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US4827491A Expired / Lapsed US ⏱️ 0.0 years remaining

Radiosurgical collimator knife

Assignee: New York University
•
Filing: 1987-01-15
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Granted: 1989-05-02
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Expires: 2007-01-15
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Abstract

Abstract Apparatus for treatment by radiation of an intracranial portion disposed at a predetermined region, comprises a linear accelerator for supplying a source of energetic electrons, and a collimator disposed adjacent the predetermined region for supplying an X-ray source of radiation to the predetermined region. The collimator includes a plurality of channels oriented toward the predetermined region. Each channel has a target which produces the X-ray radiation when the respective target is selectively exposed to the energetic electrons. The collimator also has a cover layer of radiation attentuation material having a low atomic or Z number and that extends over the outer surface of the collimator but leaves unexposed the plurality of channels. Preferably, the cover layer has a thickness at least equal to the range of the energetic electrons. A method of treating an intracranial portion with the apparatus of the present invention is also disclosed.

Inventors

  • 👤 Robert J. Barish

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 20:56
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1077; A61N5/1084

Claims Analysis

Total Claims: 48
Claim 1
Independent Claim 195 words
Apparatus for therapeutic treatment by radiation of a portion of a body disposed at a predetermined region, comprising: 1. first means for supplying a first source of high energy particle radiation; 2. second means disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said second means including at least one bore generally oriented toward the predetermined region and said bore having respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation; and 3. cover means formed of radiation attenuation means and disposed on said second means adjacent said at least one bore so as to attenuate a portion of said first source of high energy particle radiation to which said respective target is not exposed.
Claim 2
Dependent Claim 195 words
Apparatus for therapeutic treatment by radiation of a portion of a body disposed at a predetermined region, comprising: 1. first means for supplying a first source of high energy particle radiation; 2. second means disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said second means including at least one bore generally oriented toward the predetermined region and said bore having respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation; and 3. cover means formed of radiation attenuation means and disposed on said second means adjacent said at least one bore so as to attenuate a portion of said first source of high energy particle radiation to which said respective target is not exposed.
Claim 3
Dependent Claim 200 words
Apparatus for therapeutic treatment by radiation of a portion of a body disposed at a predetermined region, comprising: 1. first means for supplying a first source of high energy particle radiation; 2. second means disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said second means including a plurality of bores generally oriented toward the predetermined region and each bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, each said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation; and 3. cover means formed of radiation attenuation means and disposed on said second means adjacent said first ends of said plurality of bores so as to attenuate a portion of said first source of high energy particle radiation to which said radiation targets are not exposed.
Claim 4
Dependent Claim 200 words
Apparatus for therapeutic treatment by radiation of a portion of a body disposed at a predetermined region, comprising: 1. first means for supplying a first source of high energy particle radiation; 2. second means disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said second means including a plurality of bores generally oriented toward the predetermined region and each bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, each said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation; and 3. cover means formed of radiation attenuation means and disposed on said second means adjacent said first ends of said plurality of bores so as to attenuate a portion of said first source of high energy particle radiation to which said radiation targets are not exposed.
Claim 5
Dependent Claim 22 words
The apparatus according to claim 2 wherein each said respective radiation target is disposed adjacent said first end of each said bore.
Claim 6
Dependent Claim 240 words
Apparatus for treatment by radiation of a portion of a body disposed at a predetermined region, comprising: a. first means for supplying a first source of high energy particle radiation; b. second means disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, said second means including a plurality of bores generally oriented toward the predetermined region and each bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, each said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation; and c. cover means formed of radiation attenuation means and disposed on said second means adjacent said first ends of said plurality of bores so as to attenuate a portion of said first source of high energy particle radiation to which said radiation targets are not exposed; wherein each said radiation target is disposed adjacent said first end of said respective bore and wherein said second means is a radiation collimator formed of radiation attenuation material such that said secondary radiation is generally limited in cross-sectional area at said predetermined region to about the cross-sectional area of said second end of said respective bore.
