US4822887A
Expired / Lapsed
US
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Preparation of difluoropyridine compounds
Assignee: Dow Chemical Co
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Filing: 1988-02-29
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Granted: 1989-04-18
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Expires: 2008-02-29
Abstract
Abstract Alpha, beta-difluoropyridine compounds are prepared by contacting a 2,3-dihalopyridine compound or suitable precursor thereof with an effective amount of KF or CsF in a polar aprotic solvent (diluent) at an elevated temperature under substantially anhydrous conditions with removal of the difluoropyridine products essentially as they are formed. The starting material may optionally be added as the reaction proceeds to minimize decomposition. The reaction is also optionally conducted in the presence of an acid scavenger and/or a crown ether or other phase-transfer catalyst.
Inventors
- 👤 John C. Little
- 👤 Charles A. Wilson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:48
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/61
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
99 words
A method of preparing a product compound having the formula ##STR3## wherein X is Br or Cl, which comprises contacting a starting compound having the formula ##STR4## wherein each X is individually Br or Cl and Y is F, Cl or Br with an effective amount of KF in a polar aprotic diluent at an effective temperature of from 50° C. to the boiling point of the diluent, optionally in the presence of a phase-transfer catalyst, removing the product compound by distillation essentially as it is formed, and, optionally, adding additional starting compound as the product compound is removed.
Claim 2
Independent Claim
99 words
A method of preparing a product compound having the formula ##STR3## wherein X is Br or Cl, which comprises contacting a starting compound having the formula ##STR4## wherein each X is individually Br or Cl and Y is F, Cl or Br with an effective amount of KF in a polar aprotic diluent at an effective temperature of from 50° C. to the boiling point of the diluent, optionally in the presence of a phase-transfer catalyst, removing the product compound by distillation essentially as it is formed, and, optionally, adding additional starting compound as the product compound is removed.
Claim 3
Dependent Claim
15 words
Method of claim 1 wherein the 2,3-dihalopyridine compound is 2,3,5-trichloropyridine and the product is 2,3-difluoro-5-chloropyridine.
Claim 4
Dependent Claim
15 words
Methood of claim 1 wherein the 2,3-dihalopyridine compound is 2,3,5-tribromopyridine and the product is 2,3-difluoro-5-bromopyridine.
Claim 5
Dependent Claim
30 words
Method of claim 1 wherein the fluoride salt is KF and the reaction is carried out in the presence of (a) a phase-transfer catalyst and optionally (b) an acid scavenger.
Claim 6
Dependent Claim
12 words
Method of claim 1 wherein the diluent is dimethylsulfoxide, sulfolane or N-methylpyrrolidinone.
Claim 7
Dependent Claim
25 words
Method of claim 1 wherein the salt is KF and the reaction temperature is from 175° C. up to the boiling point of the diluent.
Claim 8
Dependent Claim
19 words
Method of claim 1 wherein the reaction is carried out at a pressure from 50 to 300 mm Hg.
Claim 9
Dependent Claim
18 words
Method of claim 4 wherein the phase-transfer catalyst is a quaternary ammonium halide, a crown ether, or tris(3,6-dioxaheptyl)amine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |