US4826984A
Expired / Lapsed
US
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Heteroarotinoid compounds as anticancer agents
Assignee: Oklahoma State University
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Filing: 1987-01-27
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Granted: 1989-05-02
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Expires: 2007-01-27
Abstract
Abstract Novel heteroarotinoid compositions characterized by the formulae: ##STR1## where R is H, CH 3 or C 2 H 5 and X is S, S O, O, NCH 3 , Si(CH 3 ) 2 , N + (H)CH 3 [Cl - ], N + (H)CH 3 [Br - ] or N + (alkyl) CH 3 [Cl - or Br - ) where alkyl is CH 3 , C 2 H 5 , CH 2 ═CHCH 2 or C 6 H 5 CH 2 . Such compositions exhibit activity as anticancer agents.
Inventors
- 👤 Kenneth D. Berlin
- 👤 Elizabeth M. Holt
- 👤 Warren T. Ford
- 👤 Mark D. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:59
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D333/00; C07D333/50; C07D333/52; C07D333/54; C07D335/00; C07D335/04; C07D335/06; C07D409/00; C07D409/02; C07D409/12
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
101 words
A compound selected from the group characterized by the formulae: ##STR24## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR25## ##STR26## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR27## ##STR28## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR29## ##STR30## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR31## ##STR32## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR33## and ##STR34## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR35##
Claim 2
Dependent Claim
101 words
A compound selected from the group characterized by the formulae: ##STR24## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR25## ##STR26## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR27## ##STR28## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR29## ##STR30## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR31## ##STR32## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR33## and ##STR34## where R is H, OH, OCH 3 , OC 2 H 5 or ##STR35##
Claim 3
Dependent Claim
36 words
A compound selected from the group characterized by the formula: ##STR36## wherein X is selected from O, S, and S→O, and wherein R is selected from H, CH3 - , and C 2 H 5 .
Claim 4
Dependent Claim
36 words
A compound selected from the group characterized by the formula: ##STR36## wherein X is selected from O, S, and S→O, and wherein R is selected from H, CH3 - , and C 2 H 5 .
Claim 5
Dependent Claim
24 words
A compound according to claim 2 consisting essentially of the trans isomer wherein X is S and R is C 2 H 5 .
Claim 6
Dependent Claim
24 words
A compound according to claim 2 consisting essentially of the trans isomer wherein X is O and R is C 2 H 5 .
Claim 7
Dependent Claim
24 words
A compound according to claim 2 consisting essentially of the trans isomer wherein X is S→O and R is C 2 H 5 .
Claim 8
Dependent Claim
20 words
A compound according to claim 2 consisting essentially of the trans isomer wherein X is O and R is H.
Claim 9
Dependent Claim
36 words
A compound selected from the group characterized by the formulas: ##STR37## wherein X is selected from O, S, and S→O, and wherein R is selected from H, CH 3 , and C 2 H 5 .
Claim 10
Dependent Claim
36 words
A compound selected from the group characterized by the formulas: ##STR37## wherein X is selected from O, S, and S→O, and wherein R is selected from H, CH 3 , and C 2 H 5 .
Claim 11
Dependent Claim
25 words
A compound according to claim 7 consisting essentially of the trans isomer wherein X is S and R is OH - or OCH 3 .
Claim 12
Dependent Claim
24 words
A compound according to claim 7 consisting essentially of the trans isomer wherein X is S→O and R is H or OCH 3 .
Claim 13
Dependent Claim
22 words
A compound according to claim 7 consisting essentially of the trans isomer wherein X is O and R is OCH 3 .
Claim 14
Dependent Claim
20 words
A compound according to claim 7 consisting essentially of the trans isomer wherein X is S and R is H.
Claim 15
Dependent Claim
22 words
A compound according to claim 7 consisting essentially of the trans isomer wherein X is S and R is OCH 3 .
Claim 16
Dependent Claim
20 words
A compound according to claim 7 consisting essentially of the trans isomer wherein X is O and R is H.
References Cited (Backward Citations)
GB2119801A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-05-01 | 1992-10-31 | 1993-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-01 | 1996-10-31 | 1997-05-02 | $3760.00 | Window Closed / Lapsed |
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