Claim 7
Dependent Claim 240 words
Apparatus for treatment by radiation of a portion of a body disposed at a predetermined region, comprising: a. first means for supplying a first source of high energy particle radiation; b. second means disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, said second means including a plurality of bores generally oriented toward the predetermined region and each bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, each said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation; and c. cover means formed of radiation attenuation means and disposed on said second means adjacent said first ends of said plurality of bores so as to attenuate a portion of said first source of high energy particle radiation to which said radiation targets are not exposed; wherein each said radiation target is disposed adjacent said first end of said respective bore and wherein said second means is a radiation collimator formed of radiation attenuation material such that said secondary radiation is generally limited in cross-sectional area at said predetermined region to about the cross-sectional area of said second end of said respective bore.
Claim 8
Dependent Claim 45 words
The apparatus according to claim 4 wherein said cover means extends over said second means so as to completely cover the surface of said second means facing said first radiation source means and to leave said respective radiation targets exposed to said first radiation source.
Claim 9
Dependent Claim 22 words
The apparatus according to claim 5 wherein said bores are oriented so as to generally intersect at a predetermined common focal point.
Claim 10
Dependent Claim 57 words
The apparatus according to claim 5 wherein said second means includes a first plurality of bores and a second plurality of bores, said first plurality of bores being oriented so as to intersect at a first predetermined focal point and said second plurality of bores being oriented so as to intersect at a second predetermined focal point.
Claim 11
Dependent Claim 23 words
The apparatus according to claim 5 wherein said bores are oriented so as to provide a radiation cross-section of predetermined configuration and dimension.
Claim 12
Dependent Claim 30 words
The apparatus according to claim 5 wherein said second end of each of said bores is dimensioned so that said predetermined region is smaller in cross-section than about four millimeters.
Claim 13
Dependent Claim 18 words
The apparatus according to claim 5 wherein each said bore is generally uniform in cross-section along its length.
Claim 14
Dependent Claim 14 words
The apparatus according to claim 5 wherein said bores are of different cross-sectional dimensions.
Claim 15
Dependent Claim 176 words
Apparatus for therapeutic treatment by radiation of an intracranial portion disposed at a predetermined region, comprising: 1. first means for supplying a source of energetic electrons; 2. second means disposed adjacent the predetermined region for supplying an X-ray source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said second means including a plurality of bores generally oriented toward the predetermined region and each bore having a respective target which produces the X-ray radiation when said respective target is selectively exposed to said energetic electrons, each said bore having a first end being closest to said first means and a second end being closest to said predetermined region when said respective target is selectively exposed to said energetic electrons; and 3. cover means formed of radiation attenuation means and disposed on said second means adjacent said first ends of said plurality of bores so as to attenuate a portion of said source of energetic electrons to which said radiation targets are not exposed.
Claim 16
Dependent Claim 176 words
Apparatus for therapeutic treatment by radiation of an intracranial portion disposed at a predetermined region, comprising: 1. first means for supplying a source of energetic electrons; 2. second means disposed adjacent the predetermined region for supplying an X-ray source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said second means including a plurality of bores generally oriented toward the predetermined region and each bore having a respective target which produces the X-ray radiation when said respective target is selectively exposed to said energetic electrons, each said bore having a first end being closest to said first means and a second end being closest to said predetermined region when said respective target is selectively exposed to said energetic electrons; and 3. cover means formed of radiation attenuation means and disposed on said second means adjacent said first ends of said plurality of bores so as to attenuate a portion of said source of energetic electrons to which said radiation targets are not exposed.
Claim 17
Dependent Claim 22 words
The apparatus according to claim 12 wherein each said respective target is disposed adjacent said first end of each said respective bore.
Claim 18
Dependent Claim 47 words
The apparatus according to claim 13 wherein said second means includes a collimator formed of radiation attenuation material such that said X-ray radiation is generally limited in cross-sectional area at said predetermined region to about the cross-sectional area of said second end of each said respective bore.
Claim 19
Dependent Claim 42 words
The apparatus according to claim 14 wherein said cover means extends over said second means so as to completely cover the surface of said second means facing said first means and to leave said respective radiation targets exposed to said first means.
Claim 20
Dependent Claim 48 words
The apparatus according to claim 15 wherein said cover means is formed of radiation attenuation means having a low atomic number so as to absorb electrons from said first means and so as to generally prevent X-ray radiation from being produced at locations other than said respective target.
Claim 21
Dependent Claim 24 words
The apparatus according to claim 16 wherein said cover means is of a thickness at least equal to the range of the energetic electrons.
Claim 22
Dependent Claim 15 words
The apparatus according to claim 17 wherein said cover means is of a uniform thickness.
Claim 23
Dependent Claim 14 words
The apparatus according to claim 15 wherein said first means is a linear accelerator.
Claim 24
Dependent Claim 22 words
The apparatus according to claim 15 wherein said bores are oriented so as to generally intersect at a predetermined common focal point.
Claim 25
Dependent Claim 57 words
The apparatus according to claim 15 wherein said second means includes a first plurality of bores and a second plurality of bores, said first plurality of bores being oriented so as to intersect at a first predetermined focal points and said second plurality of bores being oriented so as to intersect at a second predetermined focal point.
Claim 26
Dependent Claim 23 words
The apparatus according to claim 15 wherein said bores are oriented so as to provide a radiation cross-section of predetermined configuration and dimension.
Claim 27
Dependent Claim 30 words
The apparatus according to claim 15 wherein said second end of each of said bores is dimensioned so that said predetermined region is smaller in cross-section than about four millimeters.
Claim 28
Dependent Claim 18 words
The apparatus according to claim 15 wherein each said bore is generally uniform in cross-section along its length.
Claim 29
Dependent Claim 14 words
The apparatus according to claim 15 wherein said bores are of different cross-sectional dimensions.
Claim 30
Dependent Claim 18 words
The apparatus according to claim 15 further comprising means for locating the intracranial portion at the predetermined region.
Claim 31
Dependent Claim 14 words
The apparatus according to claim 26 wherein said locating means is a stereotactic frame.
Claim 32
Dependent Claim 31 words
The apparatus according to claim 15 further comprising computer means coupled to and controlling said first means for supplying a predetermined sequence and duration of selective irradiation of said respective targets.
Claim 33
Dependent Claim 22 words
The apparatus according to claim 15 further comprising means for supporting and moving the intracranial portion within and about the predetermined region.
Claim 34
Dependent Claim 33 words
The apparatus according to claim 29 further comprising computer means coupled to and controlling said support and movement means for supplying a predetermined sequence and duration of selective irradiation of said respective targets.
Claim 35
Dependent Claim 31 words
The apparatus according to claim 30 wherein said first means comprises a plurality of linear accelerators oriented at a plurality of said respective targets for simultaneous irradiation of said respective targets.
Claim 36
Dependent Claim 29 words
The apparatus according to claim 15 wherein said first means comprises a plurality of linear accelerators oriented at a respective plurality of targets for simultaneous irradiation of said targets.
Claim 37
Dependent Claim 199 words
Apparatus for therapeutic treatment by radiation of a portion of a body disposed at a predetermined region, comprising: 1. means for supplying a source of energetic electrons; 2. means disposed adjacent the predetermined region for supplying an X-ray source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said X-ray means including a bore generally oriented toward the predetermined region and configured so as to approximate the configuration of the body portion to be treated, said bore having a target which produces the X-ray radiation when said target is selectively exposed to said energetic electrons, said channel having a first end being closest to said electron source means and a second end being closest to said predetermined region when said target is selectively exposed to said energetic electrons; and 3. cover means formed of radiation attenuation means having a relatively low atomic number and disposed on said second means adjacent said bore so as to attenuate a portion of said first source of radiation to which said target is not exposed, said cover means having a thickness at least equal the range of the energetic electrons.
Claim 38
Dependent Claim 199 words
Apparatus for therapeutic treatment by radiation of a portion of a body disposed at a predetermined region, comprising: 1. means for supplying a source of energetic electrons; 2. means disposed adjacent the predetermined region for supplying an X-ray source of radiation to the predetermined region, wherein said secondary source produces radiation at an energy level appropriate for therapeutic treatment by radiation, said X-ray means including a bore generally oriented toward the predetermined region and configured so as to approximate the configuration of the body portion to be treated, said bore having a target which produces the X-ray radiation when said target is selectively exposed to said energetic electrons, said channel having a first end being closest to said electron source means and a second end being closest to said predetermined region when said target is selectively exposed to said energetic electrons; and 3. cover means formed of radiation attenuation means having a relatively low atomic number and disposed on said second means adjacent said bore so as to attenuate a portion of said first source of radiation to which said target is not exposed, said cover means having a thickness at least equal the range of the energetic electrons.
