to claim 12 wherein said aqueous environment consists of only sufficient water to form a moist paste of said metal hydroxide and amino acid chelate ligand.
Claim 18
Dependent Claim
40 words
A method according to claim 16 wherein said moist paste is allowed to stand under ambient conditions for a determined period of time after which it is diluted with water, filtered and the filtrate is spray dried or drum dried.
Claim 19
Dependent Claim
33 words
A method according to claim 2 wherein the metal member is a metal carbonate selected from the group consisting of calcium carbonate, copper carbonate, iron carbonate, magnesium carbonate, manganese carbonate and zinc carbonate.
Claim 20
Dependent Claim
24 words
A method according to claim 18, wherein said aqueous environment consists of sufficient water to bring said metal carbonate at least partially into solution.
Claim 21
Dependent Claim
39 words
A method according to claim 19 wherein said reaction is carried out in the presence of an agent selected from the group consisting of citric acid, ascorbic acid, acetic acid, carbonic acid and ammonium and alkali metal salts thereof.
Claim 22
Dependent Claim
27 words
A method according to claim 20 wherein said agent is a member selected from the group consisting of carbonic acid an ammonium and alkali metal salts thereof.
Claim 23
Dependent Claim
13 words
A method according to claim 21 wherein said metal carbonate is copper carbonate.
Claim 24
Dependent Claim
25 words
A method according to claim 19 wherein said amino acid chelate is recovered from said aqueous environment by means of spray drying or drum drying.
Claim 25
Dependent Claim
29 words
A method according to claim 18 wherein said aqueous environment consists of only sufficient water to form a moist paste of said metal carbonate and amino acid chelate ligand.
Claim 26
Dependent Claim
40 words
A method according to claim 24 wherein said moist paste is allowed to stand under ambient conditions for a determined period of time after which it is diluted with water, filtered and the filtrate is spray dried or drum dried.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-15 | 1992-11-14 | 1993-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-15 | 1996-11-14 | 1997-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-15 | 2000-11-14 | 2001-05-16 | $7700.00 | Window Closed / Lapsed |