US4824669A
Expired / Lapsed
US
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Formulations of coenzyme Q10 for intravenous use
Assignee: The University of Texas System
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Filing: 1987-03-27
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Granted: 1989-04-25
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Expires: 2007-03-27
Abstract
Abstract The present invention comprises a stable and non-toxic coenzyme Q10 formulation suitable for intravenous administration to an animal to produce clinically effective blood levels of coenzyme Q10. Clinically effective blood levels of coenzyme Q10 are generally agreed to be between about 2 ug/ml and about 4 ug/ml. The formulation consists essentially of a clinically accepted fatty emulsion having an oil phase and coenzyme Q10 dissolved in the oil phase. The formulation preferably contains coenzyme Q10 at a level between about 7.5 ug/ml and about 30 ug/ml. The clinically accepted fatty emulsion comprises at least one vegetable oil, preferably corn oil, peanut oil, safflower oil, olive oil or soybean oil.
Inventors
- 👤 Karl Folkers
- 👤 Kazumasa Muratsu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/12; A61K47/00; A61K47/44
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
66 words
A stable and non-toxic coenzyme Q 10 formulation suitable for intravenous administration to an animal to produce clinically effective blood levels of coenzyme Q 10 , the formulation consisting essentially of a clinically accepted fatty emulsion having an oil phase and coenzyme Q 10 dissolved in the oil phase, the formulation containing coenzyme Q 10 at a level between about 7.5 μg/ml and about 30 μg/ml.
Claim 2
Dependent Claim
66 words
A stable and non-toxic coenzyme Q 10 formulation suitable for intravenous administration to an animal to produce clinically effective blood levels of coenzyme Q 10 , the formulation consisting essentially of a clinically accepted fatty emulsion having an oil phase and coenzyme Q 10 dissolved in the oil phase, the formulation containing coenzyme Q 10 at a level between about 7.5 μg/ml and about 30 μg/ml.
Claim 3
Dependent Claim
15 words
The formulation of claim 1 wherein the fatty emulsion comprises at least one vegetable oil.
Claim 4
Dependent Claim
25 words
The formulation of claim 2 wherein the vegetable oil is at least one of corn oil, peanut oil, safflower oil, olive oil or soybean oil.
Claim 5
Dependent Claim
18 words
The formulation of claim 1 wherein the clinically accepted fatty emulsion comprises from 10% to 20% vegetable oil.
Claim 6
Dependent Claim
24 words
The formulation of claim 1 wherein the clinically accepted blood levels of coenzyme Q 10 are between about 2 μg/ml and about 4 μg/ml.
Claim 7
Dependent Claim
18 words
The formulation of claim 1 wherein the formulation is defined further as being essentially free of exogenous detergent.
Claim 8
Independent Claim
71 words
A method for preparing a stable and non-toxic coenzyme Q 10 formulation suitable for intravenous administration to an animal to produce clinically effective blood levels of coenzyme Q 10 , the method comprising thoroughly mixing a clinically accepted fatty emulsion having an oil phase with an amount of coenzyme Q 10 sufficient to result in a formulation having a coenzyme Q 10 concentration between about 7.5 μg/ml and about 30 μg/ml.
Claim 9
Independent Claim
71 words
A method for preparing a stable and non-toxic coenzyme Q 10 formulation suitable for intravenous administration to an animal to produce clinically effective blood levels of coenzyme Q 10 , the method comprising thoroughly mixing a clinically accepted fatty emulsion having an oil phase with an amount of coenzyme Q 10 sufficient to result in a formulation having a coenzyme Q 10 concentration between about 7.5 μg/ml and about 30 μg/ml.
Claim 10
Dependent Claim
15 words
The method of claim 7 wherein the fatty emulsion comprises at least one vegetable oil.
Claim 11
Dependent Claim
25 words
The method of claim 8 wherein the vegetable oil is at least one of corn oil, peanut oil, safflower oil, olive oil or soybean oil.
Claim 12
Dependent Claim
18 words
The method of claim 8 wherein the clinically accepted fatty emulsion comprises from 10% to 20% vegetable oil.
Claim 13
Dependent Claim
31 words
The method of claim 7 defined further wherein the coenzyme Q 10 is initially in a vegetable oil solution and the solution is thoroughly mixed with the clinically accepted fatty emulsion.
Claim 14
Dependent Claim
18 words
The method of claim 7 wherein the thorough mixing comprises sonication or repeated passage through a small orifice.
Claim 15
Dependent Claim
24 words
The method of claim 7 wherein the clinically effective blood levels of coenzyme Q 10 are between about 2 μg/ml and about 4 μg/ml.
Claim 16
Dependent Claim
18 words
The method of claim 7 wherein the formulation is defined further as being essentially free of exogenous detergent.
Claim 17
Independent Claim
72 words
A method for raising blood levels of coenzyme Q 10 to clinically effective levels in an animal, the method comprising: obtaining a stable and non-toxic formulation comprising a clinically accepted fatty emulsion and coenzyme Q 10 at a concentration between about 7.5 μg/ml and about 30 μg/ml; and intravenously administering said formulation to the animal to achieve blood levels of coenzyme Q 10 of between about 2 μg/ml and about 4 μg/ml.
Claim 18
Independent Claim
72 words
A method for raising blood levels of coenzyme Q 10 to clinically effective levels in an animal, the method comprising: obtaining a stable and non-toxic formulation comprising a clinically accepted fatty emulsion and coenzyme Q 10 at a concentration between about 7.5 μg/ml and about 30 μg/ml; and intravenously administering said formulation to the animal to achieve blood levels of coenzyme Q 10 of between about 2 μg/ml and about 4 μg/ml.
Claim 19
Dependent Claim
15 words
The method of claim 15 wherein the fatty emulsion comprises at least one vegetable oil.
Claim 20
Dependent Claim
25 words
The method of claim 16 wherein the vegetable oil is at least one of corn oil, peanut oil, safflower oil, olive oil or soybean oil.
Claim 21
Dependent Claim
18 words
The method of claim 15 wherein the clinically accepted fatty emulsion comprises from 10% to 20% vegetable oil.
Claim 22
Dependent Claim
18 words
The method of claim 15 wherein the formulation is defined further as being essentially free of exogenous detergent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-24 | 1992-10-24 | 1993-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-24 | 1996-10-24 | 1997-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-24 | 2000-10-24 | 2001-04-25 | $7700.00 | Window Closed / Lapsed |