Claim 39
Independent Claim 179 words
A method for treating a portion of a body with radiation, comprising: 1. positioning the portion of the body to be treated at a predetermined region; 2. supplying a first source of high energy particle radiation; and 3. disposing a collimator adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, said collimator including at least one bore generally oriented toward the predetermined region and said bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, said channel having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said first source of high energy particle radiation; said collimator further including cover means formed of radiation attenuation means and disposed on said collimator adjacent said at least one channel so as to attenuate a portion of said first source of high energy particle radiation to which said respective target is not exposed.
Claim 40
Independent Claim 179 words
A method for treating a portion of a body with radiation, comprising: 1. positioning the portion of the body to be treated at a predetermined region; 2. supplying a first source of high energy particle radiation; and 3. disposing a collimator adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, said collimator including at least one bore generally oriented toward the predetermined region and said bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, said channel having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said first source of high energy particle radiation; said collimator further including cover means formed of radiation attenuation means and disposed on said collimator adjacent said at least one channel so as to attenuate a portion of said first source of high energy particle radiation to which said respective target is not exposed.
Claim 41
Independent Claim 12 words
A method for treating a portion of a body with radiation, comprising:
Claim 42
Independent Claim 12 words
A method for treating a portion of a body with radiation, comprising:
Claim 43
Dependent Claim 178 words
positioning the portion of the body to be treated at a predetermined region; 2. supplying a first source of high energy particle radiation; and 3. disposing a collimator disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, said collimator including a plurality of bores generally oriented toward the predetermined region and each bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, each said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation, said collimator further including cover means formed of radiation attenuation means and disposed on said collimator adjacent said first ends of said plurality of channels so as to attenuate a portion of said first source of high energy particle radiation to which said radiation targets are not exposed.
Claim 44
Dependent Claim 178 words
positioning the portion of the body to be treated at a predetermined region; 2. supplying a first source of high energy particle radiation; and 3. disposing a collimator disposed adjacent the predetermined region for supplying a secondary source of radiation to the predetermined region, said collimator including a plurality of bores generally oriented toward the predetermined region and each bore having a respective radiation target which produces the secondary radiation when said respective target is selectively exposed to said first source of high energy particle radiation, each said bore having a first end being closest to said first source of high energy particle radiation and a second end being closest to said predetermined region when said respective target is selectively exposed to said first source of high energy particle radiation, said collimator further including cover means formed of radiation attenuation means and disposed on said collimator adjacent said first ends of said plurality of channels so as to attenuate a portion of said first source of high energy particle radiation to which said radiation targets are not exposed.
Claim 45
Dependent Claim 21 words
The method according to claim 35 wherein said first source of high energy particle radiation is a source of energetic electrons.
Claim 46
Dependent Claim 15 words
The method according to claim 36 wherein said secondary source of radiation is X-ray radiation.
Claim 47
Dependent Claim 19 words
The method according to claim 35 wherein said positioning of the body portion is performed with a stereotactic frame.
Claim 48
Dependent Claim 40 words
The method according to claim 35 further comprising coupling and controlling said first source of high energy particle source of radiation by computer means, said computer means supplying a predetermined sequence and duration of selective irradiation of said respective targets.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1992-05-01 1992-10-31 1993-05-02 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1996-05-01 1996-10-31 1997-05-02 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2000-05-01 2000-10-31 2001-05-02 $7700.00 Window Closed / Lapsed

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