US4822872A
Expired / Lapsed
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Method of purifying factor VIII
Assignee: Tanabe Pharma Corp
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Filing: 1987-05-15
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Granted: 1989-04-18
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Expires: 2007-05-15
Abstract
Abstract A method for purifying factor VIII complex comprising: (A) absorbing an impure extract containing factor VIII complex on a water-insoluble carrier, and (B) recovering factor VIII complex in the unadsorbed fractions, wherein said water-insoluble carrier contains as a ligand a group represented by the formula (I) or (II): -(CH2)n-NH2(I) or -(CH2)n-CHO(II) wherein n is an integer of from 3 to 10.
Inventors
- 👤 Syojyu Kameyama
- 👤 Hideo Nishimaki
- 👤 Yoshiro Iga
- 👤 Tadakazu Suyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:30
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61K; A61K38/00; H; H01; H01R; H01R13/00; H01R13/46; H01R13/52; H01R13/5205
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
65 words
A method for purifying factor VIII complex comprising: (A) adsorbing an impure extract containing factor VIII complex on a water-insoluble carrier, and (B) recovering factor VIII complex in the unadsorbed fractions, wherein said water-insoluble carrier contains as a ligand a group represented by the formula (I) or (II): (CH.sub.2).sub.n --NH.sub.2 (I) or (CH.sub.2).sub.n --CHO (II) wherein n is an integer of from 3 to 10.
Claim 2
Independent Claim
65 words
A method for purifying factor VIII complex comprising: (A) adsorbing an impure extract containing factor VIII complex on a water-insoluble carrier, and (B) recovering factor VIII complex in the unadsorbed fractions, wherein said water-insoluble carrier contains as a ligand a group represented by the formula (I) or (II): (CH.sub.2).sub.n --NH.sub.2 (I) or (CH.sub.2).sub.n --CHO (II) wherein n is an integer of from 3 to 10.
Claim 3
Dependent Claim
36 words
The method as claimed in claim 1, wherein said water-insoluble carrier contains a ligand represented by the group consisting of an aminobutyl group, an aminohexyl group, an aminooctyl group, an aminodecyl group and a formylbutyl group.
Claim 4
Dependent Claim
23 words
The method as claimed in claim 1, wherein said water-insoluble carrier is selected from the group consisting of water-insoluble polysaccharide and polyvinyl-based gel.
Claim 5
Dependent Claim
20 words
The method as claimed in claim 3, wherein said polysaccharide is selected from the group consisting of agarose and cellulose.
Claim 6
Dependent Claim
16 words
The method as claimed in claim 1, wherein said impure extract is a cryoprecipitate of plasma.
References Cited (Backward Citations)
US4381239A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |